logging in or signing up Бронхиальная астма Arkhipov Download Post to : URL : Related Presentations : Share Add to Flag Embed Email Send to Blogs and Networks Add to Channel Uploaded from authorPOINT lite Insert YouTube videos in PowerPont slides with aS Desktop Copy embed code: (To copy code, click on the text box) Embed: URL: Thumbnail: WordPress Embed Customize Embed The presentation is successfully added In Your Favorites. Views: 199 Category: Science & Tech.. License: All Rights Reserved Like it (0) Dislike it (0) Added: June 15, 2009 This Presentation is Public Favorites: 0 Presentation Description No description available. Comments Posting comment... Premium member Presentation Transcript ???????????? ????? : ???????????? ????? 15 ???? 2009 ?. ??????????? : ??????????? ???????????? ????? – ??????????? ????????????? ???????????, ??????? ???????????????: ????????????? ??????????? ????????? ?????, ??????????? ????????? ?????, ???????? ?????? ??????? ? ????? ?? ?????????? ???????. ????????????? : ????????????? 1. Morbidity & Mortality Weekly Report, 2001. 2. Asthma Physician Market Dynamics Study, 2001. 3. National Center for Health Statistics, 1986-1999. 4. Scott Levin, PDDA, MAT 12/01. 5-10% ??????-??? 32% ?? 18 ??? 68% =18 ??? 18% ??????? 34% ??????-??? 22% ?????? 26% ???????? ? ????? 5,4% ????? ????… 7,2% ????? ??????… 11,7% ???-???? 55% ??????? 45% ??????????- ??????? ??????? ???? ??? ???????? ?????????????????? ????? : ?????????????????? ????? Global Burden of Asthma, 2004 ?????????????????? ????? : ?????????????????? ????? Global Burden of Asthma, 2004 ?????????? ?? ?? : ?????????? ?? ?? Global Burden of Asthma ???????? ???????????? ????? : ???????? ???????????? ????? Yang IA et al. Thorax 2008;63;555-563 ????????: ???????? ??????? ??????????? ????????: ? ?????? ?? INF-ß ????????: ?????????? ?????????? ???????????. ?????????????? ? ?????? ????? ? ?????? : ????? ? ?????? ? van Motius J Allergy Clin Immunol 2004;113:373-9 1,3% 5,9% 1,8% 4,4% 3,1% 12,9% ????????? : ????????? Grootendorst DC et al., AJRCCM 2000;161:A918 ??????? ????? ?? ???????? ?????????????????????? ?????? : ??????? ????? ?? ???????? ?????????????????????? ?????? Paul Blanc, 2004 ???????????????? ????????? ??????? ????? ??????????? ?????. ????? ??????? / ????????. ?????. ??????? ???????? ????????????? ????????? ??????? ????????????? ??????????? : ????????????? ??????????? ten Brinke A et al. Eur Respir J 2005; 26: 812–818. % - ?????? ?????????? - ??????? ???????? ????? ?? ??? ??????. ??????????? ??????? ???? ???????? Slide 14: ?????????????????????? ?????? ???????????? ?????????? ?????? ?????? : ?????? ?????? Slide 16: ? Barnes Immunology 2008; Vol 8: 183-192 ????????? ?? : ????????? ?? ???????????? ??????? ??????? ??????? ????? ?????????? ??????????? ????? ??????????? ???????????????? ??????????????? ????????????????? ???????? ????? ???????????? ?????????:????????? ? ??????? ?? : ???????????? ?????????:????????? ? ??????? ?? Wenzel ARJCCM 1997;156:737-743 ? Barnes Immunology 2008; Vol 8: 183-192 ???????? ??????????? ????? : ???????? ??????????? ????? Holloway et al. Asthma and Rhinitis.1995. ????????? ?????? : ????????? ?????? ?????? ?????? : ?????? ?????? Holloway et al. Asthma and Rhinitis.1995. ??????????? ???? : ??????????? ???? Carroll et al. ARRD 1993; 147:405-410 ??????? ????????? ?????, ?? ??????????????? ??????? : ??????????????? ??????? ????? 11 ??? ??????? ?? 11 ??? ????????????? : ????????????? ????? – ??????????????? ??????????? : ????? – ??????????????? ??????????? ? Bai TR et al. Eur Respir J 2007; 30: 452–456 ? Jenkins HA et al J Allergy Clin Immunol 2002; 109: 3-13 ??????? ???1, ? ????????? ????1: ?????? ?????????? - 14,6 ??/??? ?????? ?????????? - 31,5 ??/??? ??????? : ??????? ??????????? ????????: ????????????? ??????, ???????????? ??????? ?????? ??????????? / ?????????????: ???????????? ???????????????? ??????????? ???????????????? ?????????????? ????????????????? ???????????? ? ????????? ? ??????????? ???????????? ??????????? ? ?????????? ?? – ???????????????????? ???? ????????????? : ????????????? ??????? ????? ?? GINA 1996 : ??????? ????? ?? GINA 1996 ??????????????? ????????????? ??? ??? : ??????????????? ????????????? ??? ??? * - ???????? ????? ????????? 1 ??? ? ???? ??? ????????? ?? ??????? ???????? : ??????? ???????? ??????? ? ??????????? ?????????? ??, ?????? ???? – ??????????? ??-?? ????????? ??. D-s: ??????? ?????????????? ??. ???????: ????????? 2000 ???/???. ?????? 3 ???.: ???????? ?? – 1-2 ???? ? ???. ?????? ????????? ???. D-s: ? ???????: ??? ??????? ????? ?? GINA 2002 : ??????? ????? ?? GINA 2002 ???????????? ???????????? ???????????? ????? ? ?????? (120 ?????? ? 1362 ??????? ?? 34 ??????? ??) : ???????????? ???????????? ???????????? ????? ? ?????? (120 ?????? ? 1362 ??????? ?? 34 ??????? ??) ? 55,2% ??????? ????? ??????????? ????????? ??????? ??????? ?? ? 84% ??????? ????????? ??????????? ??????? ??????? ?? ???? ???? ? ?????????? ??????? ??. ??????? ?.?., ??? ?.?., ??????? ?.?., ????????? ?.?. ?????????????, 2006; ?6: ?. 94-102 GINA 2006 : GINA 2006 «??????» ????????????? ??????? ?? ????????? ? ??????? ??????? ?? ?????? ?????????, ??? ?? ??????????????. ??????? ?? ????? ?????????? ? ???????? ??????? ? ??????? ?? ?????? ?? ????????? ?????? ???????????, ?? ? ?? ?????? ?? ???????. ???????????? ????? ????? ??????????? ?? ??????? ??????? ? ???????????? ? ?????????? GINA 1996. ?? ??????? ?? ?? ??????? ????? ???????????? ??? ??????? ???????? ? ?????? ???????? ??????? ????????. ??? ???????????? ????? ??????? ????????????? ????????????? ?? ?? ?????? ???????? ??? ????????????. GINA 2006 GINA 2006/07: ???????? ??? ???????????? : GINA 2006/07: ???????? ??? ???????????? GINA 2006-07 ?????? ?? «??????? ??» ???????? ?????? ????????.. : ?????? ?? «??????? ??» ???????? ?????? ????????.. Taylor DR et al. Eur Respir J 2008; 32: 545–554 ??????? ?? ?????????????? ? ??????? (??? ???????????? ??) ????????????? ???????????: ???????, ??????????????? ???????? ??????????? ? ???????? ????????? ???????, ?? ??????? ????????: ????????????? ?????????, ?????????? ??????? ? ??????????, ???????. ??????? ????? : ??????? ????? ?????????? 1000 ???/???. ???????? ???? – 1-2 ???? ? ???. ?????? ??????????? – 1-2 ???? ? ???. ???????????: ????? ?????????? 1000 ???/???. ???????? – ?????????. ?????? ??????????? – ?????? ????. ???1 = 50% ?? ????????. ???????/???????????? ? ??????? ?? (???????? ATS) : ???????/???????????? ? ??????? ?? (???????? ATS) ???? ??? ??? ??????? ????????: ????? ??? ?????? = ½ ???? ? ???? ????? ??????? ??? ???? ?????????????? ????????: ????????????? ????????? ?????????????? ???????? (?????????, ????-LT) ?????????? ??????????? ? SABA ?????????? ???????????????? (???1<80% ?? ????????) ???????? ????? ??? ?????? =3 ??? ? ??? ????????? ?? ?????? ??????????? ??????? =1 ???? ? ??? ??????? ????????? ????????? ??? ???????? ???? ??? ?? 25% ?????????? ????? ?????????? ?? ? ???????? American Thoracic SocietyWorkshop. Proceedings of the ATS workshop on refractory asthma. Current understanding, recommendations, and unanswered questions. Am J Respir Crit Care Med 2000;162:2341-51. ??????? ??????? ????? : ??????? ??????? ????? Wenzel SE et al. , Am J Respir Crit Care Med 2000;162:2341-51. ??????? ?????????????? ??? ? ????????????? ???? : ??????? ?????????????? ??? ? ????????????? ???? ????? ???????????? GOAL : ???????????? GOAL Bateman ED et al. Am J Respir Crit Care Med 2004;170:836-844. ? ????? ???????????? GOAL 1000 ??? FLU ???????? 68% ??????? ? ?????? ???????? ? 72% ??????? ? ?????? ??????????. ???? ??????? ? ?????????????? ?????? : ???? ??????? ? ?????????????? ?????? 70 60 50 40 30 20 10 GOAL & SUND EXCEL ???????? GINA Slide 43: ???????? ?????????? ??????????? ????? ?????????? ????????? ?? ?????? ????????, ??? ?????????? ?????????????? : ?????????? ????????? ?? ?????? ????????, ??? ?????????? ?????????????? 0 100 200 400 600 800 ???? ??????????, ??? 100 80 60 40 20 0 % ?? max Pedersen S. et al. J. Allergy Clin. Immunol. 1995; 95:29–33. Alving, K., et al. Am. J. Respir. Crit. Care Med. 1995; 151:A129. Slide 45: ??? ??????? + 8% ? 2,7 ???? ??? ??? ??? 200 ??? 800 ??? + LABA ? 1,7 ???? + 10% + 31% - 36% ??????? ???????? ???? ?????????? O’Byrne MP et al. AJRCCM, 2001 Pauwels RA et al. NEMJ, 1997 ???????, ?? ??????? ?????????? ?????????? ???????? ? ??????????? ???????: : ???????, ?? ??????? ?????????? ?????????? ???????? ? ??????????? ???????: ??????? (?? ????? ¼ ???? ???????? ???????) ????????? ?? ? ???? (?? ????? 10% ???????) ???????? ???????? ?????????? ?????????? ??????? ?????????? ?????? ????????? ???????? ?????????????????? ??????? ?????????? ???-??????????? ???????????? «??????»: ??????? ??????????, ????????? ????? ß-?????????? ??????????????? ???????? Humbert M., Allergy 2007: 62: 95–101 ??????? ? ???????? ??? ?? : ??????? ? ???????? ??? ?? ????????? ????? ??? ?? ?????, ??? ????????. ? ??????? ??????? ?? ??????? ???????? ????, ? ??????? ????????? ?? ???. ??????? – ????, ??? ? ?????????. ? ??????? ?????????? ???????????? ????????? ?????????? ????, ? ???????? ????? – ????. ??????? ????????????? ? ????? ???????? ??????? ????????? ?????? ???1. ????????? ??????? ???????? ???????? ??? ?? ? ? ???????? ? ? ?????. ??????? ??????? ????????????? ???. ? ??????? ??????????: ???????????? ? ??? ????????????? ???????? ??????????. ??????????? ?????????????????-2 ??????? TNF-a ? IL-8. Wakefield M. Aust N Z J Med 1995; Boulet LP Chest 2006; Eisner MD Am J Respir Crit Care Med 1998; Lange P N Engl J Med 1998; Bousquet J Allergy 2001; Chalmers GW Thorax 2002; Chaudhuri R Am J Respir Crit Care Med 2003; Chalmers GW Chest 2001; Ito K FASEB J 2001; Keatings VM Am J Respir Crit Care Med 1996; Gagliardo R Am J Respir Crit Care Med 2003; ??????????? ??????? ???????? ??? ?????? : ??????????? ??????? ???????? ??? ?????? ???????? ??? ?????????? «??????» ???????? ?????????? ???1 ?????????? ??? ??????????? ? SABA ????, ???????, ????????? (????. ????) ?????? ???????? ??? ?????? ??????????? ? ??????? 13-14 ???. ? ???????? ? ?????? ????????? ??????????? ?????????? ????? ? ????????? ????: 27% (?????? 3). Bateman ED et al. Allergy 2008: 63: 932–938 ?????? ????????? ???????? ? ?????????? : ?????? ????????? ???????? ? ?????????? Dahl R. et al. Respir Med, 2006; Vol. 100: 152–1162. Aalbers R at al. Current Med Res and Opinion VOL. 20, NO. 2, 2004, 225–240 Kuna P et al. Abstract presented at the ERS Congress 2006 Bousquet J. et al. Abstract presented at the ERS Congress 2008 Vogelmeier C. et al. Eur Respir J 2005; 26: 819–828 ??????????? ??????? ???????? ??? ?????? : ??????????? ??????? ???????? ??? ?????? ???????? ??? ?????????? «??????» ???????? ?????????? ???1 ?????????? ??? ??????????? ? SABA ????, ???????, ????????? (????. ????) ???????? ?????????? ?? : ???????? ?????????? ?? ??????? ?????????? : ??????? ?????????? ??????????? : ??????????? «??????, ??????, ?? ????, ??? ?????????» ?.?. ?????? ???????? ?????????? : ???????? ?????????? Wark PAB et al. Clin Exp Allergy 2002;32:1750–6. ????????? ????????? ????????????? ?????????? ?? : ????????? ????????? ????????????? ?????????? ?? Slide 56: ???????? ????? Th-2 ????????? ????. ?????? IL-5 IL-8 ????????? ????????? ?????? ?????? ???????????? ?????? / ?????????? ?? ?-????????? ?????????? ????? : ?????????? ????? Tattersfield: Am J Respir Crit Care Med 160:594–599, 1999 100 80 60 40 20 0 -15 -5 -10 5 0 10 15 ??? (?? ? ????? ??????????) ????? SABA ???????? ??? ?????? ???????? You do not have the permission to view this presentation. In order to view it, please contact the author of the presentation.
Бронхиальная астма Arkhipov Download Post to : URL : Related Presentations : Share Add to Flag Embed Email Send to Blogs and Networks Add to Channel Uploaded from authorPOINT lite Insert YouTube videos in PowerPont slides with aS Desktop Copy embed code: (To copy code, click on the text box) Embed: URL: Thumbnail: WordPress Embed Customize Embed The presentation is successfully added In Your Favorites. Views: 199 Category: Science & Tech.. License: All Rights Reserved Like it (0) Dislike it (0) Added: June 15, 2009 This Presentation is Public Favorites: 0 Presentation Description No description available. Comments Posting comment... Premium member Presentation Transcript ???????????? ????? : ???????????? ????? 15 ???? 2009 ?. ??????????? : ??????????? ???????????? ????? – ??????????? ????????????? ???????????, ??????? ???????????????: ????????????? ??????????? ????????? ?????, ??????????? ????????? ?????, ???????? ?????? ??????? ? ????? ?? ?????????? ???????. ????????????? : ????????????? 1. Morbidity & Mortality Weekly Report, 2001. 2. Asthma Physician Market Dynamics Study, 2001. 3. National Center for Health Statistics, 1986-1999. 4. Scott Levin, PDDA, MAT 12/01. 5-10% ??????-??? 32% ?? 18 ??? 68% =18 ??? 18% ??????? 34% ??????-??? 22% ?????? 26% ???????? ? ????? 5,4% ????? ????… 7,2% ????? ??????… 11,7% ???-???? 55% ??????? 45% ??????????- ??????? ??????? ???? ??? ???????? ?????????????????? ????? : ?????????????????? ????? Global Burden of Asthma, 2004 ?????????????????? ????? : ?????????????????? ????? Global Burden of Asthma, 2004 ?????????? ?? ?? : ?????????? ?? ?? Global Burden of Asthma ???????? ???????????? ????? : ???????? ???????????? ????? Yang IA et al. Thorax 2008;63;555-563 ????????: ???????? ??????? ??????????? ????????: ? ?????? ?? INF-ß ????????: ?????????? ?????????? ???????????. ?????????????? ? ?????? ????? ? ?????? : ????? ? ?????? ? van Motius J Allergy Clin Immunol 2004;113:373-9 1,3% 5,9% 1,8% 4,4% 3,1% 12,9% ????????? : ????????? Grootendorst DC et al., AJRCCM 2000;161:A918 ??????? ????? ?? ???????? ?????????????????????? ?????? : ??????? ????? ?? ???????? ?????????????????????? ?????? Paul Blanc, 2004 ???????????????? ????????? ??????? ????? ??????????? ?????. ????? ??????? / ????????. ?????. ??????? ???????? ????????????? ????????? ??????? ????????????? ??????????? : ????????????? ??????????? ten Brinke A et al. Eur Respir J 2005; 26: 812–818. % - ?????? ?????????? - ??????? ???????? ????? ?? ??? ??????. ??????????? ??????? ???? ???????? Slide 14: ?????????????????????? ?????? ???????????? ?????????? ?????? ?????? : ?????? ?????? Slide 16: ? Barnes Immunology 2008; Vol 8: 183-192 ????????? ?? : ????????? ?? ???????????? ??????? ??????? ??????? ????? ?????????? ??????????? ????? ??????????? ???????????????? ??????????????? ????????????????? ???????? ????? ???????????? ?????????:????????? ? ??????? ?? : ???????????? ?????????:????????? ? ??????? ?? Wenzel ARJCCM 1997;156:737-743 ? Barnes Immunology 2008; Vol 8: 183-192 ???????? ??????????? ????? : ???????? ??????????? ????? Holloway et al. Asthma and Rhinitis.1995. ????????? ?????? : ????????? ?????? ?????? ?????? : ?????? ?????? Holloway et al. Asthma and Rhinitis.1995. ??????????? ???? : ??????????? ???? Carroll et al. ARRD 1993; 147:405-410 ??????? ????????? ?????, ?? ??????????????? ??????? : ??????????????? ??????? ????? 11 ??? ??????? ?? 11 ??? ????????????? : ????????????? ????? – ??????????????? ??????????? : ????? – ??????????????? ??????????? ? Bai TR et al. Eur Respir J 2007; 30: 452–456 ? Jenkins HA et al J Allergy Clin Immunol 2002; 109: 3-13 ??????? ???1, ? ????????? ????1: ?????? ?????????? - 14,6 ??/??? ?????? ?????????? - 31,5 ??/??? ??????? : ??????? ??????????? ????????: ????????????? ??????, ???????????? ??????? ?????? ??????????? / ?????????????: ???????????? ???????????????? ??????????? ???????????????? ?????????????? ????????????????? ???????????? ? ????????? ? ??????????? ???????????? ??????????? ? ?????????? ?? – ???????????????????? ???? ????????????? : ????????????? ??????? ????? ?? GINA 1996 : ??????? ????? ?? GINA 1996 ??????????????? ????????????? ??? ??? : ??????????????? ????????????? ??? ??? * - ???????? ????? ????????? 1 ??? ? ???? ??? ????????? ?? ??????? ???????? : ??????? ???????? ??????? ? ??????????? ?????????? ??, ?????? ???? – ??????????? ??-?? ????????? ??. D-s: ??????? ?????????????? ??. ???????: ????????? 2000 ???/???. ?????? 3 ???.: ???????? ?? – 1-2 ???? ? ???. ?????? ????????? ???. D-s: ? ???????: ??? ??????? ????? ?? GINA 2002 : ??????? ????? ?? GINA 2002 ???????????? ???????????? ???????????? ????? ? ?????? (120 ?????? ? 1362 ??????? ?? 34 ??????? ??) : ???????????? ???????????? ???????????? ????? ? ?????? (120 ?????? ? 1362 ??????? ?? 34 ??????? ??) ? 55,2% ??????? ????? ??????????? ????????? ??????? ??????? ?? ? 84% ??????? ????????? ??????????? ??????? ??????? ?? ???? ???? ? ?????????? ??????? ??. ??????? ?.?., ??? ?.?., ??????? ?.?., ????????? ?.?. ?????????????, 2006; ?6: ?. 94-102 GINA 2006 : GINA 2006 «??????» ????????????? ??????? ?? ????????? ? ??????? ??????? ?? ?????? ?????????, ??? ?? ??????????????. ??????? ?? ????? ?????????? ? ???????? ??????? ? ??????? ?? ?????? ?? ????????? ?????? ???????????, ?? ? ?? ?????? ?? ???????. ???????????? ????? ????? ??????????? ?? ??????? ??????? ? ???????????? ? ?????????? GINA 1996. ?? ??????? ?? ?? ??????? ????? ???????????? ??? ??????? ???????? ? ?????? ???????? ??????? ????????. ??? ???????????? ????? ??????? ????????????? ????????????? ?? ?? ?????? ???????? ??? ????????????. GINA 2006 GINA 2006/07: ???????? ??? ???????????? : GINA 2006/07: ???????? ??? ???????????? GINA 2006-07 ?????? ?? «??????? ??» ???????? ?????? ????????.. : ?????? ?? «??????? ??» ???????? ?????? ????????.. Taylor DR et al. Eur Respir J 2008; 32: 545–554 ??????? ?? ?????????????? ? ??????? (??? ???????????? ??) ????????????? ???????????: ???????, ??????????????? ???????? ??????????? ? ???????? ????????? ???????, ?? ??????? ????????: ????????????? ?????????, ?????????? ??????? ? ??????????, ???????. ??????? ????? : ??????? ????? ?????????? 1000 ???/???. ???????? ???? – 1-2 ???? ? ???. ?????? ??????????? – 1-2 ???? ? ???. ???????????: ????? ?????????? 1000 ???/???. ???????? – ?????????. ?????? ??????????? – ?????? ????. ???1 = 50% ?? ????????. ???????/???????????? ? ??????? ?? (???????? ATS) : ???????/???????????? ? ??????? ?? (???????? ATS) ???? ??? ??? ??????? ????????: ????? ??? ?????? = ½ ???? ? ???? ????? ??????? ??? ???? ?????????????? ????????: ????????????? ????????? ?????????????? ???????? (?????????, ????-LT) ?????????? ??????????? ? SABA ?????????? ???????????????? (???1<80% ?? ????????) ???????? ????? ??? ?????? =3 ??? ? ??? ????????? ?? ?????? ??????????? ??????? =1 ???? ? ??? ??????? ????????? ????????? ??? ???????? ???? ??? ?? 25% ?????????? ????? ?????????? ?? ? ???????? American Thoracic SocietyWorkshop. Proceedings of the ATS workshop on refractory asthma. Current understanding, recommendations, and unanswered questions. Am J Respir Crit Care Med 2000;162:2341-51. ??????? ??????? ????? : ??????? ??????? ????? Wenzel SE et al. , Am J Respir Crit Care Med 2000;162:2341-51. ??????? ?????????????? ??? ? ????????????? ???? : ??????? ?????????????? ??? ? ????????????? ???? ????? ???????????? GOAL : ???????????? GOAL Bateman ED et al. Am J Respir Crit Care Med 2004;170:836-844. ? ????? ???????????? GOAL 1000 ??? FLU ???????? 68% ??????? ? ?????? ???????? ? 72% ??????? ? ?????? ??????????. ???? ??????? ? ?????????????? ?????? : ???? ??????? ? ?????????????? ?????? 70 60 50 40 30 20 10 GOAL & SUND EXCEL ???????? GINA Slide 43: ???????? ?????????? ??????????? ????? ?????????? ????????? ?? ?????? ????????, ??? ?????????? ?????????????? : ?????????? ????????? ?? ?????? ????????, ??? ?????????? ?????????????? 0 100 200 400 600 800 ???? ??????????, ??? 100 80 60 40 20 0 % ?? max Pedersen S. et al. J. Allergy Clin. Immunol. 1995; 95:29–33. Alving, K., et al. Am. J. Respir. Crit. Care Med. 1995; 151:A129. Slide 45: ??? ??????? + 8% ? 2,7 ???? ??? ??? ??? 200 ??? 800 ??? + LABA ? 1,7 ???? + 10% + 31% - 36% ??????? ???????? ???? ?????????? O’Byrne MP et al. AJRCCM, 2001 Pauwels RA et al. NEMJ, 1997 ???????, ?? ??????? ?????????? ?????????? ???????? ? ??????????? ???????: : ???????, ?? ??????? ?????????? ?????????? ???????? ? ??????????? ???????: ??????? (?? ????? ¼ ???? ???????? ???????) ????????? ?? ? ???? (?? ????? 10% ???????) ???????? ???????? ?????????? ?????????? ??????? ?????????? ?????? ????????? ???????? ?????????????????? ??????? ?????????? ???-??????????? ???????????? «??????»: ??????? ??????????, ????????? ????? ß-?????????? ??????????????? ???????? Humbert M., Allergy 2007: 62: 95–101 ??????? ? ???????? ??? ?? : ??????? ? ???????? ??? ?? ????????? ????? ??? ?? ?????, ??? ????????. ? ??????? ??????? ?? ??????? ???????? ????, ? ??????? ????????? ?? ???. ??????? – ????, ??? ? ?????????. ? ??????? ?????????? ???????????? ????????? ?????????? ????, ? ???????? ????? – ????. ??????? ????????????? ? ????? ???????? ??????? ????????? ?????? ???1. ????????? ??????? ???????? ???????? ??? ?? ? ? ???????? ? ? ?????. ??????? ??????? ????????????? ???. ? ??????? ??????????: ???????????? ? ??? ????????????? ???????? ??????????. ??????????? ?????????????????-2 ??????? TNF-a ? IL-8. Wakefield M. Aust N Z J Med 1995; Boulet LP Chest 2006; Eisner MD Am J Respir Crit Care Med 1998; Lange P N Engl J Med 1998; Bousquet J Allergy 2001; Chalmers GW Thorax 2002; Chaudhuri R Am J Respir Crit Care Med 2003; Chalmers GW Chest 2001; Ito K FASEB J 2001; Keatings VM Am J Respir Crit Care Med 1996; Gagliardo R Am J Respir Crit Care Med 2003; ??????????? ??????? ???????? ??? ?????? : ??????????? ??????? ???????? ??? ?????? ???????? ??? ?????????? «??????» ???????? ?????????? ???1 ?????????? ??? ??????????? ? SABA ????, ???????, ????????? (????. ????) ?????? ???????? ??? ?????? ??????????? ? ??????? 13-14 ???. ? ???????? ? ?????? ????????? ??????????? ?????????? ????? ? ????????? ????: 27% (?????? 3). Bateman ED et al. Allergy 2008: 63: 932–938 ?????? ????????? ???????? ? ?????????? : ?????? ????????? ???????? ? ?????????? Dahl R. et al. Respir Med, 2006; Vol. 100: 152–1162. Aalbers R at al. Current Med Res and Opinion VOL. 20, NO. 2, 2004, 225–240 Kuna P et al. Abstract presented at the ERS Congress 2006 Bousquet J. et al. Abstract presented at the ERS Congress 2008 Vogelmeier C. et al. Eur Respir J 2005; 26: 819–828 ??????????? ??????? ???????? ??? ?????? : ??????????? ??????? ???????? ??? ?????? ???????? ??? ?????????? «??????» ???????? ?????????? ???1 ?????????? ??? ??????????? ? SABA ????, ???????, ????????? (????. ????) ???????? ?????????? ?? : ???????? ?????????? ?? ??????? ?????????? : ??????? ?????????? ??????????? : ??????????? «??????, ??????, ?? ????, ??? ?????????» ?.?. ?????? ???????? ?????????? : ???????? ?????????? Wark PAB et al. Clin Exp Allergy 2002;32:1750–6. ????????? ????????? ????????????? ?????????? ?? : ????????? ????????? ????????????? ?????????? ?? Slide 56: ???????? ????? Th-2 ????????? ????. ?????? IL-5 IL-8 ????????? ????????? ?????? ?????? ???????????? ?????? / ?????????? ?? ?-????????? ?????????? ????? : ?????????? ????? Tattersfield: Am J Respir Crit Care Med 160:594–599, 1999 100 80 60 40 20 0 -15 -5 -10 5 0 10 15 ??? (?? ? ????? ??????????) ????? SABA ???????? ??? ?????? ????????