logging in or signing up Leishmania Nevada Download Post to : URL : Related Presentations : Let's Connect Share Add to Flag Embed Email Send to Blogs and Networks Add to Channel Copy embed code: Embed: Flash iPad Dynamic Copy Does not support media & animations Automatically changes to Flash or non-Flash embed WordPress Embed Customize Embed URL: Copy Thumbnail: Copy The presentation is successfully added In Your Favorites. Views: 7692 Category: Entertainment License: All Rights Reserved Like it (7) Dislike it (0) Added: December 23, 2007 This Presentation is Public Favorites: 1 Presentation Description No description available. Comments Posting comment... By: pema_lhmo (5 month(s) ago) how we down load it!!!!! need it!! Saving..... Post Reply Close Saving..... Edit Comment Close By: kwkailashwagh (21 month(s) ago) please sent me ppt of leshmania, i want show it to my student, h i, i am DR WAGH DID md MICRO Saving..... Post Reply Close Saving..... Edit Comment Close By: nevrloly (30 month(s) ago) can i download it ???????? Saving..... Post Reply Close Saving..... Edit Comment Close By: mosi20 (37 month(s) ago) can i download this??!? i really need it!!!! Saving..... Post Reply Close Saving..... Edit Comment Close By: maysaa235 (42 month(s) ago) good Saving..... Post Reply Close Saving..... Edit Comment Close loading.... See all Premium member Presentation Transcript Fun with Flagellated Friends: Fun with Flagellated Friends Leishmania – Life cycle and social impactVector – The Female Sandfly: Vector – The Female SandflyReservoir Hosts: Reservoir Hosts Foxes, Jackals, Rodents, Wolves, Chickens, Horses And most importantly-- DOGSTwo Life-cycle stages: Two Life-cycle stages Promastigote -elongated, with flagella (10-20 µm long) -occur extracellularly in the insect midgut -motile Amastigote -round (3-7 µm diameter) -occurs intracellularly, during mammalian stage -nonmotileThe Blood Meal (fly becomes vector): The Blood Meal (fly becomes vector) Female sandfly bites a host (usually a nonhuman animal), intakes amastigotes through proboscis. Amastigotes reproduce via binary fission and transform in the sandfly’s midgut into promastigotes. How do promastigotes get from the gut back to the proboscis?Development Inside the Sandfly: Development Inside the Sandfly Repeated division blocks the fly gut, resulting in travel forward into the pharynx and blockage of the sucking apparatus Or Chitinolytic enzymes damage the fly cardiac valve, allowing for reverse flow into proboscisHuman Infection (AKA where did I put my insect repellent?): Human Infection (AKA where did I put my insect repellent?) Macrophage Lysis: Macrophage LysisMacrophage defenses: Macrophage defenses Oxidative burst peroxide (H2O2), superoxide anion (O2-) Acidification Enzyme Digestion Intracellular Survival: Intracellular SurvivalLeishmania defense mechanisms: Leishmania defense mechanisms Produces enzymes to neutralize the oxidative burst of the macrophage. Proton pump to keep the intracellular pH close to neutral. Surface glycoproteins that degrade lysosomal enzymes.Inactivation of oxidative burst products via enzyme action: Inactivation of oxidative burst products via enzyme action Superoxide dismutase O2- + O2- + 2H+ O2 + H2O2 Catalase or trypanothione peroxidase H2O2 + H2O2 O2 + 2H2O Surface glycoproteins: Surface glycoproteins LPG – inhibits oxidative burst; mediates attachment of promastigotes to gut wall. gp63 – degrades lysosomal enzymesCutaneous Leishmaniasis: Cutaneous LeishmaniasisMucocutaneous Leishmaniasis: Mucocutaneous LeishmaniasisVisceral Leishmaniasis: Visceral LeishmaniasisGlobal Status: Global Status You do not have the permission to view this presentation. In order to view it, please contact the author of the presentation.