Hepatitis G Virus (HGV)/GB virus C (GBV-C)

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A short presentation for GB virus C, formerly known as Hepatitis G virus

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Hepatitis G Virus (HGV) GB virus C (GBV-C):

Hepatitis G Virus (HGV) GB virus C (GBV-C) Prepared by: Kho Jia Ming Ooi Kok Horng Year & Group : 3 rd year 1 st semester, Group 9 Teacher : Madam Медведева Ольга Анатольевна Department of microbiology, virology and immunology

Hepatitis G Virus (HGV) GB virus C (GBV-C):

Hepatitis G Virus (HGV) GB virus C (GBV-C)

History:

History

Hepatitis G Virus (HGV) GB virus C (GBV-C):

Hepatitis G virus (HGV ), which is now better known as HB virus C (GBV-C ) is a positive-strand RNA containing virus of the Flaviviridae family which has not yet been assigned to a genus, is known to infect humans, but is not known to cause human disease. Very little is known about the frequency of infection caused by HGV/GBV-C, the nature of the illness and preventive measures It is only known for sure that transfused blood containing the virus has caused some cases of hepatitis. Hepatitis G Virus (HGV) GB virus C (GBV-C)

Hepatitis G Virus (HGV) GB virus C (GBV-C):

Often patients with infection caused by HGV/GBV-C are also infected at the same time by hepatitis B virus and hepatitis C or both at the same time. In about 3 in every 1000 patients with acute viral hepatitis, HGV/GBV-C is the only virus present. The virus has been identified in as many as 20% of patients with long lasting viral hepatitis. Hepatitis G Virus (HGV) GB virus C (GBV-C)

Classification:

Group : Group IV + ssRNA Order: Unassinged Family: Flaviviridae Genus: Unassigned Species: GB virus C Classification

Genotypes of HGV/GBVC:

It is been proposed that there are 6 genotypes of HGV/GBVC. Genotype I is commonly found in Africa and is divided into 5 subtypes. Genotype II is commonly found in USA/Europe and is divided into 3 subtypes. Genotype III is commonly found in Asia. Genotype IV is commonly found in Southeast Asia. Genotype V is commonly found in South Africa. Genotype VI is commonly found in the Indonesia. A 7 th subtype have been described but details are not known. Genotypes of HGV/GBVC

Structure:

They are single stranded RNA containing virus. They has nucleocaspid surrounding the genome. The genome contain asingle open reading frame (ORF) encoding 2 structural (E1, E2) and 5 non-structural (NS2, NS3, NS4, NS5A, NS5B) proteins. Structure

Causes and symptoms:

• Most infected persons are asymptomatic. • Incubation period is unknown When diagnosed with HGV/GBVC infection, the infection is usually mild and brief. There is no evidence of serious complications but it is possible that, like other hepatitis virus, HGV/GBV-C can cause severe liver damage with results in liver failure. Causes and symptoms

Cultivation:

HGV/GBVC cannot be cultivated in tissue cell cultures or any other normal methods used for virus cultivation. In experiments, scientists have used living monkey and mice to study the disease development but it is also not widely used. Cultivation

Clinical characteristics:

The clinical significance of HGV/GBVC infection with respect to acute or chronic hepatitis is not well understood. HGV/GBVC RNA however, has been detected in patients with acute non-A to non-E viral hepatitis, in patients with chronic hepatitis of viral etiology, in cyptogenic cirrhosis patients and in some patients with primary hepatocelluar carcinoma. Clinical characteristics

Clinical characteristics:

Clinical characteristics

Transmission:

The virus is transmitted through infected blood materials. (Blood transfusion, sharing needles) Vertical transmission. (mother to feotus) By sexual contact. Transmission

Laboratory diagnosis:

Enzyme-linked immunosorbent assay ( ELISA) test is one of the method used. Recombinant immunoblot test. Polimerase assay method Polymerase chain reaction ( PCR ) • Currently, no serologic test is available. Laboratory diagnosis

Diagnosis:

Diagnosis

People that are at risk:

People that are at risk

Treatment:

Interferon. Ribavirin Combination of interferon and ribavirin Treatment

Prevention:

Absence of vaccine or any other specific prevention method. Non-specific prevention is used. Prevent sharing of personal items that might contain contaminated blood. Prevention

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