CWDPostprandialGlyce micControl200603

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Strike The Spike!: 

Strike The Spike! Strategies for Combatting After-Meal Highs Gary Scheiner MS, CDE

Overview: 

Overview Definitions Risks Detection Management

After-Meal Peaks Defined: 

After-Meal Peaks Defined The net rise that occurs from before eating to the highest point after eating. ADA Goal: <180 mg/dl 1-2 hrs after start of meal DCCT Goals: <180 mg/dl 2 hrs after meal

After-Meal Goals for Children: 

After-Meal Goals for Children Under 5 Years: <250 @ 1 hr. post-meal (<120 pt. Rise) 5-11 Years: <225 @ 1 hr. post-meal (<100 pt. Rise) 12 Years + < 200 @ 1 hr. post-meal (<80 pt. Rise)

After-Meal Peaks: Reality for children: 

After-Meal Peaks: Reality for children Source: Boland et al, Diabetes Care 24: 1858, 2001

After-Meal Peaks: Reality in Children: 

After-Meal Peaks: Reality in Children Source: Boland et al, Diabetes Care 24: 1858, 2001

After-Meal Highs: Immediate Problems: 

After-Meal Highs:Immediate Problems Tiredness Difficulty Concentrating Impaired Athletic Performance Decreased desire to move Mood Shifts Enhanced Hunger

Long-Term Problems: 

Long-Term Problems Percent Contribution to HbA1c Source: Monnier et al, Diabetes Care, 26, 3/03, 881-885

Long-Term Problems (contd): 

Long-Term Problems (contd) 52 Type 1’s, similar BP between groups Source: Kidney Intl. 1987; 32 (supp 22): S53-S56

Long-Term Problems (contd): 

Long-Term Problems (contd) 22-yr CVD Mortality Risk by Baseline post-challenge glucose Source: Chicago Heart Study, Lowe et al, Diabetes Care, 1997; 20: 163-170.

Measurement of After-Meal Peaks: 

Measurement of After-Meal Peaks SMBG Capillary (finger) test After completion of meal Check BG 1 Hr PP (or) every 15, 20 or 30 min until 2 consecutive BG drops occur No addl. Food/insulin until test is completed

Meter Test Example: 

Meter Test Example Interpretation: Excessive after-meal peak following breakfast; not after lunch or dinner

Meter Test Example: 

Meter Test Example Time pp BG Value Premeal 135 :20 155 :40 168 1:00 214 1:20 222 1:40 175 2:00 141 Interpretation: Peak occurred at 1hr, 20min pp; rise from premeal to peak was approx. 90 mg/dl

Measurement of After-Meal Peaks: 

Measurement of After-Meal Peaks Glucowatch (Cygnus/Animas) Takes readings every 10 minutes, following 2-hr warmup Can download to computer or retrieve readings manually May “skip” readings during periods of rapid rise or fall

Measurement of After-Meal Peaks: 

Measurement of After-Meal Peaks CGMS (Medtronic) Worn for 72 hrs (or more), then data is downloaded Meals should be entered as “events” while wearing Calculates 3-hr post-meal averages

CGMS Case Study: 

CGMS Case Study 37 year old man

CGMS Case Study: 

CGMS Case Study 8 year old girl

CGMS Case Studies: 

CGMS Case Studies 12 year old boy

After-Meal Spike Reduction: 

After-Meal Spike Reduction Lifestyle Approaches Medicinal Approaches

Dietary Intervention: 

Dietary Intervention Use of Glycemic Index Lower GI foods digest & convert to glucose more slowly High-fiber slower than low Hi-fat slower than low Solids slower than liquids Cold foods slower than hot Type of sugar/starch affects GI

Use of Glycemic Index (contd): 

Use of Glycemic Index (contd)

Examples: Use of GI: 

Examples: Use of GI  

Choice of Bolus Insulin: 

Choice of Bolus Insulin

Choice of Bolus Insulin: 

Choice of Bolus Insulin

Timing of Bolus Insulin: 

Timing of Bolus Insulin

Timing of Bolus Insulin: 

Timing of Bolus Insulin (humalog/novolog)

Does Timing Matter?: 

Does Timing Matter? Bolus w/meal Bolus pre-meal

Choice of Insulin Program: 

Choice of Insulin Program

Injectible Symlin (Amylin Pharmaceuticals) : 

Injectible Symlin(Amylin Pharmaceuticals) Acts on CNS  Appetite Slows gastric emptying Inhibits glucagon secretion Really flattens postprandial BGs

Injectible Symlin (Amylin Pharmaceuticals) : 

Injectible Symlin(Amylin Pharmaceuticals) Issues Nausea Must be injected*, cannot mix w/insulin Insulin doses must be adjusted, delayed Not yet FDA approved for children * pumped???

Physical Activity Intervention: 

Physical Activity Intervention Muscle Use Soon After Eating Accelerated Delayed Glucose Uptake/ Insulin Absorption Digestion Utilization Improved After-Meal Control

Examples: After-Meal/Snack Activity: 

Examples: After-Meal/Snack Activity Walking Pets Household Chores Planned Exercise Yard Work Gym Class??? Shooting Hoops Dancing Bowling Mini Golf Skating

Examples: After-Meal/Snack Activity: 

Examples: After-Meal/Snack Activity “Free Time With Siblings”

Summary : 

Summary After-Meal Blood Sugar Levels Are: Important to Control Measurable Manageable

For More Information:: 

For More Information: Gary Scheiner MS, CDE Integrated Diabetes Services 877-735-3648 (877-SELF-MGT) Website: www.integrateddiabetes.com E-mail: garyscheiner@prodigy.net