logging in or signing up lecture1 lectures Rebecca Download Post to : URL : Related Presentations : Share Add to Flag Embed Email Send to Blogs and Networks Add to Channel Uploaded from authorPOINTLite Insert YouTube videos in PowerPont slides with aS Desktop Copy embed code: (To copy code, click on the text box) Embed: URL: Thumbnail: WordPress Embed Customize Embed The presentation is successfully added In Your Favorites. Views: 3446 Category: Entertainment License: All Rights Reserved Like it (7) Dislike it (0) Added: January 14, 2008 This Presentation is Public Favorites: 1 Presentation Description No description available. Comments Posting comment... By: vj_medhane (5 month(s) ago) Its very nice presentation will it be possible to download? allow me to download vj_medhane@rediffmail.com Saving..... Post Reply Close Saving..... Edit Comment Close By: asanthosh (7 month(s) ago) it's good! i like this presentation nithinraj.koochana@gmail.com Saving..... Post Reply Close Saving..... Edit Comment Close By: asanthosh (7 month(s) ago) its good! i like this presentation nithinraj.koochana@gmail.com Saving..... Post Reply Close Saving..... Edit Comment Close By: shridharsundaram (14 month(s) ago) I like this presentation. Can I have a powerpoint of this lecture? Gomathi Saving..... Post Reply Close Saving..... Edit Comment Close By: shonusree (16 month(s) ago) simple yet excellent presentation! Could you pl. allow me to download this presentation. Thanks sree Saving..... Post Reply Close Saving..... Edit Comment Close loading.... See all Premium member Presentation Transcript Lecture 1: Lecture 1 RetrosynthesisOrganic Synthesis: Organic Synthesis “The preparation of a desired organic compound from commercially available starting materials via some multi-step procedure” Used in: Pharmaceutical Agrochemicals Perfumes Dyes PolymersOrganic Synthesis: Organic Synthesis Q. Where do we start with complex molecules? A. Work backwards, starting from the product RETROSYNTHESISRetrosynthesis: Retrosynthesis “The analytical process of designing a synthetic route for the preparation of an organic compound from readily available starting materials.” Like a game of chess: Rules Learnable moves Underpinning strategies Practice makes Perfect!How will the course be taught?: How will the course be taught? Lectures Workshops/Tutorials Online Resources Practice Questions Worked Examples Quizzes Revision Videos Revision AidsOrganic Synthesis: Organic Synthesis Learning Outcomes: Use retrosynthetic analysis to devise a strategy for the synthesis of a target molecule Propose a detailed synthetic route to the target molecule from readily available starting materials Recommended Texts: “Organic Synthesis. The Disconnection Approach”. S. Warren. Wiley; 1982. “Organic Synthesis”. M. Wills and C. Willis. Oxford Primer, OUP; 1995 “Organic Chemistry” Clayden, Greeves, Warren and Worthers. OUP; 2001.Main considerations: Main considerations Construction of Carbon framework Requires good knowledge of C-C bond forming reactions Involves decisions about which bonds should be made Functional Group Interconversions (FGIs) Often require certain functional groups at certain stages in a synthesis E.g. Oxidation, Reduction, Hydrolysis Stereocontrol Often need to synthesise only one of a number of possible stereoisomers Only briefly touched on in this course Retrosynthesis: Retrosynthesis Designing a synthetic route by taking one or more backwards, or retrosynthetic, steps Definitions: Target Molecule – the molecule to be prepared Disconnection – analytical operation of breaking a bond, the reverse of a chemical reaction, to produce 2 synthons Synthon – an imaginary idealised fragment, usually an ion, corresponding to nucleophilic or electrophilic species Synthetic Equivalent – a real reagent that is equivalent to a certain synthon Functional Group Interconversion (FGI) – the operation of replacing one functional group with anotherRetrosynthesis: RetrosynthesisImportant Steps: Important Steps 1. Choosing the correct disconnection Corresponds to a reliable forward reaction Make use of functional groups Gives significant simplification: centre of molecule branch points symmetry Gives synthons with recognisable synthetic equivalentsImportant Steps: Important Steps 2. Assigning the charges to the synthons Consider both synthon pair options Make use of latent polarity Must correspond to reactive and available synthetic equivalents Available to buy Can easily be preparedToolKit - Carbon Electrophiles: ToolKit - Carbon ElectrophilesLecture 1: Summary: Lecture 1: Summary Introduction Main Considerations Definition of Terms Important Steps Carbon Electrophiles You do not have the permission to view this presentation. In order to view it, please contact the author of the presentation.
lecture1 lectures Rebecca Download Post to : URL : Related Presentations : Share Add to Flag Embed Email Send to Blogs and Networks Add to Channel Uploaded from authorPOINTLite Insert YouTube videos in PowerPont slides with aS Desktop Copy embed code: (To copy code, click on the text box) Embed: URL: Thumbnail: WordPress Embed Customize Embed The presentation is successfully added In Your Favorites. Views: 3446 Category: Entertainment License: All Rights Reserved Like it (7) Dislike it (0) Added: January 14, 2008 This Presentation is Public Favorites: 1 Presentation Description No description available. Comments Posting comment... By: vj_medhane (5 month(s) ago) Its very nice presentation will it be possible to download? allow me to download vj_medhane@rediffmail.com Saving..... Post Reply Close Saving..... Edit Comment Close By: asanthosh (7 month(s) ago) it's good! i like this presentation nithinraj.koochana@gmail.com Saving..... Post Reply Close Saving..... Edit Comment Close By: asanthosh (7 month(s) ago) its good! i like this presentation nithinraj.koochana@gmail.com Saving..... Post Reply Close Saving..... Edit Comment Close By: shridharsundaram (14 month(s) ago) I like this presentation. Can I have a powerpoint of this lecture? Gomathi Saving..... Post Reply Close Saving..... Edit Comment Close By: shonusree (16 month(s) ago) simple yet excellent presentation! Could you pl. allow me to download this presentation. Thanks sree Saving..... Post Reply Close Saving..... Edit Comment Close loading.... See all Premium member Presentation Transcript Lecture 1: Lecture 1 RetrosynthesisOrganic Synthesis: Organic Synthesis “The preparation of a desired organic compound from commercially available starting materials via some multi-step procedure” Used in: Pharmaceutical Agrochemicals Perfumes Dyes PolymersOrganic Synthesis: Organic Synthesis Q. Where do we start with complex molecules? A. Work backwards, starting from the product RETROSYNTHESISRetrosynthesis: Retrosynthesis “The analytical process of designing a synthetic route for the preparation of an organic compound from readily available starting materials.” Like a game of chess: Rules Learnable moves Underpinning strategies Practice makes Perfect!How will the course be taught?: How will the course be taught? Lectures Workshops/Tutorials Online Resources Practice Questions Worked Examples Quizzes Revision Videos Revision AidsOrganic Synthesis: Organic Synthesis Learning Outcomes: Use retrosynthetic analysis to devise a strategy for the synthesis of a target molecule Propose a detailed synthetic route to the target molecule from readily available starting materials Recommended Texts: “Organic Synthesis. The Disconnection Approach”. S. Warren. Wiley; 1982. “Organic Synthesis”. M. Wills and C. Willis. Oxford Primer, OUP; 1995 “Organic Chemistry” Clayden, Greeves, Warren and Worthers. OUP; 2001.Main considerations: Main considerations Construction of Carbon framework Requires good knowledge of C-C bond forming reactions Involves decisions about which bonds should be made Functional Group Interconversions (FGIs) Often require certain functional groups at certain stages in a synthesis E.g. Oxidation, Reduction, Hydrolysis Stereocontrol Often need to synthesise only one of a number of possible stereoisomers Only briefly touched on in this course Retrosynthesis: Retrosynthesis Designing a synthetic route by taking one or more backwards, or retrosynthetic, steps Definitions: Target Molecule – the molecule to be prepared Disconnection – analytical operation of breaking a bond, the reverse of a chemical reaction, to produce 2 synthons Synthon – an imaginary idealised fragment, usually an ion, corresponding to nucleophilic or electrophilic species Synthetic Equivalent – a real reagent that is equivalent to a certain synthon Functional Group Interconversion (FGI) – the operation of replacing one functional group with anotherRetrosynthesis: RetrosynthesisImportant Steps: Important Steps 1. Choosing the correct disconnection Corresponds to a reliable forward reaction Make use of functional groups Gives significant simplification: centre of molecule branch points symmetry Gives synthons with recognisable synthetic equivalentsImportant Steps: Important Steps 2. Assigning the charges to the synthons Consider both synthon pair options Make use of latent polarity Must correspond to reactive and available synthetic equivalents Available to buy Can easily be preparedToolKit - Carbon Electrophiles: ToolKit - Carbon ElectrophilesLecture 1: Summary: Lecture 1: Summary Introduction Main Considerations Definition of Terms Important Steps Carbon Electrophiles