ASTHMA ALLAT APOINT CURREBT STUDIES BY BADRI

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1 A PROJECT REPOPRT SUBMITTED BY MET’S INSTITUTE OF PHARMACY, ADGAON (NASHIK)

INTRODUCTION TO ASTHMA: 

2 INTRODUCTION TO ASTHMA Asthma is a chronic inflammatory disorder of the airways in which many cells & cellular elements play a role (mast cells, eosinophils, T lymphocytes, macrophages, neutrophils, & epithelial cells). In susceptible individuals , inflammation causes recurrent episodes of wheezing, breathlessness, chest tightness, and coughing, particularly at night/early morning. These episodes are associated with variable airflow obstruction often reversible spontaneously/treatment

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3 DIFFERENCE BETWEEN NORMAL AND ASTHMATIC PERSON Airways narrow, caused by: tightening of the muscles that surround the airways swelling of the inner lining, and/or increase in mucus production

CAUSES: 

CAUSES 4 ENVIRONMENTAL GENETIC B2AR is located on chromosome 5q GENE-ENVIRONMENT INTERACTIONS CD14-ENDOTOXIN REACTIONS ALLERGENS POLLUTION

Pathophysiology : 

Pathophysiology 5 Inflammation Bronchial smooth muscle Hypertrophy + Mucous glands Hypertrophy Thick mucous Plugging of small airway (bronchoconstriction) Hyper responsiveness to triggers Long period (chronicity)

PATHOPHYSIOLOGY: 

PATHOPHYSIOLOGY

TRICKS TO COUNTER ASTHMA-: 

TRICKS TO COUNTER ASTHMA- 7

DRUGS USED FOR TREATMENT: 

DRUGS USED FOR TREATMENT 8

CONTROLLERS: 

9 CONTROLLERS Inhaled glucocorticoid Long-acting inhaled b2-agonists Leukotriene modifiers Theophylline Cromones Anti-IgE Systemic glucocorticoids

RELIEVERS: 

10 RELIEVERS

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11 Asthma is a problem worldwide, with an estimated 300 million affected individuals Prevalence increasing in many countries, especially in children A cause of a significant number of preventable deaths A major cause of school/work absence EPIDEMIOLOGY

FUTURE SCOPE: 

FUTURE SCOPE 12 SO WE SHOULD HOPE FOR A BETTER SCOPE

THANK YOU !!: 

THANK YOU !!

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