Pharmaceutical Processings in Ayurveda and way out with core science

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Principles of Pharmaceuticals Processing of Herbal and Mineral Drugs :

Principles of Pharmaceuticals Processing of Herbal and Mineral Drugs Anand Chaudhary Associate Professor Department of Rasa Shastra Faculty of Ayurveda Institute of Medical Sciences Banaras Hindu University Varanasi email-anandayubhu@gmail.com

Ayurvedic Astuteness :

Ayurvedic Astuteness

Questions /Contents :

Questions /Contents 01- Are the principles of herbal drug processing and mineral drug processing same ? 02-Are there any parameters to know the physical change in source material ? 03-What are the reasons for selection of particular process of particular drug ? 04-What is the basis of selection of particular drugs for particular formulations ? CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 3

Contd.:

Contd. 05 -What is the relevance of repetition cycles especially for production of Bhasma and Khalviya rasa kalpa ? 06-Principles of Stability are based on what logic ? 07-Is there any co relation between principles of formulations applied to Ayurvedic drugs and modern drugs ? CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 4

Herbal Drug – Ayurvedic Medicine :

Herbal Drug – Ayurvedic Medicine CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 5

Authoritative Authentication :

Authoritative Authentication Classical considerations Contemporary contemplations CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 6

Sanitization & Storage :

Sanitization & Storage Separation Segregation Sustainable CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 7

Processing :

Processing CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 8

Container Consensus :

Container Consensus Primary dosage forms Secondary dosage forms CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 9

Comminution :

Comminution Size Reduction Mechanical Pressure Solvency Procedures CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 10

Extraction:

Extraction Universal Solvent Other Solutions Suspensions Nano suspensions Application of Energy CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 11

Energy Agenda :

Energy Agenda CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 12

Solvents:

Solvents CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 13

Completion Criteria :

Completion Criteria As per different dosage forms CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 14

Procurement & Packing :

Procurement & Packing As per Prepared Medicaments CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 15

Delivery & Dispensing :

Delivery & Dispensing As per indications of Physicians CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 16

Mineral Drug – Ayurvedic Medicine :

Mineral Drug – Ayurvedic Medicine CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 17

Classical Connotation :

Classical Connotation

Individualistic Identification:

Individualistic Identification Conventional connotations Current conjectures CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 19

Processing :

Processing CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 20

Contd .:

Contd . CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 21

Adaptations:

Adaptations Modification – Physical (Heterogeneous to homogenous) Chemical Conversion Enhancement CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 22

Impacts:

Impacts Purification Reduction in adverse effects Induction of trace elements Alteration in Constituencies CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 23

Metallographic findings :

Metallographic findings Metallographic figure of Raw Swarna Makshika (M= 400X) . Metallographic figure of Shodhita Swarna Makshika (M= 400X). CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 24

Initial Stride :

Initial Stride CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 25

Marana:

Marana Sukshmikaran (Fine powdering) Chakrika Nirmana (Pellet formation)- With other ingredients. Samputi Karana (Sealing in earthen vessels) Puta CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 26

Intrinsic Worth :

Intrinsic Worth Maximum Temperature range Duration of Maximum temperature Self Cooling Repetition of process 1 . Hardness 2. Particle size 3. Chemical Constituents CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 27

Vividness :

Vividness CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 28

Explicitness:

Explicitness 0 200 400 600 800 1000 1200 1 4 7 10 13 16 19 time in min. (1 = 15 units) temperature Temperature (0C) CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 29

Magnitude :

Magnitude Conversion Potentiation Elimination Safety CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 30

Makshika:

Makshika SEM Feature of Raw S. M SEM Feature of Bhasma S. M CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 31

Lauha Bhasma :

Lauha Bhasma CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune Neetu Singh et al , Chemical Characterization of Lauha Bhasma by X-Ray Diffraction and Vibrating Sample Magnetometry International Journal of Ayurvedic Medicine, 2010, 1(3), 143-149 25 July ,2011 32

Rasa Sindoor :

Rasa Sindoor Transmission electron microscopy (TEM) images (a, b, and c) along with selected area electron diffraction pattern (SAED) pattern (d) showing the presence of sub-micron size, agglomerated, and crystalline particles in the drug Rasa-Sindoor . S K Singh et al 2011 ,dept of Physics, BHU CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 33

Rasa Sindoor :

Rasa Sindoor Scanning electron microscopy (SEM) image of the Rasa-Sindoor showing the plate like porous surface morphology. Inset to the figure shows the tiny voids presents in the material, S K Singh et al ,2011, Dept of Physics ,BHU CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 34

Miscellaneous :

Miscellaneous Procurement Packing Dispensing CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 35

Recent Researches :

Manufacturing Characterization Safety & Efficacy CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune Recent Researches 25 July ,2011 36

Observations:

Scientific Approach Stakeholders Deptt of AYUSH,GOI Deptt of DST,GOI Academic Institutes Research Organizations ??????? Observations CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 37

Characterizations :

Characterizations IIT ,Rooraki Kumar A IIT, Mumbai Bellare Jayesh IIT ,Kharagpur Roy Subrato CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 38

Safety:

Safety Schedule Y , D & C Rule 1945 Rule 170 , D & C Rule 1945 – 24 Dec , 2008 CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 39

Rays of Radiance :

Rays of Radiance CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 40

Selective Selection :

Selective Selection Artificial Addition Inherent Innate CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 41

Supervises Solubility :

Supervises Solubility Developmental Doctrine Progressive Preferences CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 42

Probable Postulation :

Probable Postulation Bio accumulation Bio detoxification CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 43

Reductionist Relativity :

Reductionist Relativity Contour Conversion Eternal Endowment CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 44

Procedural Principal :

Procedural Principal Blending Thermodynamics CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 45

Assertive Assumptions :

Assertive Assumptions Visionary Validation Rational Realization CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 46

Extended Elegance :

Extended Elegance Explanation Elucidation CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 47

Prominent Paramount :

Prominent Paramount Herculean Herbal Metamorphic Metal CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 48

Absolve Absorption :

Absolve Absorption Organic Order Actual Accomplishment CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 49

Pragmatic Paradigms :

Pragmatic Paradigms Momentous Mercury Poise Parada CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 50

Authentic Authenticity :

Authentic Authenticity CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 51

Bhasma as Nano-medicine :

Bhasma as Nano -medicine Global Guidance Crucial Clause CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 52

Exceptional Embodiment :

Exceptional Embodiment

Stop Press:

Additional GMP Additional Certification Stop Press CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 54

Enlighten Endorsement:

Enlighten Endorsement Causative Consultation Comprehensive communication CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 55

Special Submission :

Special Submission CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 56

Exigency in Education :

Exigency in Education CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 57

Take Home Message :

Take Home Message Indian Inheritance Authoritative Agenda CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 58

Conclusion :

Conclusion Ayurveda is Super Science! Rasa Shastra is Super Chemistry! All is Well Dosage forms of Rasa Shastra & Bhaishjya Kalpana - Super Pharmaceutics ? CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 59

Acknowledgement :

Acknowledgement Prof A Wele ,Head , Dept of Rasa Shastra, College of Ayurveda, Bharati Vidyapeetha ,Pune All Team Rasa Shastra , BV ,Pune All Scholastic Scholars of Rasa Shastra at Pune from 25/07/2011 to 30/07/2011 CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 60

Thanks & All Good Wishes -----:

Thanks & All Good Wishes ----- CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 61

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