PhytonutritionPresne tation

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“Overwhelming evidence... indicates that a plant-based diet can reduce the risk of chronic disease...there are components in a plant-based diet other than traditional nutrients that can reduce cancer risk. More than a dozen classes of these biologically active plant chemicals, now known as 'phytochemicals', have been identified-” Scientific basis of biomarkers and benefits of functional foods for reduction of disease risk: cancer, Joseph J. Rafter* Depart-ment of Medical Nutrition, Karolinska Institutet, NOVUM, S-141 86 Huddinge, Sweden Scientific Phytonutrition and Life-Long Wellness

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“When phytochemicals are added to the diet, the capacity of human genes to protect and restore optimal health is far greater than previously recognized.” McDaniel M.D., McAnalley, Ph.D., Journal of the National Academy for Child Development: The Role of Phytochemicals in Optimal Health, 1997 Vol. 11, No. 1 What the Experts Say

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“The Dietary Approaches to Stop Hypertension (DASH) diet substantially lowers blood pressure and reduces blood lipid levels. ... When compared with the control diet, the DASH diet is higher in flavonols, flavanones, flavan-3-ols, beta-carotene, beta-cryptoxanthin, lycopene, lutein+zeaxanthin, and phytosterols...It therefore is possible that the health benefits of the DASH diet are partially attributable to the phytochemicals and might extend beyond cardiovascular disease risk reduction.” –Most M. M., Estimated phytochemical content of the dietary approaches to stop hypertension (DASH) diet is higher than in the control study diet, J Am Diet Assoc. 2004 Nov;104(11):1725-7. What the Experts Say (Continued)

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What the Experts Say (Continued) “...fruits and vegetable phytochemical extracts exhibit strong antioxidant and antiproliferative activities ...from the combination of phytochemicals...the additive and synergistic effects of a "complex mixture" of phytochemicals...are responsible for these the benefits...no single antioxidant can replace the combination of natural phytochemicals....” -Lui RH, J Nutr.Potential synergy of phytochemicals in cancer prevention: mechanism of action. Department of Food Science, Cornell University, Ithaca, NY 148532004 Dec;134(12):3479S-85S.

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Importance of Diet Longevity is associated with increased consumption of fruits and vegetables(1) Chemicals in plants are called Phytochemicals. Scores of common plant foods, spices, and herbs have been shown to have metabolic activity in humans and have therefore been dubbed phytonutrients. These may be grouped into 7 classes: terpenes, phenols, polysaccharides, organosulfurs, organic acids, amines and lipids. Some are antioxidants Some support elimination/detoxification Some modulate immune function Some modulate hormone function (1) 1998 University of Naples Italy

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Importance of Diet “Men and women whose diets are high in fruits and vegetables were shown to have lower rates of angina, arthritis, asthma, bronchitis, cirrhosis, gall stones, heart attack, kidney stones and peptic ulcers.” Epidemiology March 1998 Vol. 9, No 2 p 208

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Oxygen Radical Absorbance Capacity. ORAC is a test tube analysis that measures the total antioxidant power of foods and herbs. High ORAC foods help our body to prevent most of the common diseases of aging, including cancer and heart disease. ORAC

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Dark greens, brightly colored plant foods and spices have the highest ORAC scores. 3,500 to 5,000 ORAC units are proven to have a significant impact on plasma and tissue antioxidant capacity. Generally, at least 7-9 servings of dark greens and brightly colored fruits and vegetables are needed to reach this level. ORAC

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Differing Antioxidant Activities

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Spirulina contains scores of vitamins, minerals, amino acids, enzymes and phytonutrients. Spirulina is 65-70% amino acid proteins. It is rich in B vitamins, iron, chromium, selenium and essential fatty acids. Spirulina is an excellent prebiotic. Prebiotics support friendly digestive organisms. The Super Greens: Spirulina

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Chlorella is a unique water green algae which contains high concentration of chlorophyll. Chlorophyll reduces the absorption of carcinogens (heterocyclic amines, polycyclic hydrocarbons, and aflatoxin). Chlorella assists in heavy metal and pesticide detoxification. The Super Greens: Chlorella

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The most nutritious of the green grasses. Barley grass contains a multitude of enzymes. Barley’s unique antioxidant, 2-0 glycosylisovitexin, is reported to have antioxidant activity equal or superior to vitamin E. It contains 13 times as much carotene as carrots, 55 times as much vitamin C as apples, and 5 times as much iron as spinach. The Super Green: Barley Grass

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Dark green “leafies” are nutrient dense in vitamins, minerals, carotenes, and the amine chlorophyll. Dark greens promote “alkalinization”, buffering excess acid. A rich source of lutein and zeaxanthin for retinal/macula health. The Super Greens: Spinach, Kale and Parsley

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Terpene rich foods high in orange and red carotenoids, like beta-carotene and lycopene, reduce the risk of many cancers. Carotenoids: Carrots and Tomatoes

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These are rich in organosulfur phytonutrient isothiocyanates, like sulphorafane, and indoles, such as Indole-3-carbinol or IC3. Broccoli, cauliflower, cabbage and brussel sprouts assist phase I and II detoxification in the liver, most notably metabolizing toxic estrogens. Thus regular cruciferous intake may help prevent certain types of uterine, cervical, prostate and breast cancers. The Cruciferous Vegetables

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Blueberries, raspberries, tart dark cherries and deep purple plums/prunes are the highest scoring ORAC fruits. Berries are rich in pigmented phenols: flavonoids and anthocyanins. Phenols help protect the cardio-vascular system, the brain, and the retina/macula. Grape seed extracts and pine bark extracts are powerful antioxidants shown to inhibit pre-cancerous lesions. Raspberries are high in ellagic acid, shown to lower cancer risk. The Berries

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Quercetin, found in green apple skins and onions, is a noted powerful antioxidant and antihistamine. Green tea contains several catechins that protect against heart and gum disease. Red wine is rich in the phenol stillbene resveratrol, which is thought to be largely responsible for the “French Paradox”. “PhytoActive ” is a broad spectrum of tea, fruit and vegetable extracts of concentrated phytonutrients of all the colors. More Phenol Flavonoids

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Friendly bacteria may prevent cancerous tumors, inactive viruses, produce natural antibodies and vitamins, and reduce cholesterol. Prebiotics support the growth of friendly bacteria. Spirulina is a prebiotic, as are the polysaccharide soluble fibers from fruit pectin, rice bran, and oat beta-glucan. The Prebiotics

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Amylase, lipase, cellulase, lactase, protease, bromelain and papain. These help digest starches, fats, cellulose, milk, sugar and proteins, respectively. These also tend to lower inflammatory proteins in the blood and tissue fluids. The Plant Enzymes

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Rice Bran is a phytonutrient and micro-nutrient dense soluble fiber polysaccharide. Apple pectin polysaccharide soluble fiber binds toxins and excess bile for elimination, which helps lower cancer risk and cholesterol. Oat beta-glucan is the most active ingredient in oat bran in lowering cholesterol and has immune modulation properties. Soluble and Insoluble Fibers

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Phosphatidyl choline (PC) is concentrated in the brain and the myelin sheets. Lecithin is a lipotropic (fat mover) assisting in reducing the risk of coronary heart disease and fatty liver. PC helps maintain memory by optimizing choline nutrition. Lecithin: 20% PC

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Milk Thistle flavins support liver regeneration and function. Cynarin from artichoke supports the liver as well. Red beet root terpene betacyns support both liver and kidney function. Cinnamon powder organic acids help normalize blood sugar. Aloe leaf 100-1 concentrate is rich in polysaccharide glyco-protiens with properties that promote healing. Herbs and Spices

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Phytonutrient Bioavailability “...the effort to understand the health benefits of plant foods... is the characterization of their physiologically active constituents, the phytochemicals...As our knowledge grows...we will learn how best to create new products through altering their concentrations, combinations and/or their bioavailability.” Functional Foods for Health Program, Department of Food Science and Human Nutrition, University of Illinois, Urbana, IL and * Mayer, J. USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA.

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“...antioxidants, which are found in many phytochemicals,... are biologically unstable, poorly soluble in water, and poorly distributed to target sites... we strongly advocate serious consideration of the bioavailability of dietary supplements... to improve their bioavailability using delivery systems such as liposomal formulations.” Yoko Shojia,b, and Hideki Nakashimaa, Nutraceutics and Delivery Systems, Journal of Drug Targeting, 12(6):385-391, 2004. Phytonutrient Bioavailability (continued)

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Liposome Structure

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Liposome Physiology

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In Vivo Bioavailability of Liposome Encapsulated Phytonutrients

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To learn more about phytonutrient functional foods and liposomal nanotechnology bioavailablity delivery science, please visit www.biopharmascientific.com To Learn More:

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These statements have not been reviewed by the FDA. No claim is made for NanoGreens10 for the treatment, diagnosis, or prevention of any disease. Disclaimer