Ocular Drug Delivery System : Ocular Drug Delivery System Presented by : Mahesh W. Thube,
Dept. Of P’ceu,
GCP, Aurangabad. Human eye consist of :- : Human eye consist of :- Mechanism Of Ocular Absorption : Mechanism Of Ocular Absorption General Pathway For Ocular Absorption : General Pathway For Ocular Absorption Role Of Polymer In ODDS. : Role Of Polymer In ODDS. Solution Viscosity : Solution Drainage.
Polymer Mucoadhesive Vehicle: Retained in the eye due to non-covalent bonding between with conjuctival mucine.
Mucine is capable of picking of 40-80 times of weight of water. Factors Affecting Intraocular Bioavailability:
1. Inflow & Outflow of Lacrimal fluids.
2. Efficient naso-lacrimal drainage.
3. Interaction of drug with proteins of Lacrimal fluid.
4. Dilution with tears. Classification Of Ophthalmic Dosage Form: : Classification Of Ophthalmic Dosage Form: Ocular indication of controlled-release systems : Ocular indication of controlled-release systems Ocular Control Release System: Ophthalmic Inserts : Ocular Control Release System: Ophthalmic Inserts Definition:- Solid or Semisolid in nature,
- Placed in lower Fornix
- Composed of Polymeric vehicle containing drug.
Desired Criteria For Control Release Ocular Inserts. Types Of Ocular Control Release System : Types Of Ocular Control Release System A) Non-Erodible : : A) Non-Erodible : 1.Ocusert:
Developed by Alza Corporation,
Oval flexible ocular insert,
Annular ring : Impregnated with Ti02 : For Visibility 2) Contact Lens : : 2) Contact Lens : Presoaked Hydrophilic lens.
Drug Release : within 1st 30 Min.
Alternate approach : incorporate drug either as soln or suspension of solid monomer mixture.
Release rate is up to : 180 hr.
3) Diffusional Inserts :
Central reservoir of drug enclosed in Semi permeable or micro porous membrane for diffusion of drug.
Diffusion is controlled by Lacrimal Fluid penetrating through it.
It prevents continues decrease in release rate due to barrier.
Release follows : Zero Order Kinetics. B) Erodible Inserts : B) Erodible Inserts 1.Lacrisert:
Sterile, Rod Shaped device.
Composition: HPC without preservative.
Use:-Dry eye treatment, Keratitis Sica.
2.SODI: Soluble Ocular Drug Insert.
Small water soluble developed for Cosmonauts who could not use their eye drop in liquid condition.
Composition : Acryl amide, Vinyl Pyrolidone, Ethylacrylate.
Weight 15-16 mg.
In 10-15 sec Softens;
In 10-15 min. turns in Viscous Liquids;
After 30-60min. Becomes Polymeric Solution. Advantages of SODI : : Advantages of SODI : Single SODI application :replaces 4-12 eye drops Instillation,
or 3-6 application of Ointments.
Once a day treatment of Glaucoma & Trachoma.
It is made up of counter disc with Convex front & Concave back surface in contact with eye ball.
4-5mm in diameter.
Composition : Silicon based pre polymer.
Hydrophilic or Hydrophobic.
Drug release from 170 hr. C) Nanoparticle: : C) Nanoparticle: D) Liposome : D) Liposome Advances in ocular drug delivery : Advances in ocular drug delivery 1. Ophthalmic gel for pilocarpine
Poloxamer 407 (low viscosity, optical clarity, mucomimetic property)
2. Ophthalmic prodrug
Dipivalyl epinephrine (Dipivefrin)
Lipophilic increase in corneal absorption
Esterase within cornea and aqueous humor
3. Continuous delivery system based upon the osmotic property
Thin flat layer, contoured three-dimensional unit
Conform to the space of the upper cul-de-sac
Delivery of diethyl carbamazine in ocular onchocerciasis 4.Gel delivery system : 4.Gel delivery system Biodegradable polyisobutyl-cyano acrylate (PIBCA) colloidal particulate system of pilocarpine to incorporate it into a Pluronic F127 (PF 127)-based gel delivery system.
mucoadhesive polymer, the tamarind seed polysaccharide, as a delivery system for the ocular administration of hydrophilic and hydrophobic antibiotics. Reference: : Reference: N.K.Jain, Advances in Controlled & Novel Drug Delivery, CBS Publication, & distributor, New Delhi, pg No.219-223.
Remington & Gennaro ; The Science & Practice Of Pharmacy. Mack Publication Company. Easton, Pennsylvania. Pg. No. 1563-1567.
www.google/images/eye/anatomy& physiology Thank You....! : Thank You....! Creativity is allowing oneself to make mistakes.
Art is knowing which one to keep.