china

Slide1: 

Ministry of Health, P.R.China 2006-1-20 China’s progress for potential pandemic preparedness

Slide2: 

Animal H5N1 Outbreak in China Mainland (2005～2006,1)

Slide3: 

death（6） hospital（1） recovery（2） 12.8，Liu xx 11.16，zhou X 11.23，Xu X 11.16，He X 12.6，Tang X 12.15，Guo X 12.29，Zhou X 1.9，Ouyang X 9 confirmed human cases Until 2006-01-20 12.6，Wei X

Human H5N1 isolates: 

Human H5N1 isolates

Slide7: 

HA

Results summary: 

Results summary all genes of these 5 viruses are avian influenza original, no evidences to show the recombination or reassortant between the avian and human influenza; the receptor binding specificity is still avian virus-like specific; the connecting peptide between HA1 and HA2 subunits is still multiple basic amino acids; all viruses are sensitive to M2 inhibitor and NA inhibitor drugs; the sequence of all virus isolates are very similar with the H5N1 avian influenza virus isolated from poultry in china.

Actions for avian influenza surveillance and control: 

Actions for avian influenza surveillance and control the national pandemic plan has been developed; a lot of activities are conducting from national to local levels; atypical pneumonia case reporting system has been strengthened, all 9 confirmed human cases were detected by this surveillance system; active surveillance conducted after the poultry outbreak happened; the capacity of the influenza laboratories including national and local level has been improved greatly;

Actions for avian influenza surveillance and control: 

Actions for avian influenza surveillance and control the influenza and human avian influenza surveillance system has been expanded to rural area, currently totally 198 sentinel hospitals and 63 influenza laboratories have been developed for the surveillance network in order to fast the information collection and sharing , China CDC has developed a professional human-avian influenza surveillance information system

Slide16: 

DDC,MOH WHO US CDC China CDC DCER office NIC Provincial CDC Prefecture CDC County CDC Lab Lab Sentinel Hospital Influenza Surveillance Network. China

Slide17: 

大 连 青 岛 宁 波 深 圳 厦 门 Expansion Surveillance Coverage: 198 Sentinel Hospitals in 31 provinces, from Oct 2005

Slide18: 

Laboratory Network in China

Education and training website: 

Education and training website

Actions for avian influenza surveillance and control: 

Actions for avian influenza surveillance and control 1000 staffs have got training in 2005, and more training courses are taking around the country

Actions for avian influenza surveillance and control: 

Actions for avian influenza surveillance and control the human H5N1 vaccine started the clinical trial I experiment

Slide24: 

Pandemic vaccine R&D Testing vaccines for clinical trial Immunization dosage: 1.25, 2.5, 5.0, 10.0 g/ml Type: Inactivated Pandemic Influenza Vaccine (whole virion, Al-absorbed) Immunization schedule: 0，28 day Based on the assays of various types, doses and schedules of immunization onto more than 3000 mice and rats, the strategies of the type, doses and immunization schedule of testing vaccine for clinical trial were almost have been done.

Actions for avian influenza surveillance and control: 

Actions for avian influenza surveillance and control close cooperation with WHO and other international organizations and other countries on avian influenza, MoH shared all information regarding the avian influenza virus with international society, such as sharing virus isolates with WHO, providing virus sequence to the international scientists.

Challenges: 

Challenges china is so big, there are 1.3 billion people and 70% living in rural area; the traditional agricultural mode gives more chance for people to get infection; there are not enough professional staff for the surveillance and control system, especially in local level; short of fund support, such as reagents and equipments supply for the local laboratories.

Suggestions : 

Suggestions information transparency; closer cooperation through international agency; support the basic research on virus ecology, transmission and pathology, et al; strengthen the public education on avian influenza basic knowledge; fast the vaccine and drug development.

Slide28: 

Thank you