Presentation Transcript
IMPULSIVITYA Research Agenda to Clarify a Heterogeneous Folk Concept: IMPULSIVITY A Research Agenda to Clarify a Heterogeneous Folk Concept Lee Anna Clark
Emil Coccaro
Paul Links
Larry Siever
Roel Verheul
Irwin Waldman
Core Features: Core Features Multiple models of impulsivity (e.g.):
Self-report
Motor -- Cognitive -- Non-planning
Urgency -- Lack of Premeditation -- Lack of
Perseverance -- Sensation-seeking
Laboratory
Response initiation -- Response inhibition -- Consequence Sensitivity
Current Measures: Current Measures Self-report
BIS / UPPS (specific to impulsivity)
SNAP / DAPP (general across PD)
Laboratory
IMT/CPT, Go/No-go, SKIP
Clinically-relevant behaviors
Life history, daily behaviors
Standards for Validity: Standards for Validity Test-retest stability
Group discrimination
Twin-heritability
Convergent / discriminant validity
Standards for Validity: Standards for Validity Test-retest stability
Group discrimination
Twin-heritability
Convergent / discriminant validity
In sum, construct validity /
Robins andamp; Guze criteria
How Well Meeting Standards?: How Well Meeting Standards? Hampered by variability across:
measures
methods
labs
units of analysis …
Recommendationsfor Future Research Agenda: Recommendations for Future Research Agenda To achieve consensus, need:
To build on work done to date
Workshops to bring together cross-
disciplinary researchers
Share results
Design next-stage studies
Recommendationsfor Future Research Agenda: Recommendations for Future Research Agenda To move forward, need:
Multi-method / multi-measure
construct validation studies
1. within the 3 dimensions/domains
2. across all 3 dimension/domains
simultaneously
Recommendationsfor Future Research Agenda: Recommendations for Future Research Agenda To move forward, need:
Larger samples to cover the broadly
relevant domain
Multi-site interdisciplinary studies
Strategies for external validation
Strategies for External Validation: Strategies for External Validation Genetic
Behavioral (e.g., twin)
Association studies
Candidate gene andamp; whole genome
Emerging technologies
Proteomics ….
Strategies for External Validation: Strategies for External Validation 'Laboratory' / Experimental Approaches
to identifying endophenotypes
Psychophysiological
Imaging
Psychosocial tasks
Neurochemical / Molecular
Strategies for External Validation: Strategies for External Validation Longitudinal
Natural course / High risk
familial
symptom-based
Treatment outcome
Change mechanisms
Future Promise: Future Promise Analogous to success in other fields (e.g., diabetes, cancer research)
BPDRF can facilitate:
network development
methodologic refinement
working consortia (e.g., genetics)
to establish feasibility for NIH funding
THANK YOU : THANK YOU