1 ZoonosesIntro Dunne

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By: rezheen (16 month(s) ago)

its very important subject

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Epidemiology and Control of Zoonotic Infections: 

Epidemiology and Control of Zoonotic Infections Center for Infectious Disease Preparedness University of California, Berkeley Spring 2005, Tuesdays 10:30am-12pm

Instructors: 

Instructors Ben Sun, DVM, MPVM bsun@dhs.ca.gov Gundula Dunne, DVM, MPVM gdunne@dhs.ca.gov Guest Lectures Jason Stull, DVM, MPVM Anne Kjemtrup, DVM, MPVM

Goals: 

Goals Importance of Zoonoses in Public Health Ecology and Natural History Prevention and Control

Organization: 

Organization 8 Weeks Presentation – Lecture – Questions Disease Coverage Multiple per lecture Examples Focus on animal aspects See references for additional reading

Requirements: 

Requirements Weekly reading Case Report Paper Oral Presentation

Oral Presentation: 

Oral Presentation Given at beginning of class Relevant to the lecture 10-15 minutes Identify disease Background Case Investigation Discuss Zoonotic Aspects Confidentiality (remove identifiers) Limited number of spaces

Paper: 

Paper DUE MARCH 1 Any zoonotic disease Double spaces, font size 12 No more than 5 pages Background Case Investigation Discuss Zoonotic Aspects Need a topic? Ask us

Class Schedule: 

Class Schedule Week 1 – Zoonosis Intro & TSE Week 2 – Rabies Week 3 – Classic Zoonoses Week 4 – Bioterrorism Week 5 – Vector-borne Diseases Week 6 – Parasitic Zoonoses Week 7 – Emerging Zoonoses Week 8 – Foodborne Illnesses

Epidemiology and Control of Zoonotic Infections Lecture 1 : 

Epidemiology and Control of Zoonotic Infections Lecture 1 January 18, 2005

Slide10: 

Part I: Introduction to Zoonoses Part II: Transmissible Spongiform Encephalopathies

Intro to Zoonoses: 

Intro to Zoonoses Definition Importance Etiologies Animal Examples Transmission Routes Life Cycles

Zoonoses: 

Zoonoses From the Greek: Zoon: Animal Noson: Disease Diseases and infections which are naturally transmitted between vertebrate animals and humans - WHO 1959

Zoonoses: 

Zoonoses Does NOT include Fish and reptile toxins Allergies to vertebrates Diseases in which animal-derived food serves as a vehicle (e.g. hepatitis A contaminated deli meat) Experimentally transmitted diseases

Zoonoses: 

Zoonoses > 250 zoonotic diseases 60% of US Household have ≥1 pet Multiple pets in the home Human-animal bond Exotic species as pets

Zoonoses: Common Diseases: 

Zoonoses: Common Diseases Frequency – (CDC, 2003) Salmonella 39,919 Lyme disease 18,991 West Nile (CNS) 2,862 Trichinosis 4

Zoonoses: 

Zoonoses Spectrum of Disease Severity Death = rabies Severe illness = plague Chronic illness = Q-fever Mild illness = psittacosis

Zoonoses: Importance: 

Zoonoses: Importance Economics Zoonotic disease are expensive Rabies post-exposure prophylaxis GI illness due to Salmonella or Campylobacter – lost productivity, medical costs Import/Export BSE – restriction on cattle Avian Influenza – restriction on chicken Travel/Globalization Decreased transit time - SARS Remote area accessibility

Zoonoses: Importance: 

Zoonoses: Importance Surveillance Animals are sentinels Prevention and Control Animal = key component Complications (e.g. Lyme disease) Unknown reservoirs (e.g. Ebola)

Zoonoses: Etiologic Classification: 

Zoonoses: Etiologic Classification Viral Bacterial Parasitic Mycotic

Zoonoses: Viral Examples: 

Zoonoses: Viral Examples * indicates covered in lectures

Zoonoses: Bacterial Examples: 

Zoonoses: Bacterial Examples * indicates covered in lectures

Zoonoses: Parasitic Examples: 

Zoonoses: Parasitic Examples * indicates covered in lectures

Zoonoses: Mycotic Examples: 

Zoonoses: Mycotic Examples Aspergillosis Blastomycosis Cryptococcosis* Dermatophytosis* Histoplasmosis Sporotrichosis * indicates covered in lectures

Zoonoses: Animal Species: 

Zoonoses: Animal Species Dogs & Cats Rabies Roundworm Ringworm Lyme Disease (dogs only) Cat Scratch Disease (cats only) Food Animals Salmonella E.coli Brucellosis

Zoonoses: Animal Species: 

Zoonoses: Animal Species Birds: Psittacosis West Nile Cryptococcus Reptiles, Fish, & Amphibians Salmonella Mycobacterium Wild Animals Hantavirus Plague Tularemia

Routes of Transmission: 

Routes of Transmission Direct Droplet or Aerosol Oral Contact Indirect Foodborne Water-borne Fomite Vector-borne Environmental

Zoonoses - Life Cycle : 

Zoonoses - Life Cycle ORTHOZOONOSES May be perpetuated in nature by a single vertebrate species E.g. rabies, brucellosis, anthrax

Zoonosis: Rabies Life Cycle: 

Zoonosis: Rabies Life Cycle Virus inoculation (bite) Salivary gland excretion

Zoonoses - Maintenance Cycle: 

Zoonoses - Maintenance Cycle CYCLOZOONOSES Requires more than one vertebrate species but no invertebrate host Most are cestodiases (tapeworm diseases) Taenia saginata and T. solium require man to be one of vertebrate hosts Others, such as hydatidosis, man is accidentally involved

Slide31: 

Life Cycle:                                                                                   

Zoonoses - Life Cycle: 

Zoonoses - Life Cycle METAZOONOSES Require both vertebrates and invertebrates to complete transmission All arboviral infections West Nile virus, Saint Louis encephalitis Some bacterial diseases Plague, many rickettsia Some parasitic diseases Leishmaniasis, schistosomiasis

Zoonoses: Metazoonoses : 

Zoonoses: Metazoonoses Invertebrate Host: Mosquitoes Vertebrate Host: Birds Incidental Hosts: HUMANS, horses, amphibians, other mammals

Risk Factors: 

Risk Factors Companion Animal Dogs & roundworm Rats & Rat Bite Fever Occupational Animal control workers & rabies Wildlife biologists & hantavirus Foodborne Raw meat & E.coli Unpasteurized dairy & Listeria

Risk Factors: 

Risk Factors Recreational Activities Camping & Lyme disease Farm Settings Sheep & Q-fever Cattle & Cryptosporidium Travel Maylasia & Nipha Australia & Hendra

Reportable Diseases of Animals: 

Reportable Diseases of Animals By veterinarian or other individual Reported to CA Department of Health Services Plague Rabies Reportable to the CA Department of Food and Agriculture Anthrax Brucellosis Glanders Listeriosis Rabies in livestock Venezuelan equine encephalomyelitis West Nile And more…

Zoonosis: Take Home Points: 

Zoonosis: Take Home Points Transmitted between animals and humans Zoonoses are common Animals part of everyday life Recognize the risk factors

Acknowledgements: 

Acknowledgements Dr. Bruno Chomel Dr. Ben Sun