Schistosoma japonicum flores

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Schistosoma japonicum :

Schistosoma japonicum

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Schistosoma japonicum is an important parasite and one of the major infectious agents of schistosomiasis .This parasite has a very wide host range, infecting at least 31 species of wild mammals, including 9 carnivores , 16 rodents , one primate (Human), two insectivores and three artiodactyls and therefore it can be considered a true zoonosis .

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Schistosoma japonicum is digenic trematode (" digenic " means that its lifecycle includes two hosts - definitive and intermediate) of the superfamilySchistosomatoidea .

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Intermediate host of S. japonicum are snails of the genus Onchomelania hupensis spp. S. japonicum occurs in Southeast Asia and western Pacific countries (including China, the Philipines and Indonesia).

Disease :

Disease Schistosoma japonicum is the only human blood fluke that occurs in China. It is the cause of schistosomiasis japonica, a disease that still remains a significant health problem especially in lake and marshland regions. Schistosomiasis is an infection caused mainly by three schistosome species; Schistosoma mansoni , Schistosoma japonicum and Schistosoma haematobium .

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S. japonicum being the most infectious of the three species. Infection by schistosomes is followed by an acute Katayama fever. The disease was named after an area it was endemic to, Katayama district, Hiroshima, Japan. If left untreated, it will develop into a chronic condition characterized by hepatosplenic disease and impaired physical and cognitive development. The severity of S. japonicum arises in 60% of all neurological diseases in schistosomes due to the migration of schistosome eggs to the brain.

Morphology :

Morphology The S. japonicum worms are yellow or yellow-brown. The males of this species are slightly larger than the other Schistosomes and they measure ~ 1.2 cm by 0.5 mm. The females measure 2 cm by 0.4 mm. The adult worms are longer and narrower than the related S. mansoni worms. By electron microscopy there are no bosses or spines on the dorsal surface of the male, which is ridged and presents a spongy appearance. Many spines cover the inner surface of the oral sucker and extend to the pharyngeal opening. The oral sucker shows a rim with spines of variable size and sharpness inward and outward from the rim. The ventral sucker possesses many spines which are smaller than in the oral sucker. The lining of the gynecophoric canal is roughened by minute spines. The integument of the female is ridged and pitted and possesses fewer spines than in the oral sucker, the ventral sucker, and the gynecophoric

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canal of the male. Anterior to the acetabulum , the integumental surfaces are devoid of spines. However, in the other areas, spines are equally distributed except for the vicinity of the excretory pore. The ova are about 55 - 85 μm by 40 - 60 μm , oval with a minute lateral spine or knob.

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Pathology Once the parasite has entered the body and begun to produce eggs, it uses the host’s immune system ( granulomas ) for transportation of eggs into the gut. The eggs stimulate formation of granuloma around them. The granulomas , consisting of motile cells, carry the eggs to the intestinal lumen.

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When in the lumen,granuloma cells disperse leaving the eggs to be excreted within feces. Unfortunately, about two-thirds of eggs are not excreted, instead they build up in the gut. This can lead to fibrosis in chronic cases. S. japonicum is the most pathogenic of the schistosoma species because it produces up to 3,000 eggs per day, ten times greater than that of S. mansoni . .

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As a chronic disease, S. japonicum can lead to Katayama fever, liver fibrosis, liver cirrhosis, liver portal hypertension, splenomegaly , and ascites . Some eggs may pass the liver and enter lungs, nervous system and other organs where they can adversely affect the health infected individual.

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Diagnosis Histopathological image of old state of schistosomiasis incidentally found at autopsy. The deposition of calcified eggs in the colonic submucosa suggests prior infection of Schistosoma japonicum . Microscopic identification of eggs in stool or urine is the most practical method for diagnosis. Stool examination should be performed when infection with S.mansoni or S. japonicum is suspected, and urine examination should be performed if S. haematobium is suspected.

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Eggs can be present in the stool in infections with all Schistosoma species. The examination can be performed on a simple smear (1 to 2 mg of fecal material). Since eggs may be passed intermittently or in small amounts, their detection will be enhanced by repeated examinations and/or concentration procedures (such as the formalin - ethyl acetate technique).

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. In addition, for field surveys and investigational purposes, the egg output can be quantified by using the Kato-Katz technique (20 to 50 mg of fecal material) or the Ritchie technique. Eggs can be found in the urine in infections with S. haematobium (recommended time for collection: between noon and 3 PM) and with S. japonicum . Detection will be enhanced by centrifugation and examination of the sediment.

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Quantification is possible by using filtration through a Nucleopore membrane of a standard volume of urine followed by egg counts on the membrane. Tissue biopsy (rectal biopsy for all species and biopsy of the bladder for S. haematobium ) may demonstrate eggs when stool or urine examinations are negative.

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Quantification is possible by using filtration through a Nucleopore membrane of a standard volume of urine followed by egg counts on the membrane. Tissue biopsy (rectal biopsy for all species and biopsy of the bladder for S. haematobium ) may demonstrate eggs when stool or urine examinations are negative.

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past two years. Ultrasonographic examination can be performed to assess the extent of hepatic and spleen-related morbidity . The problems with immunodiagnostic methods are that 1) It is only positive a certain time after infection 2) They can cross interact with other helminthes infections.

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Treatment The chemotherapy of choice is praziquantel , a quinolone derivative. Praziquantel is generally administered in an oral form in one or two doses from 40–60 mg/kg body weight.Combination treatment may prevent morbidity due to schistosomiasis . Praziquantel is most active against adult worms.

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However, it has been found that artemether prevents the development of adult worms, thus decreasing egg production in the host. If both praziquantel and artemether can be used together, the entire lifespan of S. japonicum would be covered in the vertebrate host.

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Prevention Human waste should be hygienically disposed of. Human waste in water with the Oncomelania snail intermediate host is a major cause to the perpetuation of schistosomiasis . To prevent this from occurring, human waste should never be used for nightsoiling (fertilization of crops with human waste) and unsanitary conditions should be improved.

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Treatment The chemotherapy of choice is praziquantel , a quinolone derivative. Praziquantel is generally administered in an oral form in one or two doses from 40–60 mg/kg body weight.Combination treatment may prevent morbidity due to schistosomiasis . Praziquantel is most active against adult worms. However, it has been found that artemether prevents the development of adult worms, thus decreasing egg production in the host.

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If both praziquantel and artemether can be used together, the entire lifespan of S. japonicum would be covered in the vertebrate host.

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Barrier cream with a dimethicone base offered high levels of protection for at least 48 hours.The search for a practical vaccine continues and could greatly benefit affected areas

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Control Control against infection of S. japonicum requires multiple efforts consisting of education, eliminating the disease from infected individuals, controlling the vector, and providing a protective vaccine.

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Social Impacts Individuals at risk to infection from S. japonicum are farmers who often wade in their irrigation water, fisherman that wade in streams and lakes, children that play in water, and people who wash clothes in streams

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Taxonomic lineage cellular organisms - Eukaryota - Fungi/ Metazoa group - Metazoa - Eumetazoa - Bilateria - Acoelomata - Platyhelminthes - Trematoda - Digenea - Strigeidida - Schistosomatoidea - Schistosomatidae - Schistosoma - Schistosoma japonicum

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Life cycle The life cycles of Schistosoma japonicum and Schistosoma mansoni are very similar. In brief, eggs of the parasite are released in the feces and if they come in contact with water they hatch into free-swimming larva, called miracidia .

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The larva then has to infect a snail of the genus Oncomelania such as species of Oncomelania hupensis within one or two days. Inside the snail, the larva undergo asexual reproduction through a series of stages called sporocysts . After the asexual reproduction stage cercaria (another free-swimming larva) are generated in large quantities, which then leave (shed into the environment) the snail and must infect a suitable vertebrate host.

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the host it loses its tail and becomes a schistosomule . The worms then migrate through the circulation ending at the mesenteric veins where they mate and start laying eggs. Each pair desposits around 1500 – 3500 eggs per day in the vessels of the intestinal wall. The eggs infiltrate through the tissues and are passed in the feces.

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