Slide2:
Copyright © MedReviews, LLC. Weber MA, Fodera SM. Circadian variations in cardiovascular disease: Chronotherapeutic approaches to the management of hypertension. Rev Cardiovasc Med. 2004; 5:151. Reviews in Cardiovascular Medicine is a copyrighted publication of MedReviews, LLC. All rights reserved.
Typical 24-hour circadian pattern of BP in a normotensive individual. Reproduced with permission from Neutel et al. What are the approaches for evaluating antihypertensive treatment by 24 hour ambulatory blood pressure monitoring? Blood Press Monit. 1999;4:S23-S28.
Slide3:
Copyright © MedReviews, LLC. Weber MA, Fodera SM. Circadian variations in cardiovascular disease: Chronotherapeutic approaches to the management of hypertension. Rev Cardiovasc Med. 2004; 5:153. Reviews In Cardiovascular Medicine is a copyrighted publication of MedReviews, LLC. All rights reserved.
Ambulatory diastolic BP profiles produced by bedtime dosing of (A) COER-verapamil (Covera-HS®); data from Neutel et al. Novel delivery system for verapamil designed to achieve maximal blood pressure control during the early morning. Am Heart J. 1996;132:1202–1206. (B) CODAS-verapamil (Verelan® PM); adapted with permission from Smith et al. A new chronotherapeutic oral drug absorption system for verapamil optimizes blood pressure control in the morning. Am J Hypertens. 2001;14:14–19. (C) Graded-extended-release diltiazem (Cardizem® LA); adapted with permission from Glasser et al. Efficacy and safety of a once daily graded-release diltiazem formulation in essential hypertension. Am J Hypertens. 2003;16:51–58.