Pregnancy Toxemia in Ewes and Does

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PREGNANCY TOXEMIA IN EWES AND DOES : 

PREGNANCY TOXEMIA IN EWES AND DOES BY RIASAT WASEE ULLAH DVM

ALSO CALLED AS….. : 

ALSO CALLED AS….. Ketosis Twin Lamb Disease Pregnancy Paralysis Ewe Sleepy Sickness

DEFINITION : 

DEFINITION Pregnancy Toxemia is a Metabolic disorder that occurs in does/ewes during the Late Stage of gestation. Does that have Low Energy levels are more susceptible to toxemia.

CONT… : 

CONT… Pregnancy Toxemia can occur in Young and Old does with good or poor body condition. Studies have shown, however, susceptibility to pregnancy toxemia to be higher in older, fatty animals carrying multiple fetuses.

RISK FACTORS : 

RISK FACTORS Multiple Fetuses Poor Quality of Ingested Energy Dietary Energy Level Genetic Factors Obesity Lack of good body condition or high parasite load Confinement - lack of exercise

PATHOGENESIS : 

PATHOGENESIS During pregnancy, the ewes/doe's body resorts to Another Source of Energy when carbohydrates are in low supply. This alternative source involves the production of glucose from other Non-Carbohydrate Substances to facilitate glucose availability to the fetuses ????????????????????????

CONT… : 

CONT… This mechanism of breaking down stored fats will consequently overwhelm the liver's capacity, result in hepatic lipidosis or fatty liver, and ultimately, Impair Liver Function. As the ewes/doe's body progresses in mobilizing more body fatty tissue, it will produce Highly Toxic Byproducts or Ketone Bodies that are released into the blood circulation, causing an increase in Hepatic Fat Accumulation.

SIGNS : 

SIGNS Little or no Appetite Depression Lethargy or Sluggishness Muscular Imbalance or Poor Coordination, known as Ataxia Grinding of Teeth Blindness Star Grazing

CONT… : 

CONT… Low blood glucose ……. 20-40 mg/dl Increase ketone bodies in blood and urine Coma and Death

DIAGNOSIS : 

DIAGNOSIS History Clinical Sign Typical Smell from Mouth Ketone Bodies in the Urine (using strips) Low blood Sugar Level (using strips)

DIFFERENTIAL DIAGNOSIS : 

DIFFERENTIAL DIAGNOSIS Hypocalcaemia Hypomagnesaemia Polioencephalomalacia Enterotoxaemia Rabies Listeriosis Lead Poisoning

TREATMENT : 

TREATMENT 60 to 90 ml of Propylene Glycol administered orally 2 to 3 times per day Administering Electrolyte solutions containing 5 percent Dextrose orally, intravenously, or subcutaneously is also recommended. Administration of Sodium Bicarbonate solution intravenously or orally is also used to treat ketoacidosis

CONT… : 

CONT… Consider the administration of vitamin B- complex intramuscularly and Probiotics orally.

PREVENTION : 

PREVENTION A good feeding management practice is needed at the late stage of pregnancy. During the last 6 weeks of gestation, provide grain as it is an essential source of carbohydrates

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