Presentation Transcript
Slide1: 1 A PROJECT REPOPRT SUBMITTED BY
MET’S INSTITUTE OF PHARMACY, ADGAON (NASHIK)
INTRODUCTION TO ASTHMA: 2 INTRODUCTION TO ASTHMA Asthma is a chronic inflammatory disorder of the airways in which many cells & cellular elements play a role (mast cells, eosinophils, T lymphocytes, macrophages, neutrophils, & epithelial cells). In susceptible individuals , inflammation causes recurrent episodes of wheezing, breathlessness, chest tightness, and coughing, particularly at night/early morning. These episodes are associated with variable airflow obstruction often reversible spontaneously/treatment
Slide3: 3 DIFFERENCE BETWEEN NORMAL AND ASTHMATIC PERSON Airways narrow, caused by:
tightening of the muscles that surround the airways
swelling of the inner lining, and/or
increase in mucus production
CAUSES: CAUSES 4 ENVIRONMENTAL
GENETIC B2AR is located on chromosome 5q
GENE-ENVIRONMENT INTERACTIONS CD14-ENDOTOXIN REACTIONS ALLERGENS POLLUTION
Pathophysiology : Pathophysiology 5 Inflammation Bronchial smooth muscle
Hypertrophy +
Mucous glands
Hypertrophy Thick mucous Plugging of small airway
(bronchoconstriction) Hyper responsiveness to triggers Long period (chronicity)
PATHOPHYSIOLOGY: PATHOPHYSIOLOGY
TRICKS TO COUNTER ASTHMA-: TRICKS TO COUNTER ASTHMA- 7
DRUGS USED FOR TREATMENT: DRUGS USED FOR TREATMENT 8
CONTROLLERS: 9 CONTROLLERS Inhaled glucocorticoid
Long-acting inhaled b2-agonists
Leukotriene modifiers
Theophylline
Cromones
Anti-IgE
Systemic glucocorticoids
RELIEVERS : 10 RELIEVERS
Slide11: 11 Asthma is a problem worldwide, with an estimated 300 million affected individuals
Prevalence increasing in many countries, especially in children
A cause of a significant number of preventable deaths
A major cause of school/work absence EPIDEMIOLOGY
FUTURE SCOPE: FUTURE SCOPE 12 SO WE SHOULD HOPE FOR A BETTER SCOPE
THANK YOU !!: THANK YOU !!
Slide14: 14