transforming growth factor beta

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transforming growth factor beta

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Transforming growth factor beta by Creative BioMart

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The transforming growth facor beta ( TGF-β ) superfamily is a large family of growth factors named after the first member TGF-β1. Members of TGF-β superfamily are similar in structure. TGF-β superfamily distributes in invertebrates as well as vertebrates species.

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They play role in dorso-ventral patterning, mesoderm induction and patterning, and also in limb bud formation, bone and cartilage formation, neuron differentiation. So TGF-β superfamily is important in development of a variety of different tissues and organs.

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The transforming growth factor-β (TGF-β) superfamily is a family of proteins that is involved in regulating and mediating processes at the cellular level, including cell proliferation, differentiation, motility, adhesion and apoptosis, as well as processes at the tissue and organism level, including development, wound healing, fibrosis and angiogenesis. The TGF-β superfamily consists of ligands and receptors that all signal, at least in part, through well characterized downstream mediators termed the Smads.

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TGF beta related literatures 1. Herpin A, Lelong C, Favrel P. Transforming growth factor-β-related proteins: an ancestral and widespread superfamily of cytokines in metazoans[J]. Developmental & Comparative Immunology, 2004, 28(5): 461-485. 2. Massagué J. TGF-β signal transduction[J]. Annual review of biochemistry, 1998, 67(1): 753-791. 3. Gordon K J, Blobe G C. Role of transforming growth factor-β superfamily signaling pathways in human disease[J]. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 2008, 1782(4): 197-228. 4. Dong M, How T, Kirkbride K C, et al. The type III TGF-β receptor suppresses breast cancer progression[J]. Journal of Clinical Investigation, 2007, 117(1): 206.

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