Types of Parentrals

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Presentation Transcript

Types of Parentrals : 

Types of Parentrals By : Mr. Mahesh Wamanrao Thube, Govt. College Of Pharmacy, A’Bad.

Content: At A Glance : 

Content: At A Glance 3 September 2010 Govt. College Of Pharmacy, Aurangabad 2 Classification Of Parenterals, Small Volume Parenterals: Defn & Components, Large Volume Parenterals: Defn & Introduction, Types of LVP, Examples Of IV fluids, Difference Between SVP & LVP, References

Classification Of Parenterals : 

Classification Of Parenterals 3 September 2010 Govt. College Of Pharmacy, Aurangabad 3

Small Volume Parenterals : 

Small Volume Parenterals USP Defn: An Injection that is packed in containers labeled as containing 100 mL or less Components of SVP Vehicle: 3 September 2010 Govt. College Of Pharmacy, Aurangabad 4

Slide 5: 

3 September 2010 Govt. College Of Pharmacy, Aurangabad 5

Large Volume Parenterals : 

Large Volume Parenterals Defn: LVP are Parenterals designed to provide -Fluid(water), -Calories(Dextrose soln), -Electrolytes(Saline soln), or -Combination of these. Volume 101-1000mL IV infusion technique is “Venoclysis”. 3 September 2010 Govt. College Of Pharmacy, Aurangabad 6

Requirements for LVP : 

Requirements for LVP Sterile, Non Pyrogenic, Free from Particulate matter Volume 101-1000mL, Single dose unit, No Preservative, Clear solution except Fat Emulsion, Isotonic, but Hypertonic also administered in TPN. 3 September 2010 Govt. College Of Pharmacy, Aurangabad 7

Types of Large Volume Parenterals : 

3 September 2010 Govt. College Of Pharmacy, Aurangabad 8 Types of Large Volume Parenterals

1.Hyperalimentation Solution : 

1.Hyperalimentation Solution Adm. Of large amt. of nutrients to patients who unable to take food orally, at caloric intake of 4000 kCal/day. Subclavian vein cannulation : Infusion of Hypertonic soln. Formulation : mix. Of Dextrose, Amino acids, Lipids, Electrolytes, & Vitamins. Use: 1.Adm. of Life saving/sustaining drug to Comatose patient. 2.Patient undergoing t/t of GI disease 3 September 2010 Govt. College Of Pharmacy, Aurangabad 9

Total Parenterals Nutrition : 

Total Parenterals Nutrition Modified term for Hyperalimentation Defn: IV adm. Of Caloric, Nitrogen, & other nutrients in sufficient qt. to achieve tissue synthesis & anabolism 3 September 2010 Govt. College Of Pharmacy, Aurangabad 10

Indication For Use of TPN : 

Indication For Use of TPN GI disease, Major trauma, Septicemia, Major Abdominal Surgery, Malignancy of Small Bowel, Radiation Enteritis, Chemotherapy & Radiotherapy, Bone Marrow Transplantation, Prolonged Coma. 3 September 2010 Govt. College Of Pharmacy, Aurangabad 11

2. Cardioplegic Solutions : 

2. Cardioplegic Solutions Are LVP used in Heart surgery to prevent injury to myocardium during reperfusion, as well as to maintain bloodless operating field. Maintains the Diastolic arrest. Adm. In cold form. Slightly alkaline to compensate Metabolic acidosis, Hypertonic Use: To minimize reperfusion injury resulting from tissue edema 3 September 2010 Govt. College Of Pharmacy, Aurangabad 12

3. Peritoneal Dialysis Solution : 

3. Peritoneal Dialysis Solution Infused continuously into abdominal cavity, bathing peritoneum & are then continuously withdrawn. Formulation:- Glucose , - Antibiotics as Prophylactic Use: Removal of toxic substances from body. To aid & accelerate excretion normal. To treat acute renal insufficiency 3 September 2010 Govt. College Of Pharmacy, Aurangabad 13

4.Irrigating solutions : 

4.Irrigating solutions To irrigate, flush & aid in cleansing body cavities & wounds. Certain IV soln(Normal Saline) may be used as irrigating soln, but soln designed as Irrigating soln should not be used Paretentrally. Use: treatment of serious wounds infused into blood stream. 3 September 2010 Govt. College Of Pharmacy, Aurangabad 14

Examples Of LVP fluids : 

Examples Of LVP fluids 3 September 2010 Govt. College Of Pharmacy, Aurangabad 15

Difference Between SVP & LVP : 

Difference Between SVP & LVP 3 September 2010 16

Continued.. : 

Continued.. 3 September 2010 Govt. College Of Pharmacy, Aurangabad 17

References : 

References Modern Pharmaceutics Fourth Edition, Revised and Expanded, Edited By G.S.Banker & C.T.Rhodes, Marcel Dekker pg387-389. The Science & practice of Pharmacy, By Remington, Vol-01, Edi.21st, Lippincott Publication, pg-838-840. Pharmaceutical Dosage Forms. Vol. 3 : Parenteral Medications, Pub Informa Healthcare, Edi. Avis, Kenneth E, Vol I, pg173-180 http://melindo.co.id/images/respiratory.jpg www.weiler-bfs.com 3 September 2010 Govt. College Of Pharmacy, Aurangabad 18

Thank You……….. : 

Thank You……….. 3 September 2010 Govt. College Of Pharmacy, Aurangabad 19