Slide2: Ritesh Mistry, PhD Antronette Yancey, MD, MPH UCLA School of Public Health Jonsson Comprehensive Cancer Center Division of Cancer Prevention and Control Research Friday, September 9, 2005


Slide3: Roshan Bastani, PhD Principal Investigator Antronette Yancey, MD, MPH Co-Principal Investigator Annette Maxwell, DrPH Co-Principal Investigator Co-Investigators Joyce Jones Guinyard, DC Barbara Berman, PhD Beth Glenn, PhD William McCarthy, PhD Leo Morales, MD, PhD Paul Simon, MD, MPH Cynthia Harding, MPH Weng Kee Wong, PhD Director Ritesh Mistry, PhD, MPH 2004-2009


Slide4: Marjorie Kagawa-Singer, PhD, MN, RN Principal Investigator Roshan Bastani, PhD Co-Principal Investigator Annette Maxwell, DrPH Co-Investigator Angela Jo, MD Co-Investigator Paul Murata, MD, MSPH Co-Investigator 2000-2005 2005-2010


Cancer Prevention and Control Research Network Sites Funded by: CDC & NCI-2004-2009: Cancer Prevention and Control Research Network Sites Funded by: CDC & NCI-2004-2009


Introducing CORICA to Los Angeles : Introducing CORICA to Los Angeles Over 10 million people live in LA county, with 88 cities in an area of 4,000 miles


Challenges & Opportunities in Los Angeles : Challenges & Opportunities in Los Angeles LA: one of the most diverse areas in the world 47% Latino 30% White 12% Asian 9% African America 2% More than one ethnicity 1% Other


Challenges & Opportunities in Los Angeles : Challenges & Opportunities in Los Angeles


Slide9: Leading Cause of Deaths USA


Slide10: Leading Causes of Cancer Deaths


Causes of Cancer Disparities: Causes of Cancer Disparities Probably not genetic Nutrition & Physical Activity Tobacco use Viruses (Hepatitis B, HPV) Lack of early-detection Lack of timely and aggressive treatment


Obesity and risk of common cancers: Women Endometrial, ovarian, colon, breast (post-menopausal), renal cell Men Colon, prostate Possible Mechanisms: Hyperinsulinemia (especially central adiposity) associated with cell growth & proliferation Adipose tissue is primary source of estrogens, which has been linked to carcinogenesis Obesity and risk of common cancers


Dietary components and risk of common cancers: Dietary components and risk of common cancers


Physical Activity and risk of common cancers: Physical Activity and risk of common cancers Possible mechanisms: 1. Decreased GI transit time which decreases carcinogen exposure) 2. Enhanced immune function with moderate PA 3. Lowered levels of reproductive hormones


AIM Reduce cancer disparities in our diverse populations: AIM Reduce cancer disparities in our diverse populations Strengthen ties between academic public health practice setting: California Department of Health Services Los Angeles County Department of Health Services, esp. Public Health Community-based organizations


CORICA AIMS: CORICA AIMS Conduct & evaluate community based programs to prevent and control cancer, with focus on: Obesity, Nutrition and Physical Activity Cancer Screening Tobacco


Slide17: CORICA Community Activities Awareness and education activities Annual symposia Training events Newsletters and reports Involve organizations serving diverse populations Community Investigative Team Community-university collaborative research projects Community activities, e.g., Hepatitis B screening campaign, community needs assessment, organizational capacity assessment and capacity-building


Slide18: CORICA Community Activities Mini-grants to community-based organizations (CBOs) for cancer prevention and control activities Interns placed in CBOs Provide technical support for research activities such as: analyze data on CBO-initiated programs co-authoring scientific publications, e.g., journal articles, legislative policy briefs


Slide19: CORICA Community Activities Year 01 Successes: 1st symposium attracted: Over a 150 representatives from more than 50 organizations Several grants submitted including: A Research Partnership with LAC DHS: Joining forces with a key community to reduce obesity”


Slide20: CORICA Community Activities Year 01 Successes, continued: Collaborating on journal articles with int’l gov’t, local gov’t, and CBOs: Pausa para tu salud Adelante con leche descramada Overweight self-perception and sedentariness ethnic & gender variations


Slide21: Adelante con leche descramada: A Campaign to increase consumption of low-fat milk


Slide22: Weight self-perception in Los Angeles Adults BMI


Community-Based Cancer Prevention and Control Programs are Critical: Community-Based Cancer Prevention and Control Programs are Critical Important to only implement programs that work How do you know if a program is effective? RESEARCH


Challenges & Opportunities in Los Angeles: Challenges & Opportunities in Los Angeles Presence of institutions and people with commitment to reduce the burden of cancer University Community