Dasuni Nethanjalie Lelwala Gamacharige

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Research Directions in Nanomedicine

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1 Research Directions in NanoMedicine Dasuni Nethanjalie Lelwala Gamacharige Sri Lanka

Research Directions in NanoMedicine:

Research Directions in NanoMedicine Virtual Presentation by : Dasuni Nethanjalie Lelwala Gamacharige

Applications of Nanotechnology in a Clinical Context:

Applications of Nanotechnology in a Clinical Context Applications of nanotechnology in medicinal context includes, but not limited to the following areas. Diagnosis , Treatments Surgeries Signal conditioning Biomarker detection This enables enhanced , precise, efficient and personalized medicinal care for simple to more complex clinical conditions.

Ongoing Researches in Literature:

Ongoing Researches in Literature There are lot going on this area, listed below are few interesting ongoing researches. Crossing the Blood – Brain – Barrier (BBB) with magneto-electric particles Wireless stimulation of cells deep in brain using the Magneto-Electro-Nanoparticles (MENs ) S ignal conditioning and biomarker detection with nano enabled technologies Treatments to the disorders in Central Nervous System Cancer treatments

Open Research Directions - Suggestions :

Open Research Directions - Suggestions Early detection of and treatments to myocardial infraction aka heart attacks Placing a nanomachine near the heart which can detect the early signs of blood clots. The same machine can be improved to release the drugs to dissolve the clot. Periodic GP visits might need to refill the machine. Could be a minimally invasive method of treatment

Open Research Directions - Suggestions Contd…:

Open Research Directions - Suggestions Contd … Cancer Stem Cell (CSC) Theory to improve the nano -enabled The theory states that among all cancerous cells, there are few acting as stem cells and sustain the cancer by reproducing themselves. They give rise to metastases and are capable of acting as a reservoir of cancer cells that may cause a relapse after a surgery or chemotherapy has eliminate all observable signs of cancer. Therefore , the ultimate goal of the new cancer treatments should focus on destroying cancer stem cells. It has been identified that the behaviors and features of CSCs are closely resembling the normal stem cells. This knowledge can be used in mathematically modelling the malignant tumors.

Open Research Directions – Suggestions Contd… :

Open Research Directions – Suggestions Contd … Common platform to deliver drugs across Blood – Brain – Barrier There are ongoing researches in crossing BBB to treat disorders in Central Nervous System (CNS) There are different set of researches going on focusing the externally controlled target drug delivery It would be obviously advantageous to combine these two researches and form a common platform The future researches can then focus only on the remedy for a certain illnesses only Once the medicine is found, they have an already well built, efficient and effective method to deliver them to the CNS

Open Research Directions – Suggestions Contd… :

Open Research Directions – Suggestions Contd … Non – Invasive sensing of substances in blood Non-invasive optical sensing is generally performed by focusing a light beam onto a chosen site in the body and analyzing the reflected beam for the changes in wavelength, polarization or intensity. The chemical components of the body tissue (water, melanin, hemoglobin, fat, glucose, drugs, etc.) absorb light and make the transmission of light a function of thickness, color, structure of the skin, bone, blood and the substances in blood Researches have tried addressing this in the forms of Infrared spectroscopy, Raman spectroscopy, Fluorescent spectroscopy, Thermal spectroscopy, Optical Coherent Tomography, etc.

Non – Invasive sensing of substances in blood Contd… :

Non – Invasive sensing of substances in blood Contd … C oncentration of glucose, drugs and other substances is very low, making the acquisition of a precise absorption spectrum a challenging task. Absorption and scattering at the tissue prevents the incident light beam from following the shortest straight path. Defining the calibration models with respect to heart rate, skin pigmentation, osmolality of substances and body fluids, humidity and other related aspects is also a challenging work. Inhomogeneities of the biological tissue affects the modeling of optical energy transfer . I am proposing an embedded object placed in vein providing a unique signature and a focused beam of light which can be detected under minimal optical power. The biological tissue needs to be mathematically modeled to assist in the sensing task. Calibration models needs to be developed to enhance the accuracy and clinical usability of the proposed technique.

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Questions Please contact me for any questions, doubts or clarifications you would be having. You can reach me on the following contacts dasuni.lelwalagamacharige@monash.edu nethanjalie@gmail.com +61466044910

References:

References Ghasem Ghalamfarsa , Mohammad Hojjat-Farsangi , Mousa Mohammadnia-Afrouzi , Enayat Anvari , Shohreh Farhadi , Mehdi Yousefi & Farhad Jadidi-Niaragh (2016 ): Application of nanomedicine for crossing the blood–brain barrier: Theranostic opportunities in multiple sclerosis, Journal of Immunotoxicology Madhavan Nair, Rakesh Guduru , Ping Liang, Jeongmin Hong, Vidya Sagar , Sakhrat Khizroev (2013): Externally controlled on-demand release of anti-HIV drug using magneto-electric particles as carriers, Nature Communications Subas C. Dinda , Gurudutta Pattnaik (2013): Nanobiotechnology -based drug delivery in brain targeting, Current Pharmaceutical Biotechnology Julius A. Edson, Young Jik Kwon (2016): Design, challenge, and promise of stimuli-responsive nanoantibiotics , Nano convergence

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