jj astream

PowerPoint Presentation: 

PRESENTED BY Jadhav J. R . M. Pharm second year Department of Pharmaceutics Amrutvahini college of pharmacy sangamner . 1 SURFACTANT

Contents: 

Contents Basic surfactant chemistry. Terminology. Surfactant classification. General properties. Applications. 2

Definition: 

Definition A substance which has both water-loving and oil-loving structural components in the same molecule. 3

PowerPoint Presentation: 

Oil and water don’t mix! 4

Structure of the surfactant : 

Structure of the surfactant Tail group Head group (Hydrophobic (Hydrophilic or Lipophilic) or lipophobic ) Example:- - Alkyl phenol -Ethylene oxide - Fatty alcohol -Sulfate. 5

How Micelle form?: 

How Micelle form? 6

PowerPoint Presentation: 

Colloidal size clusters in solution called as micelle. Micelle size and shape depends on surfactant concentration and salt concentration. 7 Important Action:-

PROPERTIES:-: 

PROPERTIES:- WETTING AGENT:- 8 Properties WETTING AGENT No surfactant added Surfactant added Liquid remains as drop on the Reduction in surface Surface. liquid allows spreading.

Classification: 

Classification A ) Ionic Anionic Ammonium lauryl sulfate. Perflurooctanoate (PFOA) Sodium dodecyl sulfate (SDS) Cationic Benzethonium chloride (BZT) Cetyl trimethylammonium bromide (CTAB) Benzalkonium chloride (BAC) 9

PowerPoint Presentation: 

Zwitterionic ( amphoteric ) Dodecyl betaine Coco ampho glycinate B) Nonionic Alkyl poly(ethylene oxide) Alkylphenol poly(ethylene oxide) Alkyl polyglucosides:- Octyl glucoside Decyl maltoside 10

PowerPoint Presentation: 

Fatty alcohol Cetyl alcohol Oleyl alcohol Polysorbates Tween 20 Tween 60 Tween 80 Span 20 Span 60 Span 80 11

HLB: 

HLB Is an arbitrary scale. Proposed by Griffin. Spans( Sorbitan ester) Lipophilic -(1.8-8.6) Tweens ( polyoxyetylene derivatives of spans)-Hydrophilic(9.6-16.7) 12

HLB RANGES AND ITS APPLICATION: 

HLB RANGES AND ITS APPLICATION HLB RANGE APPLICATION 1-3 Antifoaming agent 3-8 W/O Emulsifying agent. 7-9 Wetting agent 8-16 O/W Emulsifying agent 13-16 Detergent 16-19 Solubilizing agent. 13

Methods of Estimation: 

Methods of Estimation Method 1 : HLB = ∑(hydrophilic group number) - ∑(lipophilic group number) + 7 Method 2: HLB = E +P 5 E=% by wt. of ethylene oxide chains. P=% by wt. of polyhydric alcohol groups. 14

PowerPoint Presentation: 

Method 3: HLB = 20 (1 - S ) A S = Saponification no. of the ester. A= Acid no. of the fatty acid. 15

Poloxamer: 

Poloxamer Pleuronics Composed of several hydrophobic chain of polyoxypropylene [poly(propyleneoxide)] flanked by two hydrophilic chains of polyoxethylene [poly(ethylene oxide)] “poloxamer” these co-polymers are commonly named with the letter “P”(for poloxamer) followed by three digits. (e.g., P407 ) 16

PowerPoint Presentation: 

For the Pleuronic tradename , coding of these copolymers starts with a letter to define its physical form at room temperature L = liquid, P = paste, F = flake (solid) e.g., L6 1 P 1 8 1 =L6 1 17

Poloxamer 407: 

Poloxamer 407 Hydrophilic non-ionic surfactant “Poloxamer 407” is a triblock co-polymer consisting of a central hydrophobic block of polypropylene glycol flanked by two hydrophilic blocks of polyethylene glycol. 18

Applications: 

Applications Improve Wetting surface. Reduced surface tension. Natural intestinal detergent. Provide cleaning. Antibacterial activity. 19

Summary: 

Summary Surfactants are substances with both water-loving and oil-loving structural components. Surfactants are divided into four classes depending on charge. Micelles solubilizes oil and are responsible for detergency. 20

REFERENCES : 

REFERENCES Encyclopedia’s “Pharmaceutical Technology”, Vol-2,P.2646. Disperse System”“, Remington ; The science and practice of pharmacy Vol. I ,21 st Edition , Lippincott Williams and Wilkins,1669. Herbert A, Lieberman, Leon , Lachman and Joseph B, Schwartz “Pharmaceutical disperse system “ Vol -2 , 2 nd edition ,New York,100 . Alfred martin , James swarbrick’s “Physical Pharmacy”, 3 rd edition ,Varghese publishing house, Mumbai .1991,374. 21

PowerPoint Presentation: 

The Cooper and Gunn’s “Dispensing Pharmacy”, 6 th edition ,CBS publisher and distributors NEW DELHI,126. Bentley’s “Textbook of Pharmaceutics” ,8 th edition edited by,E.A.Rawlin , bailliere London 1995,44. www.google.com . Raymond C. R.,Paul J.S., Paul J. W.,2003, “Handbook of Pharmaceutical Excipients ”, fourth edition,447. Govarikar V. R.,Viswanathan N. V., “Polymer Science” 142,143. 22

PowerPoint Presentation: 

23 Ask alwaysWhy