Research Presentation College Station

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American Heart Association Texas Affiliate Brent Fields Vice President Research Administration & State Health Alliances

Research AHA Top Priority: 

Research AHA Top Priority The AHA believes that learning more about the #1 and #3 killers in America is one of the best ways to accomplish our mission: Impact Goal: By 2010, we will reduce coronary heart disease, stroke and risk by 25 percent.

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The AHA’s commitment to research is reflected in our strategic plan: Increasing the capacity of the research community to generate the highest quality research; Identifying critical research agendas and increasing the understanding of specific cardiovascular issues.

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Research Expense for Major National Health Agencies: 2004 A American Cancer Society B Alzheimer’s Association C American Diabetes Association D National Multiple Sclerosis Society E March of Dimes F Muscular Dystrophy Association G Juvenile Diabetes Association H American Heart Association

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AHA’s 2004-05 EXPENDITURES AHA National Budget Expenditures

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How each dollar is spent Donor Dollar 28.5% 25¢ 75¢ National Center Texas Affiliate Research Allocation 15¢ 13.5¢

Nobel Prize Recipients funded by AHA: 

Nobel Prize Recipients funded by AHA 1937 – Dr. Albert Szent-Gyorgyi 1971 – Dr. Earl Sutherland 1985 – Dr. Joseph Goldstein 1985 – Dr. Michael Brown 1992 – Dr. Edwin Krebs 1998 – Dr. Robert Furchgott 2003 – Dr. Peter Agre

Milestones: 

Milestones 1956 - Dr. Ancel Keys, supported by funding from the Minnesota Affiliate, first links dietary fat with cholesterol. This discovery spurs the AHA to assume a leading role in urging Americans to change their eating habits. 1956 - Dr. Paul Zoll, aided by the Massachusetts Affiliate, publishes the first report of the successful ending of ventricular fibrillation in humans by externally applied countershock. 1957 - Dr. William Wierich, assisted by support from the Minnesota Affiliate and joined by Drs. Vincent Gott and Walter Lillehei, implants the first externally powered pacemaker in a patient with a surgical heart blockage. 1960 - Dr. Albert Starr performs the first long-term successful mitral valve replacement with a caged ball valve, ushering in a new era of valve replacement. He was supported in developing the artificial heart valve by the Oregon Affiliate and assisted by engineer Lowell Edwards. 1961 - Dr. Julius Jacobsen, with funding from the Vermont Affiliate, begins performing surgery with the aid of a microscope. Microsurgery ultimately leads to changes in coronary artery surgery, plastic surgery, neurosurgery, gynecology, limb reimplantation, and orthopedic and tumor surgery. 1985 - Drs. Joseph Goldstein and Michael Brown, sponsored by the AHA in 1972, 1973 and 1975, are awarded the Nobel Prize in Physiology or Medicine for their research on the role of low- density lipoprotein receptors in controlling blood cholesterol levels. Their research provides new insights into the ways fatty cholesterol enters body cells and why cholesterol levels may become too high.

Texas Research Statistics: 

Texas Research Statistics FY 06-07 there are currently 150 Texas Researchers funded by the AHA (TX Affiliate = 94; National = 56) FY 06-07 total amount funded =$8,977,708 (TX Affiliate = $4,929,265; National = $4,048,443) 2000-2008 total funding = $67,993,077 (TX Affiliate = $36,611,162; National $31,381,915) $29,893,969 (current total committed National and TXA) Currently 11 cities and 22 institutions are represented by funded researchers in Texas 100+ Texas researchers participated in our TXA Peer Review in 2006 There are currently 15 Research Allocations and Advisory Committee Members (RAAC)

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College Station Statistics Texas A&M University Health Science Center TXA Applications received/funded for the 2006 cycle = 0/0 TXA Applications received/funded 2000-2006 = 1/1 2 Active Researchers = TXA - 1; National – 1 1 Previous LBJ Award Recipients 0 Previous Outstanding Postdoctoral Fellowship Award Recipient $127,000 in Active AHA grants (FY 06-07 actual spent) (TXA - $62,000; National - $65,000) $384,000 Total Committed FY 06-07 (TXA & National combined) $508,000 in AHA funding (2000-2008 allocated) (TXA - $248,000; National - $260,000) Current Research Allocations & Advisory Committee Members = 0

College Station Statistics: 

College Station Statistics Texas A&M University TXA Applications received/funded for the 2006 cycle – 21/1 TXA Applications received/funded 2000-2006 = 95/18 3 Active Researchers (TXA - 3; National – 0) 2 Previous LBJ Award Recipients 0 Previous Outstanding Postdoctoral Fellowship Applicant Award $172,750 Active AHA grants for FY 06-07 (TXA - $172,750; National - $0) $378,000 Total Committed FY 06-07 (TXA & National combined) $2,613,000 in AHA funding (2000-2008 allocated) (TXA - $2,184,000; National - $429,000) Current Research Allocations & Advisory Committee Members = 0

College Station Statistics: 

College Station Statistics Texas Agricultural Experiment Station TXA Applications received/funded for the 2006 cycle – 0/0 TXA Applications received/funded 2000-2006 = 0/0 1 Active Researchers (TXA - 0; National – 1) 0 Previous LBJ Award Recipients 0 Previous Outstanding Postdoctoral Fellowship Applicant Award $48,750 Active AHA grants for FY 06-07 (TXA - $0; National - $48,750) $260,000 Total Committed FY 06-07 (TXA & National combined) $260,000 in AHA funding (2000-2008 allocated) (TXA - $0; National - $260,000) Current Research Allocations & Advisory Committee Members = 0 Texas Engineering Experiment Station TXA Applications received/funded for the 2006 cycle – 0/0 TXA Applications received/funded 2000-2006 = 0/0 1 Active Researchers (TXA - 0; National – 1) 0 Previous LBJ Award Recipients 0 Previous Outstanding Postdoctoral Fellowship Applicant Award $65,000 Active AHA grants for FY 06-07 (TXA - $0; National - $65,000) $260,000 Total Committed FY 06-07 (TXA & National combined) $260,000 in AHA funding (2000-2008 allocated) (TXA - $0; National - $260,000) Current Research Allocations & Advisory Committee Members = 0

College Station Statistics: 

College Station Statistics Currently funded Researchers TEXAS A&M UNIVERSITY HEALTH SCIENCE CENTER Texas Affiliate 2005-07 Emily Wilson, PhD Grant-in-Aid Matrix-dependent modulation of SRF- mediated transcription bycyclic stretch in vascular smooth muscle National Center 2005-08 Kayla Bayless, PhD Scientist Development Grant The effects of TIMP-3 and TGF-beta on metalloproteinase-mediated 3-D capillary network formation and stabilization TEXAS A&M UNIVERSITY Texas Affiliate 2005-07 John Lawler, PhD Grant-in-Aid Exercise Training Protects Against Pro-apoptotic Signaling in the Aging Heart 2005-07 Christopher Quick, PhD Beginning Grant-in-Aid Matching supply to demand: impact of structural adaptation of vascularnetworks on autoregulation] 2006-08 Patricia LiWang, PhD Grant-in-Aid A study of the structural basis of the anti-inflammatory activity of thechemokine homolog vMIP-II

College Station Statistics: 

College Station Statistics TEXAS ENGINEERING EXPERIMENT STATION National Center 2004-08 John Criscione, MD Scientist Development Grant Cardiac Mechanobiology in Ventricular Growth, Remodeling, and Recovery TEXAS AGRICULTURAL EXPERIMENT STATION National Cente r2003-12/06 Cristine Heaps, PhD Scientist Development Grant Voltage-dependent K+ channel isoforms contributing to adenosine-mediated relaxation

TAMU SYSTEM: 

TAMU SYSTEM

Research Focus: 

Research Focus Training and career development of beginning scientists Support of cutting edge basic and clinical science

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What Kinds of Research Do We Support? The AHA supports research that is broadly related to the cardiovascular area and stroke.

SCIENCE AREAS: 

SCIENCE AREAS Basic Cell and Molecular Biology Behavior Science, Epidemiology & Prevention Bioengineering & Biotechnology Brain Cardiac Biology/Regulation Cardiac Electrophysiology & Arrhythmias/Regulation Cardiorenal Cardiovascular Development Cell Transort, Physiology & Metabolism Immunology and Microbiology Liporproteins, Lipid Metabolism & Nutrition Lung, Respiration & Resuscitation

SCIENCE AREAS: 

SCIENCE AREAS Molecular Signaling Radiology & Imaging Surgery Thrombosis Vascular Biology & Blood Pressure/Regulation Vascular Wall Biology

Programs Offered by AHA National Center : 

Programs Offered by AHA National Center Scientist Development Grant January and July Application Deadline for January and July activation Fellow to Faculty Grant January and July Application Deadline for January and July activation Established Investigator Award July Application Deadline for January activation

Programs Offered by the Texas Affiliate: 

Programs Offered by the Texas Affiliate Postdoctoral Fellowship January application deadline for July activation Beginning Grant-in-Aid January application deadline for July activation Grant-in-Aid January application deadline for July activation

Postdoctoral FellowshipTo provide stipend support to help trainees initiate careers in cardiovascular and stroke research, and further research training while obtaining significant research results. (2006 Success Rate for this Program: 51 Applications, 8 funded, 16% funded): 

Postdoctoral Fellowship To provide stipend support to help trainees initiate careers in cardiovascular and stroke research, and further research training while obtaining significant research results. (2006 Success Rate for this Program: 51 Applications, 8 funded, 16% funded) Deadline: January 4, 2007 Award: $30,000 - $46,000 stipend, depending on years of training or experience, plus annual $3,000 departmental allowance.  Term: 1 or 2 years. May apply for competitive one-year award. Full-time research effort and sincere interest in pursuing a career in cardiovascular related research expected. Applicant must hold a doctoral degree and have less than 6 years of post doctoral research training and experience at award activation (July 1, 2007). Support is limited to work within non-profit institutions in Texas. Institutional supplementation permissible under certain conditions. An investigator may sponsor no more than two Affiliate Post Doctoral Fellows at any one time. Any application for a new award that would exceed this limit will not be reviewed. Each of the following criteria will be considered: The applicant The sponsor’s qualifications The environment and training program resources The specific research project

Beginning Grant-in-aidTo Promote the Independent Status of Promising Beginning Scientists by Supporting High Quality, Well-defined Research Projects in the Cardiovascular Area, Including Stroke.  (2006 Success Rate for this Program: 90 applications, 21 funded, 23% funded): 

Beginning Grant-in-aid To Promote the Independent Status of Promising Beginning Scientists by Supporting High Quality, Well-defined Research Projects in the Cardiovascular Area, Including Stroke. (2006 Success Rate for this Program: 90 applications, 21 funded, 23% funded) Deadline: January 4, 2007 Award: $65,000 per year maximum, including 10% overhead. Up to $15,000 annually for PI salary, including fringe benefits. Term: 2 years. Competitive renewal is possible for up to four years of support. Applicants must have: an MD, PhD, DO, DVM, or equivalent doctoral degree. A faculty appointment or equivalent academic or research track position, up to and including a rank of assistant professor, by the time of award activation (July 1, 2007). The applicant must meet institutional requirements for submission of an extramural, peer reviewed grant proposal. No more than 7 years of active faculty appointment prior to award activation (July 1, 2007). No more than $100,000 of all extramural grant support per year, excluding principal investigator and collaborating investigators salaries, fringe, and intramural funding Each of the following criteria will be considered: Evidence the award will promote the independent status of the applicant Scientific excellence of the proposal Qualifications of the applicant, including relevant experience, familiarity with published work in the field and productivity Adequacy of the available resources, including research facilities and institutional environment

Grant-in-aidTo Support the Most Innovative and Meritorious Research Projects FromIndependent Investigators in the Cardiovascular Area, Including Stroke.(2006 Success Rate for this Program: 78 applications, 16 funded, 21% funded): 

Grant-in-aid To Support the Most Innovative and Meritorious Research Projects From Independent Investigators in the Cardiovascular Area, Including Stroke. (2006 Success Rate for this Program: 78 applications, 16 funded, 21% funded) Deadline: January 4, 2007 Award: $65,000 per year maximum, including 10% overhead. Up to $15,000 annually for PI salary, including fringe benefits.  Term: 2 years. (One year requests are exceptional, but allowed) Continuous support of any one investigator is limited to 4 years Applicants must have: An MD, PhD, DO, DVM, or equivalent doctoral degree A faculty appointment or equivalent academic or research track position, up to and including a rank of assistant professor, by the time of award activation (July 1, 2007). The applicant must meet institutional requirements for submission of an extramural, peer reviewed grant proposal. No more than $200,000 of all extramural grant support per year, excluding principal investigator and collaborating investigators salaries, fringe, and intramural funding Grants will not be awarded to supplement or duplicate any work that is being supported by other funding agencies. The only exceptions are career development awards. The scientific merit – with emphasis on the innovative nature of the proposal – is the most important factor. Other Criteria include: The presence of new or original ideas Clear statement of research Sufficient experimental detail in the research plan Understanding of the essential methodology Adequacy of the experimental design

2006Success Rate – Texas Affiliate: 

2006 Success Rate – Texas Affiliate Awards Funded = 45 ($5,314,314) 11 cities – 18 institutions (New 2006 Awards) (RAAC allocations from May, 2006 Committee Meeting)

2006 Success Rate – National Center: 

2006 Success Rate – National Center Awards Funded = 22 ($7,500,000) 7 cities – 7 institutions (National allocations to Texas for January & July 2006)

Peer Review Structure: 

Peer Review Structure

Peer Review Study Groups2006-07: 

Peer Review Study Groups 2006-07

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Life Cycle of a Research Application Hmm… Yea!

The ProcessTexas Affiliate: 

The Process Texas Affiliate January February March April May July Application Deadline Applications assigned to Committees Committee Chairs review assignments Committee Chairs finalize assignments Reviewers input preference Paper copies are sent to reviewers Peer Review Committee meets Research Committees meet Award Notification Award activation September: online applications are available October: institutional tour to promote program

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Other AHA Scientific Products AHA Professional Membership/Scientific Council Scientific Statements/Guidelines Scientific Sessions, Conferences and Workshops AHA Scientific Journals My.Americanheart.org

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QUESTIONS? For Assistance Contact: Brent Fields VP, Research Administration 512-433-7103 – Phone