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VIRTUAL REGIONAL MEETING APRIL 14, 2005 ALASKA PRESENTATIONS George Happ - Alaska INBRE Jerry Mohatt - COBRE Director Larry Duffy, SNRP Director

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1917

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Recent history of NIH biomedical funding at University of Alaska

2001 Strategies to build biomedical research within the University: 

2001 Strategies to build biomedical research within the University Exploiting high latitude animal models. EPSCoR & SNRP Use convergence of UA expertise and special needs of Alaskans. COBRE/CANHR Start from historical themes and existing environmental expertise BRIN/INBRE

Alaska Senate Joint Resolution 44 Create a State S & T PlanBiomedical Research Target Priorities: 

Alaska Senate Joint Resolution 44 Create a State S & T Plan Biomedical Research Target Priorities Infectious disease Chronic disease Environmental health & toxicology Hibernation physiology and genomics Bioinformatics and systems biology

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NIH funding Where are we now at Univ Alaska?

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NIH SNRP Neuroscience L. Duffy $6 M 2000-2005 NIH INBRE Infectious Agents & Contaminants G. Happ $12M + 17.8M 2001-2009 NIH COBRE (CANHR) Diet, Diabetes, Heart Disease, Disparities G. Mohatt $12.5M 2001-2006 DOD DEPSCoR Physiology NSF EPSCoR Genetics & Physiology $27M 2001-2007 IDeA Network for Biomedical Research Excellence Center for Biomedical Research Excellence Specialized Neuroscience Research Center Experimental Program to Stimulate Competitive Research

“…to build and increase research capacity to help improve the health of Alaska Natives.”Jerry Mohatt, PI; Bert Boyer, co-PIPartners: University of Alaska Fairbanks, University of Alaska Anchorage, Yukon Kuskokwim Health Corporation: 

“…to build and increase research capacity to help improve the health of Alaska Natives.” Jerry Mohatt, PI; Bert Boyer, co-PI Partners: University of Alaska Fairbanks, University of Alaska Anchorage, Yukon Kuskokwim Health Corporation A Program of the University of Alaska Supported by the National Institutes of Health, National Center for Research Resources Biomedical and Behavioral Health Research with Alaska Natives at the University of Alaska: Present and Future Center for Alaska Native Health Research (CANHR)

Overall Goals of CANHR: 

Overall Goals of CANHR Current research foci: Obesity and its relationship to Diabetes & Cardiovascular Disease (COBRE) Multidisciplinary research projects integrating genetic, behavioral, and nutritional factors Develop culturally appropriate methods for prevention and reduction of obesity, diabetes, and cardiovascular disease (COBRE) Behavioral research: alcohol abuse, trauma, mental health and wellness (Other center supported applications). Increase NIH awards related to AK Native concerns

Participatory Approach of the Center for Alaska Native Health Research: 

Participatory Approach of the Center for Alaska Native Health Research Scientists and Community Partners Planning together Sensitivity to concerns of participants Ongoing communication Anticipation of problems and misunderstanding Return results to participants Cultural Education and Perceptiveness of researchers Genetic Education of communities

Organizational Structure of CANHR: 

Organizational Structure of CANHR CORE FACILITIES GENETICS CORE Genotyping Tech DNA Extraction DNA Banking Genotyping B. Boyer, Leader EPIDEMIOLOGY/ BIOINFORMATICS CORE Health Research Scientist (new FTE: interviewing) Biostatistician (R. Plaetke, Ph.D.) Field Research Coordinator D. Allison, Consultant Y-K Research Partner Village Research Assistants CULTURAL-BEHAVIORAL CORE Linguistic and cultural adaptations Cross-cultural communication G. Mohatt, Leader Augusto Legaspi, Ph.D. Eliza Orr. B.A. KNOWLEDGE APPLICATION & DISSEMINATION CORE Health Predictor Secondary Data Analysis Synthesis of Research Project Results Feedback to Native Communities B. Saylor, Leader EXTERNAL ADVISORY COMMITTEE ADMINISTRATIVE CORE YKHC/UA STEERING COMMITTEE INTERNAL ADVISORY GROUPS A. Steering Committee of faculty & staff B. Specific Advisory Groups for issues

Research focused in YK Delta: 

Research focused in YK Delta

Study Population: 

Study Population Study Sites: 6 villages & 1 small town in Alaska - 769 enrolled : 731 completed; 38 incomplete - 280 referrals for lipids, BP, FG levels. Analysis: 600 Participants out of first 614 entered (Excluded children, non-natives and 1 pregnant female) Recruitment Variation at Sites: Adults: 31-159, children: 1-22

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http://www.alaska.edu/canhr

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Quyana!

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Develop tenure track faculty Increase student research in Neuroscience Increase grant funding In Neuroscience UAF SNRP I Program Overview Specific Aim 4 Upgrade an existing tissue culture/imaging facility to state-of-the-art standards. Specific Aim 1 Develop an administrative core directly under the Provost that will provide the most effective environment to develop our neuroscientists. Specific Aim 2 Develop a research program around the theme of neuroprotective adaptations and increase collaborations with other neuroscientists on this theme. Specific Aim 3 Develop an emphasis on neuroscience education.

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SNRP II Vision for Neuroscience Research at UAF Capitalize on UAF research synergy Growing internal collaborations at UAF make this a real neuroscience program. Other areas of collaboration include stroke, nutrition, environment and biomedical engineering.

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Outcome for SNRP I SNRP I resulted in a stable research capability in neuroscience, which in turn led to the involvement of minority researchers and neuroscientists

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Confocal Microscopy Live video phase microscopy Live video fluorescence microscopy Calcium imaging Access Grid Node capability Optical Core Dr. Thomas Kuhn Optical Core Director SNRP II (2005)

Alaska INBRE  IDeA Network for Biomedical Research Excellence : 

Alaska INBRE IDeA Network for Biomedical Research Excellence Molecular Toxicology (BRIN 2001) [5 new faculty] Infectious Agents (INBRE 2004 -> ) [2 new faculty] Subsistence species Zoonotics Bioinformatics [2 new faculty]

The Alaska INBRE network of new facultyhires: 

Infectious agents INBRE search – UAA INBRE search - UAF The Alaska INBRE network of new faculty hires Molecular Toxicology Carol Jones – UAA Marvin Schulte – UAF Bioinformatics Tom Marr – UAF Naoki Takebayashi - UAF Tony Yeo – UAA Todd O’Hara – UAF Jon Runstadler - UAF

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Most contaminants in the Arctic originate in industrialized areas, are transported to the Arctic in the upper atmosphere, and are deposited in cold climates due to temperature-dependent condensation and precipitation. Arctic Monitoring and Assessment Program (AMAP) 1997 INBRE Theme #1 Molecular Toxicology

Carol Jones - UAA Toxicogenomics/Molecular Toxicology  Caveolin role in AHH receptor function: 

Carol Jones - UAA Toxicogenomics/Molecular Toxicology Caveolin role in AHH receptor function Dioxinbinds

Todd O’Hara - UAF Wildlife Toxicology : 

Todd O’Hara - UAF Wildlife Toxicology Research Biologist, North Slope Borough (9 years) Marine Mammal Consumption and Heavy Metals Bowhead Whale as Indicator for Monitoring Ecosystem Contaminants and nutrients in subsistence foods Contaminants and immune status-infectious agents (starting with polar bears and ice seals

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Homology Model of the 5-HT3 Receptor (Two of five subunits shown) Marvin Schulte – Neurotoxicology/neuropharmacology

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Denali Biomedical Workshop (August 2004) “Emerging pathogens at high latitudes” 40 investigators, 25 Alaska, 15 outside Recommended for priority areas of biomedical research: stress zoonotic diseases (tularemia, influenza, West Nile, brucellosis, etc.) strengthen microbial ecology in Alaska monitor insect and tick vectors expand immunology, immunogenetics, immunotoxicology

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? Tularemia – Molecular Epidemiology & Pathogenesis INBRE Theme #2 - Infectious Agents

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Avian Influenza- Ducks from Asia and North America transport viruses to Alaska – Do new strains appear?

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NIH CANHR NIH INBRE DEPSCoR NSF EPSCoR Biology (UAF/UAA/UAS) SFOS & IMS (UAF) ARSC Psychology (UAF) Biology & IAB (UAF) ICHS (UAA) Biology (UAF/UAA/UAS) Engineering (UAF/UAA) Chemistry (UAA/UAF/UAS) ARSC State Agencies & Construction Industry Fed Agencies ADF&G, DEC High Schools CDC, HHS, Health Corporations, Heath Providers •Biology •Chemistry •Engineering Partners NIH SNRP Biology & Biochemistry (UAF) [~$45M] [$27M] NIAID RCE -UWSOM