logging in or signing up Microbial Metabolic Products 12neetika Download Post to : URL : Related Presentations : Let's Connect Share Add to Flag Embed Email Send to Blogs and Networks Add to Channel Copy embed code: Embed: Flash iPad Dynamic Copy Does not support media & animations Automatically changes to Flash or non-Flash embed WordPress Embed Customize Embed URL: Copy Thumbnail: Copy The presentation is successfully added In Your Favorites. Views: 589 Category: Entertainment License: All Rights Reserved Like it (0) Dislike it (0) Added: January 08, 2012 This Presentation is Public Favorites: 1 Presentation Description Fermentation technology Comments Posting comment... Premium member Presentation Transcript Microbial Metabolic Products: Microbial Metabolic Products Department of Pharmaceutics, AKAL COLLEGE OF PHARMACY & Tech.Edu . Submitted by: Neetika BhallaPowerPoint Presentation: Micro organisms possess tremendous capacity to produce wide range of products that have commercial value. Primary and secondary metabolites have importance for formation of biotechnologically important products.Primary Metabolites: Primary Metabolites Primary metabolism is also called TROPOPHASE . Characterized by balanced growth of micro organisms. Essential for existence and reproduction of cells. During period of tropophase exponential growth of micro organisms occur. For industrial over production the regulatory mechanisms are suitably manipulatedTypes Of Primary Metabolites: Types Of Primary Metabolites Primary Essential Metabolites- ( vitamins , amino acids) Primary Metabolic End Products –( Ethanol, Acetone)Limitations In Growth: Limitations In Growth Due to limited supply of any nutrient, growth rate of micro organisms slows down. But metabolism does not stop ; it continues as long as the cell lives, but formation of products differ.Over Production Of Primary Metabolites: Over Production Of Primary Metabolites By using auxotropic mutants - It causes blockage in one of steps in biosynthetic pathway concerned with formation of primary metabolite. Anti- metabolite Resistance in Mutants – Exhibit defective metabolic regulation which over produce primary metabolites.Secondary Metabolites: Secondary Metabolites Formation occurs in idiophase . Not required by microbes. Industrially useful. Examples- Antibiotics , Steroids, Alkaloids.Characteristics: Characteristics Specifically produced by microbes. Not essential for growth. Environmental factors affect production. In some cases, produced as group of compounds. Regulation is complex.Functions Of Secondary Metabolites: Functions Of Secondary Metabolites May perform functions beneficial for survival of cells. They have no function. Their production alone is important for cells.Over Production Of Secondary Metabolites: Over Production Of Secondary Metabolites Regulatory Mechanisms Are :- Induction:- Tryptophan regulates ergot alkaloid biosynthesis. End Product Regulation:- Isolate mutants that are sensitive to end product inhibition. Catabolic Regulation:- Mechanism not understood. Catabolic repression achieved using carbon or nitrogen source.PowerPoint Presentation: Phosphate Regulation Increasing phosphate concentration is associated with increased secondary metabolite production . Example- Antibiotics. Very high concentration of Pi is inhibitory. Mechanism is not clear.PowerPoint Presentation: Auto regulation:- In actinomycetes , self regulation for production of secondary metabolites occur. Factor-A is believed to be involved in auto regulation for production of Streptomycin by Streptomyces griseus .PowerPoint Presentation: Secondary metabolites Source Applications 1.Atropine Atropa belladona Anticholinergic agent 2.Quinine Cinchona Antimalarial 3.Digoxin Digitalis Cardiac tonic 4.Vincristine Catharanthus roseus Anticancer You do not have the permission to view this presentation. In order to view it, please contact the author of the presentation.