5

The Nobel Prize1998 for their discoveries concerning nitric oxide (NO) as a signaling molecule in the cardiovascular system : 

The Nobel Prize 1998 for their discoveries concerning nitric oxide (NO) as a signaling molecule in the cardiovascular system B9503207陳又嘉 B9503212林佳美 B9503225葉佳宜 B9503230王馥陞 B9503232蕭名傑 B9503233張益嘉 B9403232張瑜顯

Slide2: 

(1.) Robert F.Furchgott 1980 年自然期刊 (Nature) EDRF 內皮衍生之舒張因子 (endothelium-derived relaxing factor )

Slide3: 

(2) Ferid Murad 1977 年環核甘酸研究期刊 (J Cycl Nucl Res) 硝化甘油是經由釋放NO而使得血管平滑肌放鬆的

Slide4: 

(3) Louis J Ignarro 1987年12月的美國國家科學院學報(Proc. Natl. Acad. Sci. USA) prove that EDRF = NO

Slide5: 

NO in our life 1. air pollution 2. acid rain The function of NO 1. a signal passing material in never system 2. regulate blood pressure and the flow of blood

Slide6: 

(1) Furchgott acetylcholine EDRF

Slide7: 

(2) Murad NO=========guanylate cyclase activatio GTP=========cGMP guanylate cyclase

(3) Louis J Ignarro Spectrophotometry: 

(3) Louis J Ignarro Spectrophotometry Hemoglobin (yellow) exposed to endothelial cells that were stimulated to produce EDRF (green) Hemoglobin (yellow) directly exposed to NO (green)

NO working mechanism: 

NO working mechanism

Slide10: 

Acetylcholine stimulates the endothelial cells to produce a factor, NO, which penetrates into and activates the muscle cells causing relaxation.

(I) 血管內皮 : 

(I) 血管內皮

控制一氧化氮製造量是調節一氧化氮活性的關鍵 : 

控制一氧化氮製造量是調節一氧化氮活性的關鍵

(II) 神經突觸 : 

(II) 神經突觸

For cardiovascular system: 

For cardiovascular system coronary artery 冠狀動脈 smooth muscle cells 平滑肌細胞

Slide15: 

atherosclerotic coronary artery. 冠狀動脈粥狀硬化 angina pectoris 心絞痛

Slide16: 

Nitroglycerin 硝化甘油

參考資料: 

參考資料 1. http://www.medlib.ncku.edu.tw/people/1998.html 2. http://www.tainandoctor.com/works_05.htm 3. http://www.mednobel.ki.se/ 4. http://www.nobel.se/medicine/laureates/1998/illpres/enzyme.html 5. http://www.nobel.se/medicine/laureates/1998/illpres/spectral.html 6. http://www.nobel.se/medicine/laureates/1998/illpres/sandwich.html 7. http://www.nobel.se/medicine/laureates/1998/illpres/index.html 8. http://www.nobel.se/medicine/laureates/1998/illpres/medicine.html 9. http://www.nobel.se/medicine/laureates/1998/illpres/application.html 10.http://www.nobel.se/medicine/laureates/1998/press.html 11.http://www.nobel.se/medicine/laureates/1998/medanim/images.html 12.http://www.nobel.se/ 13.http://nobelprize.com/ 14.http:// www.infoplease.com/ipa/A0777579.html/ 15.http://www.accessexcellence.org/WN/SU/SU102001/nobelbio.html 16.http://www.britannica.com/nobel/ 17.http://brc.se.fju.edu.tw/nobelist/199x/p1998.htm 18.http://www.biol.ntnu.edu.tw/doc/bill.htm