nobel laureate public lecture 14 july 2005

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DEPARTMENT OF CHEMISTRY FACULTY OF SCIENCE 14 July 2005 (Thursday) 4 - 5 pm LT31 Blk S16 Level 3 Faculty of Science, NUS Host: Professor Tan Eng Chye, Dean of Science Public Lecture In conjunction with NUS Centennial and Shimadzu 130th Year Anniversary Celebrations Latest Mass Spectrometry Techniques and Their Use in Diagnosis of Diseases Abstract Various kinds of new technologies were presented, in about 2,700 oral and poster presentations, at the 53rd ASMS Conference on Mass Spectrometry held this year in San Antonio, Texas. Today, I would like to introduce some of the technologies and remarkable topics presented in the conference by Shimadzu, including some methods that will be possibly used in the diagnosis of diseases Shimadzu in the Front-Line of Cancer Research in Singapore Abstract In the battle to fight human cancers, Agenica Research was formed as a joint venture between the National Cancer Center of Singapore and two Japanese companies Mitsui and Shimadzu. A major contribution from Shimadzu is its expertise in proteomics, including its latest technologies in mass spectrometry and biotechnological instrumentations developed by Nobel Price Laureate Dr Koichi Tanaka. Breast cancer is the commonest cancer in Asian women. Agenica aims to identify the potential breast tumor markers by comparing the protein expression profiles among different human mammary cell lines and tissues. In this seminar I will introduce the large-scale and high-throughput proteomic platform used for the project, which included two-dimensional gel electrophoresis and MALDI-TOF mass spectrometry. Finally the biomarker candidates were shortlisted by an integrated proteomic and genomic approach.