ascarids

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QUIZ #2 on….. , at 10:15!: 

QUIZ #2 on….. , at 10:15!

Order Strongyloidea: 

Order Strongyloidea

Order OXYURIDA: 

Order OXYURIDA Pinworms of the large intestine Adult worms have long tapering tail Host-specific Enterobius is a human pinworm Cats and dogs do NOT have pinworms Horses: Oxyuris equi

Oxyuris equis: 

Oxyuris equis HORSES large, white, thick-bodied adults

Slide6: 

Life-cycle of Oxyuris equi: Adult female in large intestine, migrates to the anus and deposits eggs in a sticky fluid on perianal area Fluid dries and flakes off with eggs Infective L3 mature within the egg shell in 4-5 days; ingested by the horse

Slide7: 

Life-cycle of Oxyuris equi: L3s in large intestine mature to adulthood Prepatent period ~ 5 months EGGS: single operculum

Slide8: 

Pathogenesis/Clinical signs: 1. large numbers of adults/larvae colitis 2. eggs/sticky fluid perianal itching bare ‘tailhead’

Slide9: 

Diagnosis: ‘scotch-tape’ pressed around perianal area; examine for operculated eggs Treatment: ivermectin or daily pyrantel

Order ASCARIDIDA (Ascarids): 

Order ASCARIDIDA (Ascarids) Adult worms are large! mouth surrounded by 3 fleshy lips Host-specific, relatively Toxocara canis in dogs Ascaris suum in pigs Parascaris in horses Baylisascaris in raccoons

Order ASCARIDIDA (Ascarids): 

Order ASCARIDIDA (Ascarids) Eggs are thick-walled (highly resistant), distinctive, contain a single cell. Can persist in soil for years!

Toxocara canis : 

Toxocara canis very common parasitic problem in dogs thick, white, large adult worms 50-180 mm long anterior end: cervical alae are expanded i.e. ‘arrowhead’ worms

Life-cycle of T. canis: 

Life-cycle of T. canis Adult worms live in the small intestine Female worms produce a large number of eggs..… 1 cell develops into an infective larva within the egg shell in ~4 weeks ‘EGG’ is ingested

Routes of infection: ADULT Dog: 

Routes of infection: ADULT Dog 1. Direct: Ingestion of infective egg containing L2 larva 2. Indirect: Ingestion of paratenic host which contains L2 larva

Slide18: 

LARVA ARREST “somatic migration” Development to adult “tracheal migration” 1. Direct: Ingestion of infective egg (L2 larva)

Routes of infection: ADULT Dog: 

Routes of infection: ADULT Dog 2. Indirect: Ingestion of paratenic host which contains L2 larva

Slide20: 

Routes of infection: FETUS or Newborn Reactivation of arrested larvae TRANSUTERINE infection Transmammary infection

Slide21: 

Prepatent period: 3 - 5 weeks ..........takes longer if infection starts with ‘egg’ stage vs. in utero infection/ingestion of paratenic host

Slide22: 

Pathogenesis & Clinical Signs: Large worms: inflammation hypersensitivity reactions physical effects Gastroenteritis Abdominal pain, pot-bellied, poor coat Fetid, mucoid diarrhea Respiratory signs are rare

Slide23: 

Diagnosis: Adult worms in vomitus or in feces Clinical signs Fecal * negative unless > 3-5 weeks*

Treatment and control:: 

Treatment and control: many choices of drugs against adults and larvae within the intestines drugs less effective against arrested larvae deworm dam + newborn puppies...start at 2-3 weeks till 2 months old clean the environment wash hands thoroughly after handling use bleach to clean dispose of feces

Zoonosis:: 

Zoonosis: visceral larva migrans migration of larvae in tissues Ocular larvae migrans, especially children granulomatous reaction to larvae in eye

Toxocara cati: 

Toxocara cati small intestine of cats similar to T. canis but … prominent cervical alae transmammary transmission is important No transuterine transmission both tracheal and somatic migration occur .....PPP is ~ 8weeks

T. cati: 

T. cati treatment of kittens from 6 weeks of age + Pyrantel, fenbendazole, ivermectin visceral larva migrans in humans

Toxascaris leonina: 

Toxascaris leonina small intestine of dogs and cats eggs oval, smooth

Toxascaris leonina: 

Toxascaris leonina infection by ingestion of eggs or infected paratenic host PPP 8-10 weeks mild clinical signs no visceral larva migrans

Baylisascaris procyonis: 

Baylisascaris procyonis Raccoons; may infect dogs with migration of raccoons to urban areas Visceral larva migrans

Parascaris equorum: 

Parascaris equorum small intestine of young horses < 2 yrs adult worms are large, thick-bodied

Parascaris equorum: 

Parascaris equorum only ONE route of infection i.e. ingestion of infective egg

Slide34: 

Egg containing infective larva (takes ~10-14 days) Larvae migrate to liver, lungs, coughed up and swallowed, returning to the small intestine 2-4 weeks after ingestion Prepatent period ~ 80 days

Slide35: 

Pathogenesis: 1. Respiratory problems - congestion due to parasite antigens/allergy - migration of larvae 2. Intestine - catarrhal enteritis, obstruction, perforation

Slide36: 

Clinical signs: diarrhea - odorous potbellied appearance rough hair coat *Suboptimal Growth* respiratory signs

Slide37: 

Treatment & Control: clean environment - adult worms are very fecund, eggs are very resistant and sticky! mare: clean teats & udder deworm foal at 2 months, q 2 months till ~1 year of age

If you suspect a heavy infection, do NOT use a potent drug at full dosage e.g. benzimidazole or ivermectin WHY? : 

If you suspect a heavy infection, do NOT use a potent drug at full dosage e.g. benzimidazole or ivermectin WHY?

LARGE worms impaction, anaphylaxis So, use a mild drug + mineral oil : 

LARGE worms impaction, anaphylaxis So, use a mild drug + mineral oil

Ascaris suum - PIGS: 

Ascaris suum - PIGS small intestine Eggs are thick shelled, rough, brownish, oval 1 female 200,000 eggs/day

Life-cycle of A. suum: 

Life-cycle of A. suum Only 1 route of infection: INGESTION of infective egg Larvae migrate, coughed up and swallowed back into the small intestine in 7-8 days p.i. Prepatent period ~ 60 days

Slide42: 

Pathogenesis: especially with repeated infections Lungs - hemorrhage, edema, eosinophils/cells Liver - focal fibrosis ‘milk spots’ Intestine - hypertrophy of muscle layer ( poor nutrient absorption)

Slide43: 

Clinical signs: coughing =‘thumps’, rapid, shallow, audible expiration stunted growth diarrhea (prepatent infection)

Slide44: 

Treatment & Control: clean environment - adult worms are very fecund, eggs are very resistant and sticky! deworm sows 2 weeks before farrowing & wash thoroughly most drugs work PYRANTEL kills newly hatched larvae use as feed additive

Slide45: 

Heterakis gallinarum “CECAL WORM” cecum of chicken, turkeys, etc. bird is infected either by: ingesting nematode egg/larvae OR infected earthworm Nematode is relatively NON-pathogenic but.....

Slide46: 

Heterakis gallinarum eggs & larvae carriers of a protozoa, Histomonas meleagridis severe ‘blackhead’ disease in turkeys (only; not in chickens) inflammation/necrosis of cecum & liver high mortality

Slide47: 

To control ‘blackhead’ disease, must control Heterakis nematode infections: * deworm * clean up the environment * don’t house turkeys with chicken, or use areas that previously housed chickens