SW BOF2005

Semantic Web for Life SciencesW3C: 

Semantic Web for Life Sciences W3C BOF 2005 ISMB

Agenda: 

Agenda What is SW? Current Activities Use Case Scenarios Resources What do we need to focus on next?

What is SW?: 

What is SW? RDF - Web-transportable descriptive model of all information OWL - Web Ontology Language; 3 levels of complexity/expressivity Focus on Semantic rather than Syntax Open world Graph model of all information on the Web Rules - SWRL

RDF-XML: 

DTD RDF-XML

Semantic Web for Life Sciences: 

Semantic Web for Life Sciences An Open Scientific Forum for Defining Cross-Disciplinary Life Science needs Show-Casing Working Examples Initiating SW Work Groups Capturing Best Practices Charter being completed Promote LSID awareness and use Sandbox for BioDASH demo and semantic lenses Identify Semantic Issues for CT and HC Recent members include Merck, caBIG/NCI, TeraNode

W3C Semantic Web for Life Sciences: 

W3C Semantic Web for Life Sciences Mission Statement The Semantic Web for Life Sciences (SWLS) Interest Group is chartered to facilitate use of Semantic Web in life sciences, drug discovery, and healthcare through the development of core vocabularies, implementation of unique identifiers, and discussion of implementations among users. The SWLS Working Group will also work with the other Semantic Web working groups and the Semantic Web Interest Group to gather suggestions for further SWLS development work and liaison with other Working Groups within the W3C and other organizations to promote the use of Semantic Web technologies and foster the growth of machine-readable, policy-aware data and databases in the life sciences.This work falls within the Technology and Society Domain.

Potential SW Applications: 

Potential SW Applications Data Integration and Aggregation Semantic Interoperability for Services Manage Terminology and Semantics of Communities Semantically Linking Scientific Literature Organization and Business Flow Modeling Manage Knowledge Assets: Randamp;D insights, IP Ref: 'A Life Science Semantic Web: Are We There Yet?' Science-STKE issue 283, pp. pe22, 10 May 2005

6 Proposed Objectives for SW in Life Sciences: 

6 Proposed Objectives for SW in Life Sciences Database Conversions and Transforms: query in SPARQL and retrieve in RDF Unique identifiers that are supported by the SW URI model Tools Conversant in RDF-OWL (Web-Services) Coordination and management of terminologies and ontologies: SW collaborative communities Knowledge-encoding practices: Named-Graphs for theories, hypotheses, models Semantics accounts and channels: store and share semantic annotations (based on RDF)

SWLS Current and Proposed Activities: 

SWLS Current and Proposed Activities Enabling (wrapping) Databases in RDF MolBio (NCBI, Uniprot), Pathways (BioPAX), RDB-Access, XML-RDAL, SPARQL Development and demonstration of the public tools Haystack, Simile, JENA, ? Need to define 'Context': Use cases? Types: Biological, Axiomatic, Experimental Named Graphs: http://www.wiwiss.fu-berlin.de/suhl/bizer/pub/Carroll_etall-TrustWorkshop-ISWC2004.pdf Public Semantic spaces (shareable annotations)

BioDASH Topic View: 

BioDASH Topic View Haystack Semantic Web Browser – MIT/IBM http://haystack.lcs.mit.edu

Tools: 

Tools RDB-RDF-Access - http://www.w3.org/2004/04/30-RDF-RDB-access/ http://www.w3.org/2004/10/04-pharmaFederate/ XML--andgt;RDF - http://www.w3.org/2005/02/13-KEGG/ Protégé - http://protege.stanford.edu/ SESAME - http://www.openrdf.org/ JENA - http://www.hpl.hp.com/semweb/jena2.htm SWOOP - http://www.mindswap.org/2004/SWOOP/

Demos/POCs: 

Demos/POCs BioDash/Haystack - http://www.w3.org/2005/04/swls/BioDash/Demo/ Simile/Longwell/Welkin - http://www.w3.org/2005/04/swls/simile/ myGRID-Taverna - http://taverna.sourceforge.net/ Connotea (NPG) - http://www.connotea.org/

Pathway Polymorphisms: 

Pathway Polymorphisms Identify targets with lowest chance of variance Predict parts of pathways with highest functional variability Map genetic influence to potential pathway elements Select mechanisms of action that are minimally impacted by polymorphisms

Pathway Semantic Lens example: 

Pathway Semantic Lens example add { :predicateSet rdf:type graph:CollectionPredicateSet ; rdf:type graph:PredicateSet ; dc:title 'BioPAX pathway arrows' ; hs:member biopax:NEXT-STEP ; hs:member :pointingTo ; hs:member ${ rdf:type vowl:RDFQueryLens ; vowl:sourceExistential ?s ; vowl:targetExistential ?t ; rdfs:label '' ; vowl:existentials @( ?s ?t ?type ) ; vowl:statement ${ vowl:subject ?type ; vowl:predicate biopax:LEFT ; vowl:object ?s } ; vowl:statement ${ vowl:subject ?type ; vowl:predicate biopax:RIGHT ; vowl:object ?t } } }

Multiple Ontologies Used Together: 

Multiple Ontologies Used Together Drug target ontology FOAF Patent ontology OMIM SNP BioPAX UniProt Extant ontologies Under development Bridge concept UMLS PubChem

Scales of Ontologies: 

Scales of Ontologies Large Vertical Models (UMLS, GO) – common semantics Small Locally-defined models – local definitions specific to organizations Bridging Ontologies – small semantics used to adjoin elements of other ontologies Ad hoc forms by individuals that are explorative and evolving

Power of Semantic Lenses in Research: 

Power of Semantic Lenses in Research Separates information collection and presentation from information processing: not all require coding! Database federation can be achieved using lenses Allows users to create powerful context-specific views of combined information, that can be annotated and shared Lenses do not require programming, can be extended, and can be shared/traded Less development time, more definition be scientists More can be achieved in less time and for less cost!

SIMILE-MIT: 

SIMILE-MIT Annotation Accounts Piggy-Bank plug-in for FireFox Welkin SW Graph viewer

New Regulatory Issues Confronting Pharmaceutics: 

New Regulatory Issues Confronting Pharmaceutics from Innovation or Stagnation, FDA Report March 2004 Support All Stakeholders Relate information from different platforms and different projects

What should we do next?: 

What should we do next? caBIG coordination Clarify LSID andlt;=andgt; RDF id relations Handling Ontology versioning Citation and references in LSIDs

How to become active?: 

How to become active? Mailing list - public-semweb-lifesci@w3.org Coordinate your projects with us Become a W3C member Semantic Web for Life Sciences www.w3.org/2005/04/swls