Autonomic Nervous System and Pharmacology


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Presentation Transcript

Autonomic Nervous System and Pharmacology : 

Autonomic Nervous System and Pharmacology

4 groups : 

4 groups Effects on the Sympathetic Nervous System Stimulate Inhibit Effects on the Parasympathetic Nervous System Stimulate (same effects as inhibiting SNS) Inhibit (same effects as stimulating SNS)

Classifications : 

Classifications Sympathomimetics or Adrenergic agents Sympatholytics or Adrenergic antagonists Parasympathomimetics or Cholinergic agents Parasympatholytics or Anticholinergics or muscarinic blockers

Sympathomimetics or Adrenergic Agents-Primary Uses : 

Sympathomimetics or Adrenergic Agents-Primary Uses Alpha 1 receptor: Nasal congestion or hypotension; dilate pupils for ophthalmic exams 2 receptor: Hypertension Beta 1 receptor: Cardiac arrest, HF, and shock 2 receptor: Asthma and premature labor

Alpha 2 distinction : 

Alpha 2 distinction

Adverse Effects : 

Adverse Effects Seizures Tremors Dizziness Light sensitivity Dry mouth Hypertension Tachycardia Dysrhythmias Worsening of asthma Anorexia, Nausea, Vomiting Increased glucose Urinary Retention

Adrenergic agonists Nursing process : 

Adrenergic agonists Nursing process Assessment: Goals Implementation Client Teaching

Cholinergic Blockers : 

Cholinergic Blockers Mechanism: inhibit PNS Uses: treat peptic ulcer, IBS, increase HR, preanesthetic, asthma, dilate pupils Adverse: CNS stimulation, photophobia, dry eyes & mouth, decreased sweating, tachycardia, urinary retention Prototype: atropine

Overdose of Cholinergic Blockers : 

Overdose of Cholinergic Blockers Fever, visual changes, difficulty swallowing, psychomotor agitation, hallucinations. Hot as hades, blind as a bat, dry as a bone, mad as a hatter.

Adrenergic Antagonists Uses : 

Adrenergic Antagonists Uses HTN, including severe Dysrhthmias Angina Glaucoma Heart Failure Benign Prostatic Hypertrophy (BPH)

Alpha Adrenergic Blockers : 

Alpha Adrenergic Blockers Adverse effects Orthostatic hypotension Reflex tachycardia Nasal congestion Impotence Increased Parasympathetic activity

Beta Adrenergic Blockers : 

Beta Adrenergic Blockers Beta Blockers B1 B2 Therapeutic effects on cv system Decrease rate and force of contraction of heart and slow electriccal conduction through av node B1 (atenolol ex) cardioselective little effect on noncardiac tissue Nonselective such as propranolol has more SE Most common use is tx of htn

Nursing-Adrenergic Blockers : 

Nursing-Adrenergic Blockers Assessment Goals Implementation Evaluation

Cholinergic Agents (Parasympathomimetics) : 

Cholinergic Agents (Parasympathomimetics) Primary Uses: Increase urination Treatment of dry mouth Glaucoma MG Alzheimers Anticholinergic OD

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