20071024125832215

Levamlodipine Besylate New CCB half dose, save efficiency and safety: 

Levamlodipine Besylate New CCB half dose, save efficiency and safety Dayi Hu, MD, FACC, FHRS, FESC Medical school of Tongji University, Shanghai People’s Hospital of Peking University,Beijing

Slide2: 

Amlodipine A typical modern long acting Ca2+ channel blocker with significant antihypertensive effect.

The antihypertensive effect in different age groups: 

The antihypertensive effect in different age groups

Significant antihypertensive effect: 

Significant antihypertensive effect *P<0.001

Outstanding antihypertensive effect: 

Outstanding antihypertensive effect Amlodipine vs. Lasartan P<0.001 n=97 n=93

Significant antihypertensive effect: 

Significant antihypertensive effect Amlodipine vs. ACEI , ARB (The Aged Hypertension) Amlodipine vs. ACEI, P=0.008 Amlodipine vs. ARB, P=NS

Slide7: 

The major heart terminals Incidence of heart disease Death of heart diseases All myocardial infarction All congestive heart failure All cerebral apoplexy Death caused by all the reasons New onset diabetes 0.5 1 2 VALUE Study: Julius S et al. Lancet. June 2004;363. Valsartan / Amlodipine

Slide8: 

Amlodipine is remarkably superior in reducing the rate of cerebral apoplexy compared to other antihypertensive drugs 40% 18% 16% 14% VS.Placebo VS.ACEI VS.ARB VS. Diuretic /β-Blocker PREVENT(n=825)/CAMELOT(n=1318)/IDNT(n=1136) Decrease of the risk of occurrence of cerebral apoplexy(%) ALLHAT(n=18102)/CAMELOT(n=1336) IDNT(n=1146)/VALUE(n=15245) ALLHAT(n=24309)/ASCOT (n=19257) Franz H. Messerli et al. Hypertension. 2006;48:359-361.

Amlodipine can effectively control early morning BP increase: 

Amlodipine can effectively control early morning BP increase Its consistent 24 hour antihypertension effect It’s superior than other CCB in decreasing the rate of early morning BP increase. C. Macchiarulo et al. Cur Ther Res Clin Exp. 2001;62:236-253. Before treatment Nifedipine 60mg QD N=20 Amlodipine 10mg QD N=20 Felodipine 10mg QD N=15 mmHg/H * P<0.05 * * SBP DBP Nifedipine 60mg QD N=20 Amlodipine 10mg QD N=20 Felodipine 10mg QD N=15 The speed of early morning BP increase before and after treatment After treatment

Levamlodipine (Shi Hui Da) : 

Levamlodipine (Shi Hui Da) Amlodipine is a racemic compound composed of levorotary and dextrorotary forms. The Ca2+ antagonist activity of levorotary form is approxim-ately 1,000 times of the one of dextrorotary form and twice of the one of racemic compound.. Levamlodipine: half dose --the same effect of racemic amlodipine. Less side effects. —— The New Generation Products of Amlodipine

Levamlodipine besylate (Shi Hui Da): 

Levamlodipine besylate (Shi Hui Da) Similar effectiveness in antihypertension? Safer? Equal organ protection effect? Amlodipine besylate (Norvasc) V.S.

One of the Clinical Studies: Levamlodipine vs Amlodipine : 

One of the Clinical Studies: Levamlodipine vs Amlodipine Chinese Journal of Medicine, 2002,37(5);46-47

Multi-center clinical study: 

Multi-center clinical study The People’s Hospital of Beijing University (Hu Dayi, PI) Capital Medical University Affiliated Beijing Tongren Hospital Capital Medical University Affiliated Beijing Youyi Hospital Capital Medical University Affiliated Beijing Xuanwu Hospital Sino-Japan Friendship Hospital Armed Police Contingent Hospital of Beijing The No. 3 Hospital of Beijing University Beijing Hospital Capital Medical University Affiliated Beijing Fuxing Hospital Beijing Willow Hospital

The trough / peak value of levamlodipine besylate (Shi Hui Da) : 

The trough / peak value of levamlodipine besylate (Shi Hui Da)

The changes of BP before treatment, after treatment and during drug holidays : 

The changes of BP before treatment, after treatment and during drug holidays CBP, n=80 *p<0.05: The value of SBP and DBP at the end of 8 weeks’ treatment compared with those of no drug administered. #p>0.05: The value of SBP and DBP after not administered for 24h or 48h compared with those at the end of 8 weeks’ treatment.

The reduction of SBP and DBP after eight weeks treatment in the two groups: 

The reduction of SBP and DBP after eight weeks treatment in the two groups

The SBP and DBP Changesduring drug holiday 1 after eight weeks treatment : 

The SBP and DBP Changes during drug holiday 1 after eight weeks treatment

The SBP and DBP Changes during drug holiday 2 after eight weeks treatment: 

The SBP and DBP Changes during drug holiday 2 after eight weeks treatment

Adverse Events (eight weeks treatment ): 

Adverse Events (eight weeks treatment )

Conclusion: 

Conclusion Both 2.5mg Levamlodipine besylate and 5mg Amlodipine besylate reduce BP effectively. The incidence of Levamlodipine adverse effects is low.

Conclusion: 

Conclusion CCB is the most common antihypertensive drug used in Chinese hypertensives. Levamlodipine besylate (Shi Hui Da) is both save and effective. Half dosage, Same effect and safety.

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Thanks！