logging in or signing up NMR diagnosis Spencer Download Post to : URL : Related Presentations : Share Add to Flag Embed Email Send to Blogs and Networks Add to Channel Uploaded from authorPOINTLite Insert YouTube videos in PowerPont slides with aS Desktop Copy embed code: (To copy code, click on the text box) Embed: URL: Thumbnail: WordPress Embed Customize Embed The presentation is successfully added In Your Favorites. Views: 1658 Category: Entertainment License: All Rights Reserved Like it (6) Dislike it (0) Added: October 15, 2007 This Presentation is Public Favorites: 3 Presentation Description No description available. Comments Posting comment... By: qatarneh (38 month(s) ago) Hello, Dear author of NMR Diagnosis, I am Dr Sharif Qatarneh, working at a Cancer Center. I use NMR imaging in the future and I will teach my colleagues about NMR. Could you let me download the presentation for the sake of cancer patients. Thanks Saving..... Post Reply Close Saving..... Edit Comment Close Premium member Presentation Transcript Slide1: NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY -an ideal tool for Diagnosis & Drug Design B. HASEENA BANU Asst.Professor,SriPadmavathi School of Pharmacy,Tiruchanoor,Tirupati More free powerpoints at http://www.worldofteaching.com CONTENTS: CONTENTS INTRODUCTION BASIC PRINCIPLE DIFFERENT TECHNIQUES APPLICATIONS OF NMR IN MEDICINE CLINICAL APPLICATIONS IN DIAGNOSIS DRUG DEVELOPMENT NMR Nobel prize laureatesINTRODUCTION: INTRODUCTION BASIC PRINCIPLE IN NMR Atomic nuclei – tiny magnets In external magnetic field - allign or oppose If irradiated with EMR of proper frequency – Resonance √ α βo PARAMETERS Chemical shifts Spin lattice relaxation timeDIFFERENT TECHNIQUES: DIFFERENT TECHNIQUES Based on nuclei H1 NMR C13 NMR F13 NMR & P31 NMR N15 NMR & O17 NMR CWNMR FTNMR 2D_NMR &3D_NMR COSY _CORRELATION SPECTROSCOPY MRI_MAGNETIC RESONANCE IMAGING ESR_ELECTRON SPIN RESONANCE SPECTROSCOPY APPLICATIONS OF NMR IN MEDICINE : APPLICATIONS OF NMR IN MEDICINE CLINICAL APPLICATION OF PROTON IMAGING IN DIAGNOSIS BRAIN Distinguishing gray matter & white matter Imaging posterior fossae, brain stem, spinal cord Detect demyelinating lesions, tumors, hemorrhages, infarctionsSlide6: ABDOMEN Metabolic liver disease Measures liver iron over load in hemochromatosis Focal areas of inflammation in chronic active hepatisis KIDNEYS Distinguishing renal cortex & medulla To evaluate transplanted kidney PELVIS Differentiates between Benign prostatic hyperplasia & prostatic carcinoma Detects bladder tumours Slide7: MEDIASTINUM, HILUM, LUNG Assessing abnormalities Respiratory gating HEART Tomographic images of heart muscle, chambers, valvular structures ECHO-PLANAR TECHNIQUE Discrimination between infarcted, ischemic & normal myocardium BREAST 3D-NMR & single-slice planar imaging in detecting breast abnormalities Slide8: MUSCULO SKELETAL SYSTEM Demonstrates Osteo myelitis, tumor metastasis in vertebral bodies & pelvic bones Images of muscles, tendons, ligaments BLOOD VESSELS & FLOW Atherosclerotic vascular disease Assess blood flow in major vessels. INVIVO SPECTROSCOPY Chemical shift phenomenon Diagnosis of rare disease to inborn errors- Mc Ardle’s syndrome INVIVO Analysis of Bone flouride content.PUTTING NMR IMAGING INTO PERSPECTIVE: PUTTING NMR IMAGING INTO PERSPECTIVE Eliminates risk of x-radiation Excellent spatial & contrast resolution Detecting diseases at earlier stagesNMR IN PHARMACEUTICAL RESEARCH: NMR IN PHARMACEUTICAL RESEARCH Leading technology for 3-D structure determination of bio-macromolecules Studying protein structure SAR by NMR – Novel lead compounds Chemical shift mapping – Structural information on the binding modes and site positions Molecular dynamics, conformational analysis SHAPES NMR – SOLVESlide11: Structural genomics Identifying gene products in disease Targets of drug design. Development of Novel drug delivery systems Enhancing HTS assays Thousands of compounds Cryogenic NMR technology / cryoprobes NMR Nobel Prize Laureates: NMR Nobel Prize Laureates The Nobel Prize in Physics 1943, Ohostern, USA – Discovery of magnetic moment of proton The Nobel Prizein Physics 1952- IsidorJ. Rafi,USA – Discovery of new methods for nuclear magnetic precision The Nobel Prize in Chemistry 1991 – Felix Bloch, USA and Edward M. Purcell, USA – Methodology of high resolution NMR. The Nobel Prize in Chemistry 2002 – Kurt Wuthrich, Switzerland – Determining 3-D Structure by NMR. The Nobel Prize in Medicine 2003 – Paul C. Lauterbur, USA and Peter Mans field, U.K. – Discoveries concerning MRI.THANKING YOU: THANKING YOU You do not have the permission to view this presentation. In order to view it, please contact the author of the presentation.
NMR diagnosis Spencer Download Post to : URL : Related Presentations : Share Add to Flag Embed Email Send to Blogs and Networks Add to Channel Uploaded from authorPOINTLite Insert YouTube videos in PowerPont slides with aS Desktop Copy embed code: (To copy code, click on the text box) Embed: URL: Thumbnail: WordPress Embed Customize Embed The presentation is successfully added In Your Favorites. Views: 1658 Category: Entertainment License: All Rights Reserved Like it (6) Dislike it (0) Added: October 15, 2007 This Presentation is Public Favorites: 3 Presentation Description No description available. Comments Posting comment... By: qatarneh (38 month(s) ago) Hello, Dear author of NMR Diagnosis, I am Dr Sharif Qatarneh, working at a Cancer Center. I use NMR imaging in the future and I will teach my colleagues about NMR. Could you let me download the presentation for the sake of cancer patients. Thanks Saving..... Post Reply Close Saving..... Edit Comment Close Premium member Presentation Transcript Slide1: NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY -an ideal tool for Diagnosis & Drug Design B. HASEENA BANU Asst.Professor,SriPadmavathi School of Pharmacy,Tiruchanoor,Tirupati More free powerpoints at http://www.worldofteaching.com CONTENTS: CONTENTS INTRODUCTION BASIC PRINCIPLE DIFFERENT TECHNIQUES APPLICATIONS OF NMR IN MEDICINE CLINICAL APPLICATIONS IN DIAGNOSIS DRUG DEVELOPMENT NMR Nobel prize laureatesINTRODUCTION: INTRODUCTION BASIC PRINCIPLE IN NMR Atomic nuclei – tiny magnets In external magnetic field - allign or oppose If irradiated with EMR of proper frequency – Resonance √ α βo PARAMETERS Chemical shifts Spin lattice relaxation timeDIFFERENT TECHNIQUES: DIFFERENT TECHNIQUES Based on nuclei H1 NMR C13 NMR F13 NMR & P31 NMR N15 NMR & O17 NMR CWNMR FTNMR 2D_NMR &3D_NMR COSY _CORRELATION SPECTROSCOPY MRI_MAGNETIC RESONANCE IMAGING ESR_ELECTRON SPIN RESONANCE SPECTROSCOPY APPLICATIONS OF NMR IN MEDICINE : APPLICATIONS OF NMR IN MEDICINE CLINICAL APPLICATION OF PROTON IMAGING IN DIAGNOSIS BRAIN Distinguishing gray matter & white matter Imaging posterior fossae, brain stem, spinal cord Detect demyelinating lesions, tumors, hemorrhages, infarctionsSlide6: ABDOMEN Metabolic liver disease Measures liver iron over load in hemochromatosis Focal areas of inflammation in chronic active hepatisis KIDNEYS Distinguishing renal cortex & medulla To evaluate transplanted kidney PELVIS Differentiates between Benign prostatic hyperplasia & prostatic carcinoma Detects bladder tumours Slide7: MEDIASTINUM, HILUM, LUNG Assessing abnormalities Respiratory gating HEART Tomographic images of heart muscle, chambers, valvular structures ECHO-PLANAR TECHNIQUE Discrimination between infarcted, ischemic & normal myocardium BREAST 3D-NMR & single-slice planar imaging in detecting breast abnormalities Slide8: MUSCULO SKELETAL SYSTEM Demonstrates Osteo myelitis, tumor metastasis in vertebral bodies & pelvic bones Images of muscles, tendons, ligaments BLOOD VESSELS & FLOW Atherosclerotic vascular disease Assess blood flow in major vessels. INVIVO SPECTROSCOPY Chemical shift phenomenon Diagnosis of rare disease to inborn errors- Mc Ardle’s syndrome INVIVO Analysis of Bone flouride content.PUTTING NMR IMAGING INTO PERSPECTIVE: PUTTING NMR IMAGING INTO PERSPECTIVE Eliminates risk of x-radiation Excellent spatial & contrast resolution Detecting diseases at earlier stagesNMR IN PHARMACEUTICAL RESEARCH: NMR IN PHARMACEUTICAL RESEARCH Leading technology for 3-D structure determination of bio-macromolecules Studying protein structure SAR by NMR – Novel lead compounds Chemical shift mapping – Structural information on the binding modes and site positions Molecular dynamics, conformational analysis SHAPES NMR – SOLVESlide11: Structural genomics Identifying gene products in disease Targets of drug design. Development of Novel drug delivery systems Enhancing HTS assays Thousands of compounds Cryogenic NMR technology / cryoprobes NMR Nobel Prize Laureates: NMR Nobel Prize Laureates The Nobel Prize in Physics 1943, Ohostern, USA – Discovery of magnetic moment of proton The Nobel Prizein Physics 1952- IsidorJ. Rafi,USA – Discovery of new methods for nuclear magnetic precision The Nobel Prize in Chemistry 1991 – Felix Bloch, USA and Edward M. Purcell, USA – Methodology of high resolution NMR. The Nobel Prize in Chemistry 2002 – Kurt Wuthrich, Switzerland – Determining 3-D Structure by NMR. The Nobel Prize in Medicine 2003 – Paul C. Lauterbur, USA and Peter Mans field, U.K. – Discoveries concerning MRI.THANKING YOU: THANKING YOU