zainab and ozzy

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(there is suppose to be an animation here of the video that is attached to the essay--- it is of the woman on the newscast… it kind of adds into the little skit thing we will be doing at the beginning--- click enter)

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-Genetics Edition-

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Cardiac Rehab Center , Sunnybrook Hospital, Toronto Monday, February 28

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Skipping a Heartbeat : The NOS1AP Gene Biology 2C03-Dr. Dej T.A. – Qamber March 1 st , 2011 Zainab Rangwala , Usman Moorad & Chris Welsh Tutorial 3

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Where to Start ?

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Nitric Oxide: Role in Biological System

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Mechanism of NO synthesis

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Nitric Oxide Synthases (NOS) Name Gene(s) Location Function Neuronal NOS ( nNOS or NOS1) NOS1 nervous tissue skeletal muscle cell communication Inducible NOS (iNOS or NOS2) NOS2 immune system cardiovascular system immune defense against pathogens Endothelial NOS ( eNOS or NOS3 or cNOS ) NOS3 endothelium vasodilation Bacterial NOS ( bNOS ) Multiple various Gram(+) species defense against oxidative stress, antibiotics, immune attack

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Nitric Oxide Synthase (NOS1)

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Importance of NOS Jaffrey et al. Signal Cascade

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NOS1AP: The CAPON Protein

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SNP: Single Nucleotide Polymorphism Nitric Oxide Synthase 1 Adaptor Protein

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Individuals with SNP Jaffrey et al.

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QT Interval

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Alteration of QT interval Addition of 9.3- 12.5 milliseconds ( Lehtinen et al.)

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European vs. African American Pop’n 60% Carry Minor Allele

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Symptoms of NOS1AP mutants

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Diagnosis Rutgers University

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NOS1AP & Neuron Migration

Work Cited:

Work Cited

Any Questions?:

Any Questions?