LopinavirRitonavir- A Promising Co-Formulated Drug

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Lopinavir/ritonavir combination is the first and only coformulated HIV-1 protease inhibitor. Clinical trials have demonstrated lopinavir/ritonavir’s immunologic and virologic benefits of treatment of HIV-infected adults, adolescents, and children. Recently, studies revealed that a combination of Lopinavir–Ritonavir were proven effective against SARS-CoV and MERS-CoV, the previous two coronaviruses that hit the globe.

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 Lopinavir/Ritonavir- A Promising Co-Formulated Drug :

  Lopinavir/Ritonav ir - A Promising Co-Formulated Drug

End of December 2019 and beginning of the year 2020 marked the emergence of, a novel coronavirus, designated SARS-CoV-2, and has caused an international outbreak of respiratory illness termed Covid-19. The full spectrum of Covid-19 ranges from mild, self-limiting respiratory tract illness to severe progressive pneumonia, multi-organ failure, and finally death. :

End of December 2019 and beginning of the year 2020 marked the emergence of, a novel coronavirus , designated SARS-CoV-2, and has caused an international outbreak of respiratory illness termed Covid-19. The full spectrum of Covid-19 ranges from mild, self-limiting respiratory tract illness to severe progressive pneumonia, multi-organ failure, and finally death.

Although there is no therapeutic treatment for coronavirus agents till date but in a hopeful finding, studies revealed that a combination of Lopinavir–Ritonavir were proven effective against SARS-CoV and MERS-CoV, the previous two coronaviruses that hit the globe. :

Although there is no therapeutic treatment for coronavirus agents till date but in a hopeful finding, studies revealed that a combination of Lopinavir– Ritonavir were proven effective against SARS- CoV and MERS- CoV , the previous two coronaviruses that hit the globe.

Originally, Lopinavir/ritonavir combination is the first and only coformulated HIV-1 protease inhibitor. Clinical trials have demonstrated lopinavir/ritonavir’s immunologic and virologic benefits of treatment of HIV-infected adults, adolescents, and children.:

Originally, Lopinavir / ritonavir combination is the first and only coformulated HIV-1 protease inhibitor. Clinical trials have demonstrated lopinavir / ritonavir’s immunologic and virologic benefits of treatment of HIV-infected adults, adolescents, and children.

Recently a random, controlled, open-label trial for lopinavir–ritonavir (ritonavir helps to stabilize lopinavir) in 199 hospitalized patients with severe COVID-19 was conducted and the drug showed benefit for some secondary endpoints. Pharmaceutical parlance, medicinal fraternity and researchers are trying ways to find a promising treatment for the deadly virus. A lot of research is going on throughout the world and a lot of hard work, knowledge, infrastructure, technology and research material is required to find a cure for COVID -19.:

Recently a random, controlled, open-label trial for lopinavir–ritonavir ( ritonavir helps to stabilize lopinavir ) in 199 hospitalized patients with severe COVID-19 was conducted and the drug showed benefit for some secondary endpoints . Pharmaceutical parlance, medicinal fraternity and researchers are trying ways to find a promising treatment for the deadly virus. A lot of research is going on throughout the world and a lot of hard work, knowledge, infrastructure, technology and research material is required to find a cure for COVID -19.

Some of the possible known and unknown impurities of Lopinavir required in clinical trials are tabulated below: :

Some of the possible known and unknown impurities of Lopinavir required in clinical trials are tabulated below: S.No . Product Name Chemical Name CAS No. 1. Lopinavir - API Lopinavir 192725-17-0 2. Lopinavir - Impurity T 2-(2,6-Dimethylphenoxy)-N-[(2S,3S,5S)-5-([[(2S,4S,5S)-5-[[(2,6-dimethylphenoxy)acetyl]amino]-4-hydroxy-1,6-diphenylhexan-2-yl] carbamoyl ]amino)-3-hydroxy-1,6-diphenylhexan-2-yl] acetamide 1797024-56-6

:

S.No . Product Name Chemical Name CAS No. 3. Lopinavir - Impurity S (2,6-Xylyloxy)acetyl Lopinavir 943250-65-5 4. Lopinavir - Impurity M (2S)-N-[(1R,3R,4S)-1-Benzyl-4-[[2-(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenylpentyl]-3-methyl-2-[2-oxotetrahydropyrimidin-1(2H)- yl ] butanamide NA 5. Lopinavir - Impurity L N,N′-(Z)-Ethene-1,2-diylbis[2-(2,6-dimethylphenoxy) acetamide ] NA

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S.No . Product Name Chemical Name CAS No. 6. Lopinavir - Impurity I (2S)-N-[(1S,2S,4S)-1-Benzyl-4-[[2-(2,6-dimethylphenoxy)acetyl]amino]-2-hydroxy-5-phenylpentyl]-3-methyl-2-[2-oxotetrahydropyrimidin-1(2H)- yl ] butanamide NA 7. Lopinavir - Impurity A (2S)-N-[(1S,3S,4S)-1-Benzyl-4-amino-3-hydroxy-5-phenylpentyl]-3-methyl-2-[2-oxotetrahydropyrimidin-1(2H)- yl ] butanamide 192726-05-9

:

S.No . Product Name Chemical Name CAS No. 8. 4,5-Dehydro(pyrimidin-2(1H)-one) Lopinavir 4,5-Dehydro(pyrimidin-2(1H)-one) Lopinavir NA 9. 3-Methyl-2-(2-oxo-tetrahydro-pyrimidin-1-yl)- pentanoic Acid{1-benzyl-4-[2-(2-6,-dimethyl-phenoxy)- acetylamino ]-3-hydroxy-5-phenyl-pentyl}-amide 3-Methyl-2-(2-oxo-tetrahydro-pyrimidin-1-yl)- pentanoic Acid{1-benzyl-4-[2-(2-6,-dimethyl-phenoxy)- acetylamino ]-3-hydroxy-5-phenyl-pentyl}-amide NA 10. (S)-N-[(2S,4S,5S)-5-Amino-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)- yl ) butanamide (S)-N-[(2S,4S,5S)-5-Amino-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)- yl ) butanamide 192726-05-9

:

S.No . Product Name Chemical Name CAS No. 11. (S)-N-((2S,4S,5S)-5-(2-(2,6-Dimethylphenoxy) acetamido )-4-hydroxy-1,6-diphenylhexan-2-yl)-2-(2,4-dioxotetrahydropyrimidin-1(2H)- yl )-3-methylbutanamide (S)-N-((2S,4S,5S)-5-(2-(2,6-Dimethylphenoxy) acetamido )-4-hydroxy-1,6-diphenylhexan-2-yl)-2-(2,4-dioxotetrahydropyrimidin-1(2H)- yl )-3-methylbutanamide 192725-39-6 12. (2S,3S,5S)-2-(2,6-Dimethylphenoxyacetyl)amino-3-hydroxy-5-trifluromethylcarbonylamino-1,6-diphenylhexane (2S,3S,5S)-2-(2,6-Dimethylphenoxyacetyl)amino-3-hydroxy-5-trifluromethylcarbonylamino-1,6-diphenylhexane NA

:

S.No . Product Name Chemical Name CAS No. 13. (S)-N-((2S,4S,5S)-4-(((6-( Cyclopropylamino )-9-((1S,4S)-4-( hydroxymethyl )cyclopent-2-en-1-yl)-9H-purin-2-yl)amino) methoxy )-5-(2-(2,6-dimethylphenoxy) acetamido )-1,6-diphenylhexan-2-yl)-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)- yl ) butanamide (S)-N-((2S,4S,5S)-4-(((6-( Cyclopropylamino )-9-((1S,4S)-4-( hydroxymethyl )cyclopent-2-en-1-yl)-9H-purin-2-yl)amino) methoxy )-5-(2-(2,6-dimethylphenoxy) acetamido )-1,6-diphenylhexan-2-yl)-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)- yl ) butanamide NA 14. (2S,3S,5S)-2-Amino-3-hydroxy-5-(tert-butyloxycarbonylamino)-1,6-diphenylhexane (2S,3S,5S)-2-Amino-3-hydroxy-5-(tert-butyloxycarbonylamino)-1,6-diphenylhexane 144163-85-9

Pharmaffiliates provides all the above-mentioned products for research and quality control purpose. In the critical time of pandemic, Pharmaffiliates assures to deliver on time and in a cost effective manner. We deliver all the research products with a Certificate of Analysis along with necessary data required to fulfill your regulatory needs.:

Pharmaffiliates provides all the above-mentioned products for research and quality control purpose. In the critical time of pandemic, Pharmaffiliates assures to deliver on time and in a cost effective manner. We deliver all the research products with a Certificate of Analysis along with necessary data required to fulfill your regulatory needs.

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