logging in or signing up Спирива Arkhipov Download Post to : URL : Related Presentations : Share Add to Flag Embed Email Send to Blogs and Networks Add to Channel Uploaded from authorPOINT lite Insert YouTube videos in PowerPont slides with aS Desktop Copy embed code: (To copy code, click on the text box) Embed: URL: Thumbnail: WordPress Embed Customize Embed The presentation is successfully added In Your Favorites. Views: 166 Category: Entertainment License: All Rights Reserved Like it (0) Dislike it (0) Added: June 15, 2009 This Presentation is Public Favorites: 0 Presentation Description No description available. Comments Posting comment... Premium member Presentation Transcript ??????????? ???????????? ??????????????????? ?????????? : ??????????? ???????????? ??????????????????? ?????????? Slide 2: M-ACh R M-ACh R a,ß-Adr R ???????????? ????? ????????????? ????? ???????????????? ?????, eg. n. vagus Slide 3: H-ACh R M1 a,ß-Adr R ???????????? ????? ????????????? ????? ???????????????? ?????, eg. n. vagus M2 M3 ????????? ?1 ? ?3 ?????????????????. ??? ?????? ??? ???????? ???????. ????????? M2 – ????????????????. ??? ???????? ???????? ???????. ??????????? – ???????? ???????? ????????????????? ??????? ??????? : Na+ ????? Ca++ M3 ????????????? ?????????????? ? ??????????? M2 ??????????? – ???????? ???????? ????????????????? ??????? ??????? ??????? ????????????????? ?????????? : ??????? ????????????????? ?????????? ?????? (M2): ????, ?????????????, ? ????????????. ??????: ????????????? ??????? ???????????: ????, ??????????? ?????????? ?? ??????? ??????. ???: ? ?????? ?????????, ? ?????? ??????????. ??????: ? ?????? ???????, ? ???????? ???????????? ?????. ??????????? ??????: ? ?????????, ??????????? ????????. ?-???????????? : ?-???????????? ??????????? ?????????? ???????? ??????? ???????? Slide 7: ???????????????? ???????? ????????????? ???????? ?????????????? ? ??????????????? ????????????????????? ?????????? ??????????? ????????? ?? ? ???? ?????????? ?????????? ?????????? ??????? ???? ????????? ?????? ????????? ? ???????? ????? ??????? ???? ???????????? ?????????? ???????? ?????????? ??????? ???? ???????? ????????: ????????????????? ???????: ???????? ?????? ??????? : ???????? ?????? ??????? ???????????? ??????? ??????? ?????????????: a-AR (???????????), ß-AR (?????????) ?????????????????: ?-??????????????? (???????????) ????????? ?????????? (????????, ???????????, ????????) ?????????????: NO ???????????????? ?????????? ? - ???????????????? : ???????????????? ?????????? ? - ???????????????? ??????? ????????????? : ??????? ????????????? Disse B et al. Life Sci 1999; 64:457-464 ???????????????? ???????? ???????????? ? ??????????? : ???????????????? ???????? ???????????? ? ??????????? van Noord JA et al. Thorax 2000; 55: 289-94 ???1 (?) ???? ????? ????????? 1.5 1.6 1.1 1.3 1.2 1.4 ???? ????? ????????? 1.5 1.6 1.1 1.3 1.2 1.4 92-? ???? 1-? ???? 0 5 -1 1 2 3 4 6 0 5 -1 1 2 3 4 6 ?????????? ??????????? ???1 (?) ???????? ?-????????????? ?? ?????????? ? ???????? ??????? : ???????? ?-????????????? ?? ?????????? ? ???????? ??????? COMBIVENT Inhalation Aerosol Study Group. Chest 1994; 105:1411-19 ???????? ???????? ????? : ???????? ???????? ????? ???????????? ??????? ??????? ?????????????: ß-AR (?) ?????????????????: ?-??????????????? (?) ????????? ?????????? (????????, ???????????, ????????) ????????????? : ????????????? ????????????? : ????????????? P. Barnes. N Engl Med J, 2000 ????????????? : ????????????? P. Barnes. N Engl Med J, 2000 Slide 17: O’Donnell DE Eur Respir Rev 2006; 15:37-41 ??????????? ????? EELV OE? ???????? ? ?????????? ????? ?????? ??? EELV ??? ???????? ? ?????????? ????? ?????? ??? ???? ??? ????? ??????????? ????? Slide 18: O’Donnell DE Eur Respir Rev 2006; 15:37-41 ??????????? ????? EELV OE? ???????? ? ?????????? ????? ?????? ??? EELV ??? ???????? ? ?????????? ????? ?????? ??? ??? ????? ??????????? ????? ??? ? ??????? ???? ??????? ??????? ???1 ?? ?????? ???????? ?????? ???????? ?????? : ? ??????? ???? ??????? ??????? ???1 ?? ?????? ???????? ?????? ???????? ?????? Liesker JJW Respir Med 2002 Dahl R. Am J Respir Crit Care Med Vol 164. pp 778–784, 2001 ?????????? 18 ??? ?????????? 9 ??? ??????????? 40 ??? ??????? ??? ???? ???????????: + p<0.001 vs ???????????; * p<0.05 vs ??????? * * * * * * ??. ???1, ?. 0 1 2 3 4 5 6 7 8 9 10 11 12 1.2 1.3 1.4 1.5 1.6 1.7 1.8 ?????, ????? ?????????, ???. ????? (???. 0) * * * + + + + + + + * + * + * * * * + * + *p<0.0001 ?? ????????? ? ??????? ????? ????????????? ????????, ???. ??? 9 10 11 * * ???? ?? Slide 20: P. Barnes. N Engl Med J, 2000 ???????????? ????????? ?????? ???????? TGF-a CTG ??????? ??????????? IL-8, LTB4, CXC-???????? ??????????? CD8+ ????????? ?????????? O2–, H2O2 OH?, ONOO– ?????? Slide 21: P. Barnes. N Engl Med J, 2000 ???????????? ????????? ?????? ???????? TGF-a CTG ??????? ??????????? IL-8, LTB4, CXC-???????? ??????????? CD8+ ????????? ?????????? O2–, H2O2 OH?, ONOO– ?????? ?? ??????????? ????????????? ???????? ??????????? ??????????? ? ????????? (Koyama 1992) ?? ??????????? ???????? ???????????? (Metzen 2003) ?? ??????????? ?????????? ???????????? ?????????? (Sato 1998) ?????????? ???????? ???????? ??????????????? ?????? ??????? (Gosens 2005) ??? ???????? ???????????? ß2-????????? : ??? ???????? ???????????? ß2-????????? van Noord JA. Eur Respir J 2000; 15: 878-885 % ?? ?????? ????? ???? ?????????? + ??????????? ?????????? ??????? 0 1-4 4-8 8-12 ???. 0 1-4 4-8 8-12 ???? ???? ? ??????????? ???? ???? ? ?????????????? ????????????? ????????? ??????????? SABA 120 100 80 60 40 20 0 80 60 40 20 0 You do not have the permission to view this presentation. In order to view it, please contact the author of the presentation.
Спирива Arkhipov Download Post to : URL : Related Presentations : Share Add to Flag Embed Email Send to Blogs and Networks Add to Channel Uploaded from authorPOINT lite Insert YouTube videos in PowerPont slides with aS Desktop Copy embed code: (To copy code, click on the text box) Embed: URL: Thumbnail: WordPress Embed Customize Embed The presentation is successfully added In Your Favorites. Views: 166 Category: Entertainment License: All Rights Reserved Like it (0) Dislike it (0) Added: June 15, 2009 This Presentation is Public Favorites: 0 Presentation Description No description available. Comments Posting comment... Premium member Presentation Transcript ??????????? ???????????? ??????????????????? ?????????? : ??????????? ???????????? ??????????????????? ?????????? Slide 2: M-ACh R M-ACh R a,ß-Adr R ???????????? ????? ????????????? ????? ???????????????? ?????, eg. n. vagus Slide 3: H-ACh R M1 a,ß-Adr R ???????????? ????? ????????????? ????? ???????????????? ?????, eg. n. vagus M2 M3 ????????? ?1 ? ?3 ?????????????????. ??? ?????? ??? ???????? ???????. ????????? M2 – ????????????????. ??? ???????? ???????? ???????. ??????????? – ???????? ???????? ????????????????? ??????? ??????? : Na+ ????? Ca++ M3 ????????????? ?????????????? ? ??????????? M2 ??????????? – ???????? ???????? ????????????????? ??????? ??????? ??????? ????????????????? ?????????? : ??????? ????????????????? ?????????? ?????? (M2): ????, ?????????????, ? ????????????. ??????: ????????????? ??????? ???????????: ????, ??????????? ?????????? ?? ??????? ??????. ???: ? ?????? ?????????, ? ?????? ??????????. ??????: ? ?????? ???????, ? ???????? ???????????? ?????. ??????????? ??????: ? ?????????, ??????????? ????????. ?-???????????? : ?-???????????? ??????????? ?????????? ???????? ??????? ???????? Slide 7: ???????????????? ???????? ????????????? ???????? ?????????????? ? ??????????????? ????????????????????? ?????????? ??????????? ????????? ?? ? ???? ?????????? ?????????? ?????????? ??????? ???? ????????? ?????? ????????? ? ???????? ????? ??????? ???? ???????????? ?????????? ???????? ?????????? ??????? ???? ???????? ????????: ????????????????? ???????: ???????? ?????? ??????? : ???????? ?????? ??????? ???????????? ??????? ??????? ?????????????: a-AR (???????????), ß-AR (?????????) ?????????????????: ?-??????????????? (???????????) ????????? ?????????? (????????, ???????????, ????????) ?????????????: NO ???????????????? ?????????? ? - ???????????????? : ???????????????? ?????????? ? - ???????????????? ??????? ????????????? : ??????? ????????????? Disse B et al. Life Sci 1999; 64:457-464 ???????????????? ???????? ???????????? ? ??????????? : ???????????????? ???????? ???????????? ? ??????????? van Noord JA et al. Thorax 2000; 55: 289-94 ???1 (?) ???? ????? ????????? 1.5 1.6 1.1 1.3 1.2 1.4 ???? ????? ????????? 1.5 1.6 1.1 1.3 1.2 1.4 92-? ???? 1-? ???? 0 5 -1 1 2 3 4 6 0 5 -1 1 2 3 4 6 ?????????? ??????????? ???1 (?) ???????? ?-????????????? ?? ?????????? ? ???????? ??????? : ???????? ?-????????????? ?? ?????????? ? ???????? ??????? COMBIVENT Inhalation Aerosol Study Group. Chest 1994; 105:1411-19 ???????? ???????? ????? : ???????? ???????? ????? ???????????? ??????? ??????? ?????????????: ß-AR (?) ?????????????????: ?-??????????????? (?) ????????? ?????????? (????????, ???????????, ????????) ????????????? : ????????????? ????????????? : ????????????? P. Barnes. N Engl Med J, 2000 ????????????? : ????????????? P. Barnes. N Engl Med J, 2000 Slide 17: O’Donnell DE Eur Respir Rev 2006; 15:37-41 ??????????? ????? EELV OE? ???????? ? ?????????? ????? ?????? ??? EELV ??? ???????? ? ?????????? ????? ?????? ??? ???? ??? ????? ??????????? ????? Slide 18: O’Donnell DE Eur Respir Rev 2006; 15:37-41 ??????????? ????? EELV OE? ???????? ? ?????????? ????? ?????? ??? EELV ??? ???????? ? ?????????? ????? ?????? ??? ??? ????? ??????????? ????? ??? ? ??????? ???? ??????? ??????? ???1 ?? ?????? ???????? ?????? ???????? ?????? : ? ??????? ???? ??????? ??????? ???1 ?? ?????? ???????? ?????? ???????? ?????? Liesker JJW Respir Med 2002 Dahl R. Am J Respir Crit Care Med Vol 164. pp 778–784, 2001 ?????????? 18 ??? ?????????? 9 ??? ??????????? 40 ??? ??????? ??? ???? ???????????: + p<0.001 vs ???????????; * p<0.05 vs ??????? * * * * * * ??. ???1, ?. 0 1 2 3 4 5 6 7 8 9 10 11 12 1.2 1.3 1.4 1.5 1.6 1.7 1.8 ?????, ????? ?????????, ???. ????? (???. 0) * * * + + + + + + + * + * + * * * * + * + *p<0.0001 ?? ????????? ? ??????? ????? ????????????? ????????, ???. ??? 9 10 11 * * ???? ?? Slide 20: P. Barnes. N Engl Med J, 2000 ???????????? ????????? ?????? ???????? TGF-a CTG ??????? ??????????? IL-8, LTB4, CXC-???????? ??????????? CD8+ ????????? ?????????? O2–, H2O2 OH?, ONOO– ?????? Slide 21: P. Barnes. N Engl Med J, 2000 ???????????? ????????? ?????? ???????? TGF-a CTG ??????? ??????????? IL-8, LTB4, CXC-???????? ??????????? CD8+ ????????? ?????????? O2–, H2O2 OH?, ONOO– ?????? ?? ??????????? ????????????? ???????? ??????????? ??????????? ? ????????? (Koyama 1992) ?? ??????????? ???????? ???????????? (Metzen 2003) ?? ??????????? ?????????? ???????????? ?????????? (Sato 1998) ?????????? ???????? ???????? ??????????????? ?????? ??????? (Gosens 2005) ??? ???????? ???????????? ß2-????????? : ??? ???????? ???????????? ß2-????????? van Noord JA. Eur Respir J 2000; 15: 878-885 % ?? ?????? ????? ???? ?????????? + ??????????? ?????????? ??????? 0 1-4 4-8 8-12 ???. 0 1-4 4-8 8-12 ???? ???? ? ??????????? ???? ???? ? ?????????????? ????????????? ????????? ??????????? SABA 120 100 80 60 40 20 0 80 60 40 20 0