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PBT Profiler Helps Identify Persistent, Bioconcentrating and Toxic Chemicals: 

PBT Profiler Helps Identify Persistent, Bioconcentrating and Toxic Chemicals Workshop on PBT Reduction Activities and Opportunities, NEWMOA Web Conference Tuesday, Feb. 11, 2003 Ihab H. Farag, Sc.D., P.E. Hamel Professor of Innovation and Technology Chemical Eng Dept University of New Hampshire (UNH) Durham, NH 03824-3591,USA Phone: 1-603-862-2313, fax: 1-603-862-3747 email:ihab.farag@unh.edu

What is the PBT Profiler?: 

What is the PBT Profiler? Estimate Persistence, Bioconcentration Potential, and Fish Chronic Toxicity of a Chemical From the Structure Compares predictions to EPA regulatory criteria for PBT-related action under TRI and TSCA New Chemical Program (PMNs), and to international criteria Provides PBT-related data previously unavailable Measured data retrieved if available Predictions when data are lacking Useful when data are lacking about the chemical

PBT Profiler: Helps Identify Persistent, Bioconcentrating and Toxic Chemicals Agenda: 

PBT Profiler: Helps Identify Persistent, Bioconcentrating and Toxic Chemicals Agenda Chemicals and PBTs PBT Profiler PBT Profiler Demo Next steps

R&D Process - Status Quo: 

R&D Process - Status Quo Chemicals Meeting All the Desired Criteria Will Be Evaluated Based on Additional Criteria: Final Product Development

Chemicals in Commerce: 

Chemicals in Commerce Pesticides ~2000 Drugs, Cosmetics, Food Additives ~2,000 Industrial Chemicals ~80,000 On TSCA Inventory 2,000 new chemicals/year Relatively little Hazard data are available Stakeholders make chemical choices among competing products / processes Stakeholders are often forced to choose among chemicals without information on PBT tradeoffs. Which chemicals are PBTs?

Chemicals Are Considered PBTs If They Meet EPA and/or International PBT Criteria For: 

Chemicals Are Considered PBTs If They Meet EPA and/or International PBT Criteria For Environmental Persistence AND Bioconcentration Potential AND Toxicity

Persistence (P) Criteria and Color scheme in PBT Profiler: 

Persistence (P) Criteria and Color scheme in PBT Profiler

Bioconcentration (B) Criteria and Color scheme in PBT Profiler: 

Bioconcentration (B) Criteria and Color scheme in PBT Profiler

Fish Chronic Toxicity (T) Criteria and Color scheme in PBT Profiler: 

Fish Chronic Toxicity (T) Criteria and Color scheme in PBT Profiler

Which Chemical is a PBT?: 

Which Chemical is a PBT? A B C D

Status of the PBT Profiler: 

Status of the PBT Profiler Created by EPA to address the PBT Initiative Developed as a collaborative effort with industry (ACC, SOCMA, CCC) and NGOs (ED) Beta tested by more than 100 participants from industry, academia, and government Peer Reviewed following EPA’s Peer Review Guidelines and Peer Review is posted on EPA’s E-Docket http://cascade.epa.gov/RightSite/dk_public_home.htm, “quick search” for “PBT Profiler” Released to the public in Sept 2002 and available at no cost at www.pbtprofiler.net

Why EPA Is Making The PBT Profiler Available to Industry?: 

Why EPA Is Making The PBT Profiler Available to Industry? Help Industry Pre-Screen Chemical Alternatives Understand Potential PBT Characteristics Of Product Alternatives Under Consideration at R&D Understand Potential PBT Trade-offs of Alternatives Under Consideration Reduce Product Development Costs Stimulate the Development of Environmentally Preferable Products and Processes

Hazard-related Information from PBT Profiler: 

Hazard-related Information from PBT Profiler Once released, will chemical go to air, water, soil, sediment? How long will chemical stay in media? Will chemical present a hazard?

Slide14: 

PBT Profiler Environmental Media Compartments Air Sediment Water Soil

www.pbtprofiler.net: 

www.pbtprofiler.net

PBT Profiler: 

PBT Profiler

Slide17: 

PBT Profiler

Slide18: 

PBT Profiler (Input o-Xylene, CAS 95-47-6)

Slide19: 

PBT Profiler (o-Xylene, CAS 95-47-6)

Slide20: 

PBT Profiler (o-Xylene, CAS 95-47-6)

Slide21: 

PBT Profiler (Output o-Xylene, CAS 95-47-6)

Flag for Chemicals on PBT Lists Benz(a)anthracene (CAS 56-55-3) New TRI Reporting Threshold = 100 lbs: 

26 Flag for Chemicals on PBT Lists Benz(a)anthracene (CAS 56-55-3) New TRI Reporting Threshold = 100 lbs

Slide27: 

Benz(a)anthracene (CAS 56-55-3) New TRI Reporting threshold: 100 lbs

Limitations of the PBT Profiler: 

Limitations of the PBT Profiler Over 60% of the 80,000 Chemicals on the TSCA Inventory Can Be Profiled using the PBT Profiler Chemicals That Can Be Profiled (62%) Discrete organics Mixtures with representative component Chemicals That Should Not Be Profiled (38%) Complex products (e.g., distillates and rosin) Natural products (e.g., oils, tallow, and enzymes) Chemicals of unknown structure (e.g., reaction products, ores) Metals and metal salts Polymers 38% 62%

Chemicals That Should Not be Profiled Using the PBT Profiler: 

Chemicals That Should Not be Profiled Using the PBT Profiler Chemicals With Experimental Data - Don’t use predicted data when measured data exist! Inorganic Chemicals Chemicals that Rapidly Hydrolyze - Acid Halides; Isocyanates; Sulfonyl Chlorides; Siloxanes; alpha‑Chloro ethers. Note: hydrolysis products can be evaluated. Cationic salts of Group I, Group II, Transition metals, Actinide, and Lathanide Organo Metallic Compounds Highly Reactive Compounds High MW Compounds, polymers, chems w MW >1,000 Mixtures – Each substance in mixture can be evaluated Chemicals with Unknown or Variable Composition

Slide30: 

Mixed Xylenes (CAS 1330-20-7) Example of Flag for Mixtures

CAS 7439-97-6: 

CAS 7439-97-6

PBT Profiler Security and Anonymity: 

PBT Profiler Security and Anonymity All connections to the PBT Profiler are completely anonymous No user-entered or chemical information is purposefully or systematically written to a disk drive or other permanent storage device The only data collected are the number of PBT Profiles run

PBT Profiler User Quotes: 

PBT Profiler User Quotes “The PBT profiler is an excellent tool to add to my risk assessment of existing and new chemicals” “I will encourage my chemists to use it in their research projects in addition to the regulatory/tox assessment that I am responsible for.” “We think this is a useful tool... for new raw’s we will surely check it.” “This fits in well with our internal policy on lifecycle analysis and product stewardship.” “The PBT Profiler is an excellent instrument for a first screening of the potential impacts of substances”

P2 & PBT screening in the absence of data PBT Comparison of Solvent A and Potential new Alternatives (B,C) All solvents have no data: 

P2 & PBT screening in the absence of data PBT Comparison of Solvent A and Potential new Alternatives (B,C) All solvents have no data High Moderate Low

The key to managing PBTs is Pollution Prevention: 

The key to managing PBTs is Pollution Prevention The EPA PBT Profiler is an excellent tool for Chemical Choosers and Chemical Formulators

PBT Profiler: Next Steps: 

PBT Profiler: Next Steps UNH Provides technology transfer and technical assistance in PBT Profiler Identify industry partners interested in using the PBT Profiler in case studies/success stories. Identify Small Business partners interested in using the PBT profiler in the decision making process.

PBT Profiler Contacts: 

PBT Profiler Contacts Ihab Farag, UNH ph: 603-862-2313 ihab.farag@unh.edu fax: 603-862-3747 Dwight Peavey, EPA R1 ph: 617-918-1829 peavey.dwight@epa.gov fax: 617-918-1810 Bill Waugh, USEPA ph: 202-564-7657 waugh.bill@epa.gov fax: 202-564-9063 Maggie Wilson, USEPA ph: 202-564-8924 wilson.maggie@epa.gov fax: 202-564-9063

Acknowledgment: 

Acknowledgment UNH efforts are funded by grants from EPA OPPT Bill Waugh 202-564-7657 Maggie Wilson 202-564-9063 Dwight Peavey 617-918-1829

Slide39: 

Thank you for your time.

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