HAtrash

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Hani K. Atrash, MD, MPH Associate Director for Program Development National Center on Birth Defects and Developmental Disabilities Promoting the health of babies, children, and adults, and enhancing the potential for full, productive living Implementing Preconception Care Recommendations in Public Health Emerging Issues In Maternal and Child Health July 12, 2006

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Why do we need Preconception Care?

Adverse Pregnancy Outcomes Continue to be Higher Than Acceptable: 

Adverse Pregnancy Outcomes Continue to be Higher Than Acceptable

Progress in Preventing Maternal Mortality Slowed: 

Progress in Preventing Maternal Mortality Slowed 71% Decrease 13% Decrease

Low Birthweight Births Are Increasing: 

Low Birthweight Births Are Increasing 14.7% Increase Very low birthweigh births increased 25.9%

Preterm Deliveries Are Increasing: 

Preterm Deliveries Are Increasing 26% Increase Very preterm births increased 8.2%

Infant Mortality Rates Continue to be Very High: 

Infant Mortality Rates Continue to be Very High 52% Decrease 45% Decrease

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Infant Mortality Rankings (Ascending) – 1960-2002; Selected Countries (Health United States 2005)

Leading causes of Infant Death Have Changed – Maternal Complications Are Now Third Leading Cause of Infant Death: 

Leading causes of Infant Death Have Changed – Maternal Complications Are Now Third Leading Cause of Infant Death

Risk Factors Are Prevalent Among Pregnant Women and Women Likely to Become Pregnant : 

Risk Factors Are Prevalent Among Pregnant Women and Women Likely to Become Pregnant

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We Currently Intervene Too Late Critical Periods of Development 4 5 6 7 8 9 10 11 12 Weeks gestation from LMP Central Nervous System Central Nervous System Heart Heart Arms Arms Eyes Eyes Legs Legs Teeth Teeth Palate Palate External genitalia External genitalia Ear Ear Missed Period Mean Entry into Prenatal Care Most susceptible time for major malformation

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Early prenatal care is not enough, and in many cases it is too late!

Preconception Care: 

Preconception Care

Preconception Interventions:  Give protection: 

Preconception Interventions: Give protection Folic Acid Supplements: Reduce the occurrence of neural tube defects by two thirds Rubella Sero-negativity: Rubella immunization provides protective sero-positivity and prevents the occurrence of congenital rubella syndrome HIV/AIDS: timely antiretroviral treatment can be administered, pregnancies can be better planned Hepatitis B: Vaccination is recommended for men and women who are at risk for acquiring hepatitis B virus (HBV) infection.

Preconception Interventions:  Manage conditions: 

Diabetes: 3-fold increase in birth defects among infants of women with type 1 and type 2 diabetes, without management Hypothyroidism: Dosage of Levothyroxine should be adjusted in early pregnancy to maintain levels needed for neurological development Maternal PKU: Low phenylalanine diet before conception and throughout pregnancy prevents mental retardation in infants born to mothers with PKU Obesity: Associated adverse outcomes include neural tube defects, preterm birth, c-section, hypertensive and thromboembolic disease. STDs: have been strongly associated with ectopic pregnancy, infertility, and chronic pelvic pain. Preconception Interventions: Manage conditions

Preconception Interventions:  Avoid Teratogens: 

Alcohol use: Fetal alcohol syndrome (FAS) and other alcohol-related birth defects can be prevented. Anti-epileptic drugs: Some anti-epileptic drugs are known teratogens Accutane use: Use of Accutane in pregnancy results in miscarriage and birth defects Oral anticoagulants: Warfarin is a teratogen; medications can be switched before the onset of pregnancy Smoking: Associated adverse outcomes include preterm birth, low birth weight. Preconception Interventions: Avoid Teratogens

Clinical Practice Guidelines: 

Clinical Practice Guidelines American Diabetes Association (Diabetes -2004) American Association of Clinical Endocrinologists (Hypothyroidism – 1999) American Academy of Neurology (Anti-epileptic drugs) American Heart Association/American College of Cardiologists (Anti-epileptic drugs - 2003)

Recommendations: 

Recommendations March of Dimes American College of Obstetricians and Gynecologists American Academy of Pediatrics American Academy of Family Physicians American College of Nurse Midwives USPHS Expert Panel on the Content of Prenatal Care, 1989 Healthy People 2000 objectives

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Most providers don’t provide it Most insurers don’t pay for it Most consumers don’t ask for it Current Practice

Percent Eligible Patients Seen for Preconceptional Care by Type of Provider (2002-2003): 

Percent Eligible Patients Seen for Preconceptional Care by Type of Provider (2002-2003) CNM = Certified Nurse Midwives; OB/GYN = Obstetricians/ Gynecologists; F/GP = Family / General Practitioners;

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The CDC PCC Initiative: A Collaborative Effort of 22 CDC programs and over 35 National Organizations

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Recommendations to Improve Preconception Health and Health Care

Recommendations for Improving Preconception Health: 1&2 = Individual Responsibility: 

Recommendations for Improving Preconception Health: 1&2 = Individual Responsibility Recommendation 1. Individual responsibility across the life span. Encourage each woman and every couple to have a reproductive life plan. Recommendation 2. Consumer awareness. Increase public awareness of the importance of preconception health behaviors and increase individuals’ use of preconception care services using information and tools appropriate across varying age, literacy, health literacy, and cultural/linguistic contexts.

Recommendations for Improving Preconception Health: 3&4 = Prevention & Interventions: 

Recommendations for Improving Preconception Health: 3&4 = Prevention & Interventions Recommendation 3. Preventive visits. As a part of primary care visits, provide risk assessment and counseling to all women of childbearing age to reduce risks related to the outcomes of pregnancy. Recommendation 4. Interventions for identified risks. Increase the proportion of women who receive interventions as follow up to preconception risk screening, focusing on high priority interventions.

Recommendations for Improving Preconception Health: 5&6 = Interconception & Pre-pregnancy: 

Recommendations for Improving Preconception Health: 5&6 = Interconception & Pre-pregnancy Recommendation 5. Interconception care. Use the interconception period to provide intensive interventions to women who have had a prior pregnancy ending in adverse outcome (e.g., infant death, low birthweight or preterm birth). Recommendation 6. Pre-pregnancy check ups. Offer, as a component of maternity care, one pre-pregnancy visit for couples planning pregnancy.

Recommendations for Improving Preconception Health: 7&8 = Public Programs: 

Recommendations for Improving Preconception Health: 7&8 = Public Programs Recommendation 7. Health coverage for low-income women. Increase Medicaid coverage among low-income women to improve access to preventive women’s health, preconception, and interconception care. Recommendation 8. Public health programs and strategies. Infuse and integrate components of preconception health into existing local public health and related programs, including emphasis on those with prior adverse outcomes.

Recommendations for Improving Preconception Health: 9&10 = Research and Evaluation: 

Recommendations for Improving Preconception Health: 9&10 = Research and Evaluation Recommendation 9. Research. Augment research knowledge related to preconception health. Recommendation 10. Monitoring improvements. Maximize public health surveillance and related research mechanisms to monitor preconception health.

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Convening working groups to: Define “contents of preconception care” (3 and 4) Integrate existing clinical guidelines (3, 4, 5b, and 6b) Information dissemination: Develop key messages (1, 3, and 4) Create an information portals on the web (1) Catalogue existing materials (2c) Demonstrate the effectiveness: Evaluate existing models (5b and 8c) Conduct demonstration projects (3a, 4a, 5b, 5d, 5e, 8a, 8d, 9c, and 9e) Explore means for financing: Explore options for augmenting Medicaid waivers (7a) Conduct health plan demonstration projects (3h, 4f, and 6a) Augment CDC and other surveillance to monitor practice (10b, 10d, and 10f) Analyze existing data to further study association between women’s health and pregnancy outcomes (10) Complete a systematic review and a cost study (9a, 9c, and 9d) Steering Committee Meeting White Plains, NY - January 12-13 Priority Action Steps

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Thank You