SmartHEALTH Bucharest 230307

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Project Dissemination: Alan Greatbatch The NEXUS Association, Switzerland Smart Integrated Biodiagnostic Systems for Healthcare Nexus-Minos Brokerage Event Bucharest 230307

SmartHEALTHIntegrated Project: 

SmartHEALTH Integrated Project SmartHEALTH Aim: to develop innovative Point-of-Care (PoC) test systems for biomarker determination. To apply these to all areas of healthcare management, patient management and information systems i.e. addressing the “real” cost per test. Healthcare costs can be reduced by moving from a system with high complexity, located in a highly technical area requiring medical support, to a system with low complexity, in a low technical area not requiring immediate medical support. FP6-2004-IST-NMP-2: Bio-sensors for Diagnosis and Healthcare

SmartHEALTH Consortium: 

SmartHEALTH Consortium 26 partners, including 4 Universities, 7 Research Institutions, 10 SMEs, 2 larger Companies and 4 Clinical Groups Partners come from 10 EU states, Norway, Switzerland and Australia. Clinical Partners Newcastle Hospitals NHS Foundation Trust University Hospital of Jena BIOEF Charité Exploitation/Dissemination Partners WTC MiniFAB DCU (NCSR) iXscient The NEXUS Association Societal Issues UNEW (Ethics) UNITN (Gender) Bioassay Developers CanAg Gaiker TATAA Biocentre FZK University Hospital of Jena Technology Component Suppliers UNEW MiniFAB Microfluidic ChipShop IMM Zarlink Fraunhofer-IBMT TNO Ikerlan IMEC ETSE URV CSEM FZK TATAA Biocentre Telecom Italia System Integrators Olivetti I-Jet IMM CSEM

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Clinical validation and integration into healthcare systems Base station / portable unit integrating access, processing, control, sensor analysis, data analysis, user displays and interface, communications. Biometric access, smartcard interface Disposable fluidic cartridge with integrated biosensors (contaminated with patient sample) Communications access, utilising best local facilities available Ambient environment including electronic patient records, hospital and laboratory information systems, users home PCs, and on-line interface. Smart Bio-Diagnostics for Healthcare

SmartHEALTH Objectives: 

SmartHEALTH objectives include: Introduce new SmartHEALTH sensor systems into future healthcare services to improve and better existing services. Demonstrate the role of Ambient Intelligent (AmI) medical devices and online services for pervasive healthcare provision. Demonstrate clinical validation of systems for targeted applications in breast, cervical and colorectal cancer. Demonstrate the economic benefits and means of healthcare provision for the targeted clinical applications. Develop new manufacturing technologies for realization of unique sensor solutions integrating fluidics, transducers and biological assays. SmartHEALTH Objectives

Diagnostics are Changing: 

Diagnostics are Changing Diagnosis Monitoring Risk prediction – what could happen? Early detection – what is happening now? Therapy prediction – what will happen? Pharmacogenomics – which therapy to use? test drug test TODAY TOMORROW test test test test test/drug test Expand Testing Market Traditional Diagnostics Provide Health Information: Disease risk Drug Choice Health Status Therapy Efficacy Increasing role in management decisions Prognosis

Clinical Applications and Site of Testing: 

Clinical Applications and Site of Testing Relationship between clinical applications, technical and medical complexity of diagnostic device and biodiagnostic locale. WP1b Cervical cancer diagnosis: Analyses of DNA/RNA and proteins in cells. WP 1c Theranostics/prognostics in colon cancer. . : Analyses of DNA/RNA and proteins in tissue samples. Central Laboratory Speciality Laboratory Bedside/ Clinic in Supported Environment e.g. Hospital Dept. GP or Clinic Less supported environment Ambulatory ward Portable device Minimal support Consumer Home testing instrument only Simple High Technical & Medical support High complexity Low Technical & Medical support Low complexity WP1a Breast cancer follow up and monitoring. Analyses of proteins in body fluids. WP1a Breast cancer follow up and monitoring. Analyses of proteins in body fluids.

SmartHEALTH Development Path: 

SmartHEALTH Development Path

Acknowledgements: 

Acknowledgements European Commission (IST-NMP-2-016817) SmartHEALTH Web Page: www.smarthealthip.com