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Slide2: 

Recovery of Biological Products 10 Welcome to Cancún

Moctezuma and the gardner of paradise: 

Moctezuma and the gardner of paradise Quetzalcóatl (Kulkulcán) Moctezuma: Aztec Emperor 1440 –1469 50 flasks of chocolate/day

Creative efforts: 

Creative efforts Program excellence – subjects and attendees Core subjects – integrated process design Impact of genomics and proteomics Latest research and developments Opportunities for open discussion

You are here!: 

You are here! Activity centre Reef Mangroves Have fun!

Lessons from the past: 

Lessons from the past 1968 150 tons 75% protein p.a. 5,000 kgs whey/hour

Learning for the future: 

Learning for the future Cell and tissue engineering In silico models DNA microarray devices Downstream processing moves to the front

Conference Statistics - Subject Areas: 

Conference Statistics - Subject Areas Oral Workshop Poster Total Process 16 5 18 39 Validation     7 7 Chromatography 7 5 26 38 EBA 1 1 12 14 Membrane Filtration 1 3   4 Membrane Chromatography 1 3 4 Crystallization 2   1 3 Depth Filtration   1 1 2 Extraction 1 1   2 Refolding     2 2 Foam Fractionation   1   1 Magnetic Separations 1     1 Centrifuge     1 1 Centrifugal Precipitation Chromatography     1 1 Electrophoresis     1 1 Drum Vacuum Filter   1   1 Cryopreservation     1 1 Genomics 3     3 Combinatorial 3     3 Ligands 1   9 10 Transgenics 1   1 2 Cell and Tissue 1     1 Analytical 1     1 Total 40 20 82 142

Papers by product type: 

Papers by product type

What are we all doing?: 

What are we all doing?

Slide11: 

attendees 3 146 3 4 72 N. America 65% S. & C. America 1% Australasia 3% Europe 31% Australia Austria Belgium Canada Chile Cuba Denmark Finland France Germany Iceland Japan Korea New Zealand Portugal Slovenia Sweden The Netherlands UK USA

attendees: 

attendees New and repeat attendance 2 400 + Applicants 228 Attendees 129 participants from sponsors 144 Abstracts accepted RX

Xcaret – Thursday afternoon: 

Xcaret – Thursday afternoon

Recovery science: 

Recovery science ”...... from the very beginnings of chemistry until our own time, methods of separating substances have occupied a key position in this science .... and even today some of chemistry’s most important advances are linked to the invention of new methods for separating various substances.” Arne Tiselius, 1952 Archer Martin & Richard Synge

Academic – industry traditions: 

Academic – industry traditions Columbia University University - Göttingen General Electric Company Nobel Prize in chemistry – 1932 Mountaineering Skiing Flying Irving Langmuir

Alan Michaels: 

Alan Michaels

Recovery of Biological Products: 

Recovery of Biological Products First conference in 1981 Initiated under the auspices of the Engineering Foundation Second conference established the Series Co-sponsored in 1994 by the ACS Since 1999: ACS - BIOT is the organizational sponsor RECOVERY OF BIOLOGICAL PRODUCTS – CONFERENCE SERIES

Conferences in the Series : 

Conferences in the Series RECOVERY OF BIOLOGICAL PRODUCTS – CONFERENCE SERIES When will the next conference be?????

Past chairs: 

Past chairs RECOVERY OF BIOLOGICAL PRODUCTS – CONFERENCE SERIES Who’s next .........????

Conference locations: 

Conference locations Attendees RECOVERY OF BIOLOGICAL PRODUCTS – CONFERENCE SERIES Where will the next meeting be????

Initial steps, refolding: 1981 - 2001: 

Initial steps, refolding: 1981 - 2001 Extraction Number Expanded/Fluidized beds Number Number Cell lysis/disruption Number Refolding RECOVERY OF BIOLOGICAL PRODUCTS – CONFERENCE SERIES

Unit operations: 1981 -2001: 

Unit operations: 1981 -2001 Number Chromatography Number Membranes Number Membrane chromatography Number Electro-separations RECOVERY OF BIOLOGICAL PRODUCTS – CONFERENCE SERIES

Process modelling and control: 1981 - 2001: 

Process modelling and control: 1981 - 2001 Number Modelling, control, automation Number Analytical/On-line monitoring RECOVERY OF BIOLOGICAL PRODUCTS – CONFERENCE SERIES

New chemistry: 1981 - 2001: 

New chemistry: 1981 - 2001 Number Genetic solutions, tags Combinatorial chemistry RECOVERY OF BIOLOGICAL PRODUCTS – CONFERENCE SERIES

Transgenics, gene therapy: 1981 - 2001: 

Transgenics, gene therapy: 1981 - 2001 Number Transgenics Number Gene therapy RECOVERY OF BIOLOGICAL PRODUCTS – CONFERENCE SERIES

1981 – The inaugural year: 

1981 – The inaugural year Science and industry have come a long way to the present, diversified array of expression and production systems and from No approved recombinant products in 1981 to 15 in 1991 to around 100 approved products in 2001. Early topics such as Recovery of low MW products such as antibiotics, organic acids, and ethanol as well as waste treatment have essentially disappeared from the Recovery series. RECOVERY OF BIOLOGICAL PRODUCTS – CONFERENCE SERIES

A decade later - 1992: 

A decade later - 1992 RECOVERY OF BIOLOGICAL PRODUCTS – CONFERENCE SERIES

The New Millennium: 

The New Millennium RECOVERY OF BIOLOGICAL PRODUCTS – CONFERENCE SERIES

Sponsors: 

Sponsors Abgenix, Inc. Amersham Pharmacia Biotech Amgen Inc. Aventis Behring L.L.C. Aventis Pasteur Bayer Corporation Berlex Laboratories, Inc. BIA Separations d.o.o. Biogen, Inc. Bio-Rad Laboratories Inc. BioReliance Corporation Boehringer Ingelheim Pharma KG Corixa Corporation Dyax Corporation Eli Lilly and Company Genencor International, Inc. Genentech, Inc. Genetics Institute, Inc. Geneworks, L.L.C. Genzyme Corporation Genzyme Transgenics Corporation GlaxoSmithKline Immunex Corporation Integrated Biosystems, Inc. Kendro Laboratory Products, L.P. Life Technologies, Inc. Lonza Biologics plc Merck & Co., Inc. Merck KGaA Millipore Corporation; Millipore Bioprocessing Neose Technologies Novo Nordisk A/S Pall Biopharmaceuticals Pfizer Inc. ProMetic BioSciences, Inc. Sachem, Inc. Sartorius AG Sepragen Corporation Tosoh Corporation; Tosoh Corporation, GmbH Whatman International Ltd. Wyeth-Lederle Vaccines