logging in or signing up WP 2 6 1 IgE SANAS van Drunen Sevastian Download Post to : URL : Related Presentations : Share Add to Flag Embed Email Send to Blogs and Networks Add to Channel Uploaded from authorPOINTLite Insert YouTube videos in PowerPont slides with aS Desktop Copy embed code: (To copy code, click on the text box) Embed: URL: Thumbnail: WordPress Embed Customize Embed The presentation is successfully added In Your Favorites. Views: 79 Category: Entertainment License: All Rights Reserved Like it (0) Dislike it (0) Added: October 30, 2007 This Presentation is Public Favorites: 0 Presentation Description No description available. Comments Posting comment... Premium member Presentation Transcript Objective of workpackage: Objective of workpackage To better understand the genetic, molecular and cellular mechanisms of IgE function. Simplistic view on allergy : Simplistic view on allergy First allergen exposure Second allergen exposure However : IgE ≠ symptoms Slide3: Study of asymptomatic subjects and subjects with sensitization to Parietaria or birch pollen, a pilot study GA2LEN Network WP 2.6 Potential mechanisms targeted : Potential mechanisms targeted Cross linking of FcγRII on basophil Regulatory dendritic cell or T lymphocyte Genotype versus PhenotypeCross linking of FcγRII: Cross linking of FcγRII Andrew Saxon IgE - IgG fusion Allergen - IgG fusion ITAM versus ITIM Functional differences Genetic differences Regulatory functions: Regulatory functions DC required for effector phase DC function and regulatory T lymphocyte Functional differences Genetic differences SANAS (design 1): SANAS (design 1) Enrol 160 - 200 subjects 4 groups Sensitised to Birch pollen symptomatic asymptomatic Sensitised to Parietaria symptomatic asymptomaticSANAS (design 2): SANAS (design 2) Questionaires Skin prick test Serum samples IgE and IgG4 determination Basophils (active/passive) T regulatory cells Birch patients: Birch patients Clinical Groups Fokkens (Amsterdam) Bachert (Ghent) Kowalski (Lodz) Carlsen (Oslo) - Children Van Hage (Stockholm) Valenta (Vienna)Birch analysis (on site): Birch analysis (on site) Basophil activation status Fokkens (Amsterdam) Kowalski (Lodz) Regulatory T lymphocytes Fokkens (Amsterdam) Van Hage (Stockholm) Parietaria patients: Parietaria patients Clinical Groups Papadopoulous (Athens) - Children Todo-Bom (Coimbra) Passalacqua (Genua) Colombo (Palermo) Bresciani (Rome)Parietaria analysis (on site): Parietaria analysis (on site) Basophil activation status Colombo (Palermo) Bresciani (Rome)Central laboratories: Central laboratories Recombinant serum IgE and IgG van Ree (Amsterdam) Indirect Basophil cell line sensibilization Maurer (Berlin) – Parietaria Dauron (Paris) – Birch Coordination regulatory T lymphocytes Akdis (Zurich/Davos) Staph-related IgE BachertFuture prospects and food for thought: Future prospects and food for thoughtClinical observations: Clinical observations Pets in childhood IgE and cows milk Thanksgivings disease Asymptomatic Symptomatic Clinical observations: Clinical observations Pets in childhood IgE and cows milk Thanksgivings disease Asymptomatic Symptomatic Conversion to asymptomatic: Conversion to asymptomatic Immunotherapy and modulators PGE2 Vitamine D3 Stable dust Small interference molecules ITAM and ITIM Regulatory Cells Slide18: Thank you for your attention Coimbra Amsterdam Lodz Athens Paris Rome Berlin Genua Stockholm Ghent Davos Palermo Oslo Vienna You do not have the permission to view this presentation. In order to view it, please contact the author of the presentation.
WP 2 6 1 IgE SANAS van Drunen Sevastian Download Post to : URL : Related Presentations : Share Add to Flag Embed Email Send to Blogs and Networks Add to Channel Uploaded from authorPOINTLite Insert YouTube videos in PowerPont slides with aS Desktop Copy embed code: (To copy code, click on the text box) Embed: URL: Thumbnail: WordPress Embed Customize Embed The presentation is successfully added In Your Favorites. Views: 79 Category: Entertainment License: All Rights Reserved Like it (0) Dislike it (0) Added: October 30, 2007 This Presentation is Public Favorites: 0 Presentation Description No description available. Comments Posting comment... Premium member Presentation Transcript Objective of workpackage: Objective of workpackage To better understand the genetic, molecular and cellular mechanisms of IgE function. Simplistic view on allergy : Simplistic view on allergy First allergen exposure Second allergen exposure However : IgE ≠ symptoms Slide3: Study of asymptomatic subjects and subjects with sensitization to Parietaria or birch pollen, a pilot study GA2LEN Network WP 2.6 Potential mechanisms targeted : Potential mechanisms targeted Cross linking of FcγRII on basophil Regulatory dendritic cell or T lymphocyte Genotype versus PhenotypeCross linking of FcγRII: Cross linking of FcγRII Andrew Saxon IgE - IgG fusion Allergen - IgG fusion ITAM versus ITIM Functional differences Genetic differences Regulatory functions: Regulatory functions DC required for effector phase DC function and regulatory T lymphocyte Functional differences Genetic differences SANAS (design 1): SANAS (design 1) Enrol 160 - 200 subjects 4 groups Sensitised to Birch pollen symptomatic asymptomatic Sensitised to Parietaria symptomatic asymptomaticSANAS (design 2): SANAS (design 2) Questionaires Skin prick test Serum samples IgE and IgG4 determination Basophils (active/passive) T regulatory cells Birch patients: Birch patients Clinical Groups Fokkens (Amsterdam) Bachert (Ghent) Kowalski (Lodz) Carlsen (Oslo) - Children Van Hage (Stockholm) Valenta (Vienna)Birch analysis (on site): Birch analysis (on site) Basophil activation status Fokkens (Amsterdam) Kowalski (Lodz) Regulatory T lymphocytes Fokkens (Amsterdam) Van Hage (Stockholm) Parietaria patients: Parietaria patients Clinical Groups Papadopoulous (Athens) - Children Todo-Bom (Coimbra) Passalacqua (Genua) Colombo (Palermo) Bresciani (Rome)Parietaria analysis (on site): Parietaria analysis (on site) Basophil activation status Colombo (Palermo) Bresciani (Rome)Central laboratories: Central laboratories Recombinant serum IgE and IgG van Ree (Amsterdam) Indirect Basophil cell line sensibilization Maurer (Berlin) – Parietaria Dauron (Paris) – Birch Coordination regulatory T lymphocytes Akdis (Zurich/Davos) Staph-related IgE BachertFuture prospects and food for thought: Future prospects and food for thoughtClinical observations: Clinical observations Pets in childhood IgE and cows milk Thanksgivings disease Asymptomatic Symptomatic Clinical observations: Clinical observations Pets in childhood IgE and cows milk Thanksgivings disease Asymptomatic Symptomatic Conversion to asymptomatic: Conversion to asymptomatic Immunotherapy and modulators PGE2 Vitamine D3 Stable dust Small interference molecules ITAM and ITIM Regulatory Cells Slide18: Thank you for your attention Coimbra Amsterdam Lodz Athens Paris Rome Berlin Genua Stockholm Ghent Davos Palermo Oslo Vienna