impulsivity group

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IMPULSIVITYA Research Agenda to Clarify a Heterogeneous Folk Concept: 

IMPULSIVITY A Research Agenda to Clarify a Heterogeneous Folk Concept Lee Anna Clark Emil Coccaro Paul Links Larry Siever Roel Verheul Irwin Waldman

Core Features: 

Core Features Multiple models of impulsivity (e.g.): Self-report Motor -- Cognitive -- Non-planning Urgency -- Lack of Premeditation -- Lack of Perseverance -- Sensation-seeking Laboratory Response initiation -- Response inhibition -- Consequence Sensitivity

Current Measures: 

Current Measures Self-report BIS / UPPS (specific to impulsivity) SNAP / DAPP (general across PD) Laboratory IMT/CPT, Go/No-go, SKIP Clinically-relevant behaviors Life history, daily behaviors

Standards for Validity: 

Standards for Validity Test-retest stability Group discrimination Twin-heritability Convergent / discriminant validity

Standards for Validity: 

Standards for Validity Test-retest stability Group discrimination Twin-heritability Convergent / discriminant validity In sum, construct validity / Robins andamp; Guze criteria

How Well Meeting Standards?: 

How Well Meeting Standards? Hampered by variability across: measures methods labs units of analysis …

Recommendationsfor Future Research Agenda: 

Recommendations for Future Research Agenda To achieve consensus, need: To build on work done to date Workshops to bring together cross- disciplinary researchers Share results Design next-stage studies

Recommendationsfor Future Research Agenda: 

Recommendations for Future Research Agenda To move forward, need: Multi-method / multi-measure construct validation studies 1. within the 3 dimensions/domains 2. across all 3 dimension/domains simultaneously

Recommendationsfor Future Research Agenda: 

Recommendations for Future Research Agenda To move forward, need: Larger samples to cover the broadly relevant domain Multi-site interdisciplinary studies Strategies for external validation

Strategies for External Validation: 

Strategies for External Validation Genetic Behavioral (e.g., twin) Association studies Candidate gene andamp; whole genome Emerging technologies Proteomics ….

Strategies for External Validation: 

Strategies for External Validation 'Laboratory' / Experimental Approaches to identifying endophenotypes Psychophysiological Imaging Psychosocial tasks Neurochemical / Molecular

Strategies for External Validation: 

Strategies for External Validation Longitudinal Natural course / High risk familial symptom-based Treatment outcome Change mechanisms

Future Promise: 

Future Promise Analogous to success in other fields (e.g., diabetes, cancer research) BPDRF can facilitate: network development methodologic refinement working consortia (e.g., genetics) to establish feasibility for NIH funding

THANK YOU : 

THANK YOU