Principles of Design of Experiments

Principles of Design of Experiments :

Principles of Design of Experiments Siva R Challa

BASIC PRINCIPLES OF EXPERIMENTAL DESIGN: Interventional studeis/Analytical studies/Clinical trials :

BASIC PRINCIPLES OF EXPERIMENTAL DESIGN: Interventional studeis/Analytical studies/Clinical trials Randomization Replication Local control Blinding of study

BASIC PRINCIPLES OF EXPERIMENTAL DESIGN: Interventional studeis/Analytical studies/Clinical trials :

Randomization In  randomized  controlled trials, the  research  participants are assigned by chance, rather than by choice, to either the experimental group or the control group. Randomization  reduces bias as much as possible.  Randomization  is designed to "control" (reduce or eliminate if possible) bias by all means BASIC PRINCIPLES OF EXPERIMENTAL DESIGN: Interventional studeis/Analytical studies/Clinical trials

BASIC PRINCIPLES OF EXPERIMENTAL DESIGN: Interventional studeis/Analytical studies/Clinical trials :

Replication Repetition of an experiment using same procedure with different set of subjects and at different times. Local Control It is the amount of balancing, blocking/ stratifying/grouping of the subjects or experimental units Grouping means assigning homogenous subjects to the groups. Blocking means assigning experimental groups to different blocks in such manner that the assigned subjects in each block is homogeneous BASIC PRINCIPLES OF EXPERIMENTAL DESIGN: Interventional studeis/Analytical studies/Clinical trials

Homogeneous and Heterogeneous population :

Homogeneous and Heterogeneous population

Blinding of study :

Blinding of study Blinding: the measurement of response made without knowledge of treatment type Works by balancing measurement error and preventing observational bias. Single blinding : Study subjects blinded Double blinding : Subjects and measurement takers blinded Triple blinding : subjects, measurement takers and investigator blinded