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Research Opportunities at the National Institute of Mental Health: 

May 3, 2006 Research Opportunities at the National Institute of Mental Health

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Reduce the burden of mental illness and behavioral disorders through research on mind, brain and behavior NIMH Mission

Slide3: 

Mental disorders are arguably the largest source of morbidity and mortality for young people in the U.S. These disorders may be the costliest in terms of direct and indirect care.

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WHO World Health Report 2002 Mental Disorders are the Largest Source of Disability from Medical Causes United States and Canada 15-44 years old

Discovery to Recovery: Translation is the Key: 

Discovery to Recovery: Translation is the Key Bench Bedside Pathophysiology Diagnostic tests Biomarkers New treatments

NIMH Organization: 

NIMH Organization Basic Translational Research - adult Trials & Services Translational Research - child Health & Behavior

NIMH Budget (dollars in millions): 

NIMH Budget (dollars in millions) 21-Feb-06 n:\budget\2007\graphs\

How do we set priorities?: 

How do we set priorities? Relevance – what do we need? Traction – where are the opportunities? Innovation – what is new? Relevance + Traction + Innovation = IMPACT

Division of Neuroscience and Basic Behavioral Science (DNBBS): 

Division of Neuroscience and Basic Behavioral Science (DNBBS) Supports research and training in the areas of basic neuroscience, genetics, basic behavioral science, research training, resource development, technology development, drug discovery, and research dissemination.

High Priorities for DNBBS: 

High Priorities for DNBBS Hormone-induced Changes Develop neurobiological models and tools to understand hormone-induced changes in mood and cognition during life transitional periods. Complex Social Behavior Elucidate fundamental mechanisms of complex social behavior. Vertebrate-Invertebrate Models Develop vertebrate and invertebrate models to understand the biological functions of genes, gene products, cellular functions, networked circuits, and systems implicated in mental disorders.

High Priorities for DNBBS (continued): 

High Priorities for DNBBS (continued) Genes Identify in ethnically diverse populations from the US and around the world genetic variants, epigenetic mechanisms, and gene-environment interactions that influence vulnerability to mental disorders, endophenotypes, and pharmacologic response profiles.. Hippocampus Identify the role of the hippocampus and related circuits in the etiologies of disorders of mood and cognition through studies of hippocampal development and function at the molecular, cellular, neural and behavioral levels. Biomarkers Identify biological markers in model systems and humans that could be further validated as methods for diagnosing and/or detecting risk/vulnerability, onset, progress, and/or severity of mental disorders.

Division of Adult Translational Research and Treatment Development (DATR): 

Division of Adult Translational Research and Treatment Development (DATR) Supports research and training aimed at understanding the pathophysiology of mental illness and hastening the translation of behavioral science and neuroscience advances into innovations in clinical care.

High Priorities for DATR: 

High Priorities for DATR Neural Circuits Delineate specific neural circuits contributing to one or more mental major mental disorders or subtypes of mental disorders. Biomarkers Develop, test, and validate biological markers for diagnosing or detecting risk/vulnerability, onset, progress, and/or severity of adult mental disorders. Models to Predict Treatment Response Develop models to predict treatment response and vulnerability to side effects of psychotropic medications and approaches to prevent or ameliorate treatment-emergent side effects.

High Priorities for DATR (continued): 

High Priorities for DATR (continued) Vulnerability Mechanisms & Early Interventions Identify mechanisms (e.g., genetic, biological, behavioral, environmental) that confer vulnerability to psychiatric illnesses and develop early interventions (pharmacological and/or psychosocial) for reducing the severity and incidence of psychopathology. Novel Interventions Evaluate the safety and efficacy of novel mechanism pharmacological agents and/or behavioral interventions that target domains of psychopathology inadequately addressed by current therapies or prevention strategies. Clinical Trials Methodology Develop, test, and validate methods to assess domains of psychopathology for use in clinical trials in order to increase the efficiency of the mental illness treatment development critical path, emphasizing approaches based on partnerships with the FDA and industry.

Division of Pediatric Translational Research and Treatment Development (DPTR): 

Supports research and training with the ultimate goal of preventing and curing childhood psychopathology. Stimulates and promotes an integrated program of research across basic behavioral/ psychological processes, environmental processes, brain development, pediatric psychopathology and therapeutic interventions. Division of Pediatric Translational Research and Treatment Development (DPTR)

High Priorities for DPTR: 

High Priorities for DPTR Neurobehavioral Development Delineate mechanisms and processes of neurobehavioral development relevant to understanding pediatric mental disorders with a focus on periods of rapid neurobiological change. Gender Differences Identify psychosocial and neurobiological mechanisms underlying sex differences in, and gender influences on, pediatric mental disorders. Biomarkers Develop, test, and validate biologically based markers for diagnosing or detecting risk/vulnerability, onset, progress, and/or severity of pediatric mental disorders.

High Priorities for DPTR (continued): 

High Priorities for DPTR (continued) Characterization Improve the phenotypic characterization of pediatric mental disorders and refine standardized behavioral assessment tools that are sensitive to developmental change, cultural diversity, and variation in functioning. Risk or Protections Identify mechanisms and processes that confer risk for or protection from childhood psychopathology. Novel Treatments Develop novel therapies for serious mental disorders of childhood and adolescence.

Division of AIDS and Health and Behavior Research (DAHBR): 

Division of AIDS and Health and Behavior Research (DAHBR) Supports research and training to: Develop and disseminate behavioral interventions that prevent HIV/AIDS transmission. Clarify the pathophysiology and alleviate the neuropsychiatric consequences of HIV/AIDS infection. Use a public health model to reduce the burden of mental illness from medical comorbidities, non-adherence to treatment, societal stigma, health disparities and unhealthy behaviors.

High Priorities for DAHBR: 

High Priorities for DAHBR Health Behaviors Identify basic behavioral processes that determine health behaviors among people with mental disorders in order to develop interventions to improve functional outcomes and reduce morbidity and mortality. Stigma and Discrimination Identify the basic behavioral and social processes in stigma and discrimination associated with mental illness and develop effective programs and approaches to reduce or even eliminate stigma. HIV Prevention Support innovative, interdisciplinary HIV prevention research designed to better understand individual, dyadic, community, social, and structural factors that impact HIV risk-reduction in order to improve sustained preventive behaviors.

High Priorities for DAHBR (continued): 

High Priorities for DAHBR (continued) Technology Transfer of Prevention Interventions Conduct research on expeditious technology transfer of preventive interventions for HIV-positive persons in treatment and other settings, with a focus on diffusion, translation, effectiveness and operational research in order to bridge research and practice. NeuroAIDS Support studies to assess the neurologic, neuropsychiatric, and neuropathologic consequences of HIV in the current therapeutic context, particularly in international and resource-poor settings, in order to develop new therapeutic interventions to prevent or reverse these complications. Children Affected by AIDS Support innovative, interdisciplinary prevention science research designed to better understand the psychosocial needs of children affected by AIDS, particularly in low-resource settings.

Division of Services and Intervention Research (DSIR): 

Division of Services and Intervention Research (DSIR) DSIR supports two critical areas of research and training: Mental health services research Intervention research to evaluate the effectiveness of pharmacologic, psychosocial, somatic, rehabilitative and combination interventions on mental and behavior disorders for children, adolescents, and adults.

High Priorities for DSIR: 

High Priorities for DSIR Side Effects and Adverse Events Identify side-effects and adverse events from interventions used in current practice across diverse settings and populations of all ages to improve effective, personalized treatment and prevention strategies to optimize outcomes. Effectiveness Test the effectiveness of interventions in community and practice settings, with special emphases on ‘practical’ trials and assessment of multiple outcomes. Suicidality Improve the detection, assessment, interventions, and services for suicidality in populations of all ages.

High Priorities for DSIR (continued): 

High Priorities for DSIR (continued) Co-occurrence Test the effectiveness of treatments and services for people with co-occurring mental, substance use, and/or physical health problems. Dissemination and Implementation Pinpoint effective dissemination and implementation processes and mechanisms to increase the uptake of scientifically informed treatments and services for mental disorders across all settings and populations. Research Capacity and Infrastructure Enhance the research capacity and infrastructure to conduct research in diverse mental health service settings through strategic partnerships, community engagement/participation, information technologies, and development of new and innovative methods for designing and conducting effectiveness and services research.

National Institutes of Health FY 2004 Research Training & Career Funds (Fs, Ts & Ks) As a Percent of IC Awards Budget (incl. AIDS): 

National Institutes of Health FY 2004 Research Training & Career Funds (Fs, Ts & Ks) As a Percent of IC Awards Budget (incl. AIDS) NIH Average

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www.nimh.nih.gov

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